Adipose Fat Quality vs Quantity: Relationships with Children''s Serum Lipid Levels

BACKGROUND: There is a controversy as to the relative importance of obesity vs quality of dietary fat in the prediction of serum lipoproteins in children. A reason for this is an apparent lack of studies implementing biomarkers of long-term dietary fat intake among children. The objective of the present study was to assess the relative contribution of degree of obesity, fat centrality, and quality of adipose tissue fat in the prediction of serum lipids in 12-year-old children. METHODS: Pupils came from 40 schools randomly selected among 541 primary schools in three different provinces of the island of Crete. One thousand forty-six pupils were examined at age 6. At age 9, a representative sample from the original cohort (n = 579) was randomly selected for reevaluation. At the age of 12, a representative sample of 831 pupils was reexamined. At ages 6, 9, and 12, serum lipid measures were obtained from 941, 458, and 791 children, respectively. At age 12, data were obtained on pupils' anthropometry, serum lipids, dietary intake, physical fitness, and physical activity. Adipose tissue fatty acid data were obtained from a subsample of 194 children at age 12. RESULTS: Regression analyses indicated that children's serum triglycerides related positively to body mass index and waist-hip ratio (WHR). Serum HDL-C related negatively to WHR and positively to endurance run test, an index of physical fitness. Dietary fatty acids, assessed by a single administration of 3-day weighed-food records, did not relate to serum lipids. However, serum HDL-C related negatively to sum of adipose polyunsaturated fatty acids, a measure of long-term polyunsaturated fat intake. CONCLUSIONS: It appears that obesity and fat centrality are stronger predictors of children's serum lipids than the quality of long-term dietary fat intake or adipose tissue fatty acid composition. It is possible that this finding may relate to the particular subcutaneous depot studied. It is suggested that future studies study abdominal rather than buttock adipose tissue fatty acid composition in relation to children's serum lipid levels.     

Appropriate responses by elders to oral symptoms: dentists' recommendations

This paper reports the results of a study of dentists' recommendations regarding the appropriate health action of elders in response to certain oral common symp toms and problems. Previous studies have found that elders most commonly respond to oral symptoms by using nonprofessional means. This study found that, without exception, the recommendation to consult a dentist was the primary mode of response favored by dentists, even in response to symptoms and problems that are most often trivial and rarely indicative of serious health problems. The results of this pilot study suggest that the need exists for dentists to reach a more realistic consensus regarding alternatives to professional consultation in response to some symptoms and problems.     

鳞状细胞癌患者血SOD活性测定

利用一种微量末梢血测定超氧化物歧化酶(SOD)活性的简易方法——邻苯三酚自氧化法,测定了12例鳞状细胞癌患者及20例年龄相近健康人血中的C_u—Z_n—SOD活性。健康人血SOD活性平均为1341.76±78.74u/gHb,鳞癌患者血SOD活性平均为1004.34±80.96u/gHb,后者SOD活性明显低于前者,两组均数间差异有非常显著的统计学意义(P<0.01)。鳞癌患者体内SOD活性降低与鳞癌的发生、发展、转移以及治疗和预后的关系值得进一步研究。     

The clinicopathological significance of p21 and p53 expression in esophageal squamous cell carcinoma: an analysis of 153 patients

OBJECTIVE: The p21 gene is thought to play a central role in tumor suppression. The aim of this study was to examine the clinicopathological role of p21 and p53 in esophageal squamous cell carcinomas. METHODS: The expression of p21 and p53 proteins in 153 Chinese patients (131 men, 22 women) with resected esophageal squamous cell carcinomas was investigated by the immunohistochemical method. Correlation between p21 and p53 expression and clinicopathological features was examined. RESULTS: The expression of p21 and p53 was detected in 70% and 64% of the tumors, respectively. The staining of p21 and p53 was also found in squamous carcinoma in situ, dysplasia, and nontumor epithelium. p21 expression was often weak in the suprabasal cells and found in better differentiated tumors. There was no significant correlation between the expression of p21 and the abnormal accumulation of p53. The prognosis of the patients depended on the size, stage, and p21 expression of the lesion. In stage III lesions with tumor diameter < or = 7.5 cm (n = 93), patients with loss of p21 expression had better survival. The survival rates of patients were worse if they had expression of both p21 and p53. CONCLUSIONS: Thus, p21 and p53 had prognostic value for esophageal squamous cell carcinomas. Loss of p21 expression was shown without p53 alternations, indicating that other mechanisms are also involved in turning off the gene. The pattern of p21 and p53 expression predicts an aggressive clinical course of esophageal squamous cell carcinomas.     

Dislocation of an upper third molar by an ossifying fibroma – Case report

BACKGROUND: The occurrence of ossifying fibromas (OFs) in childhood and adolescence has been described in the literature, along with different courses of the disease due to different growth rates. CASE REPORT: In the case of the 15-year-old female patient presented here, an OF resulted in displacement of a maxillary third molar far into the maxillary sinus. It is assumed that the tumour originated coronal to the affected tooth 18. Radiographs document an initial rapid growth of this tumour over a period of 2 years, while its growth almost completely ceased in the next 2 years immediately prior to diagnosis and surgical treatment. The operation was complicated by unexpected profuse bleeding from the tumour tissue. CONCLUSION: The peculiarity of the OF in the case presented here is its similarity, in terms of clinical and radiological appearances, with a follicular cyst, its unusual place of origin that resulted in the migration of the tooth 18 into the maxillary sinus, its different growth dynamics, and the pronounced haemorrhage encountered as the tumour was surgically removed.     

心肌显像剂~(99m)Tc-TBI的Ⅰ期临床试验

在放射性新药~(99m)T_c-TBI Ⅰ期临床试验中,对10名正常受试者进行了观察。结果表明,该药作为心肌灌注显像剂,制备力方法简便,安全、有效。平面显像由于肝影干扰,影响对心肌下、后壁的观察;断层显像基本上能克服此缺点,得到满意的结果。     

~(99m)Tc-HMPAO SPECT rCBF断层影像诊断标准探讨

应用SPECT及~(99m)Tc-HMPAO对健康志愿者和常见神经疾患病人进行了断层显像,利用ROC分析法,制定了适合于图像分析的诊断标准,并对该标准进行了检验。     

α-(取代苯丙酮酰氨基)-β-取代苯基丙烯酸乙酯化合物的360兆核磁共振氢谱和碳谱

本文由360兆核磁共振仪测定的PMR和CMR谱,结合元素分析、IR及MS等数据,确定了三个未知化学结构的化合物为α-(取代苯丙酮酰氨基)-β-取代苯基丙烯酸乙酯,并归属了全部CMR谱线。由80兆PMR则无法判明。