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131.
The purpose of this investigation was to establish a standardized animal model to predict the photoallergenic potential of new chemical compounds. In a first series of experiments the main factors influencing the induction of photoallergenicity were evaluated (induction concentration, pH of the test solution, pretreatment of the irradiation site with sodium lauryl sulphate, additional use of adjuvant injections and routes of administration). Osram Ultravitalux lamps were utilized for these studies.
In a second series of experiments a Xenon 6000 W radiation source was used. Positive results were obtained with well known photosensitizers, as, for instance, the halogenated salicylanilides, as well as with so-called weak photoallergens (e.g. bithionol, sulphanilamide) by stimulating the animals' immune system with Freund's complete adjuvant.
The photoallergenic compounds were at the same time tested for their contact allergenic potential in the optimization test.
A standard procedure for the predictive photoallergenicity assay in guinea-pigs is proposed. 相似文献
In a second series of experiments a Xenon 6000 W radiation source was used. Positive results were obtained with well known photosensitizers, as, for instance, the halogenated salicylanilides, as well as with so-called weak photoallergens (e.g. bithionol, sulphanilamide) by stimulating the animals' immune system with Freund's complete adjuvant.
The photoallergenic compounds were at the same time tested for their contact allergenic potential in the optimization test.
A standard procedure for the predictive photoallergenicity assay in guinea-pigs is proposed. 相似文献
132.
Miss Jane Cole was 26 years old when admitted to Chestnut Lodge with a diagnosis of schizophrenia in 1949. She remained an inpatient and day patient for 18 years, and engaged in treatments that were primarily psychotherapeutically oriented, with three different therapists. She ultimately recovered sufficiently to live on her own while remaining in private treatment with her last Chestnut Lodge therapist. Her extended psychotherapeutic encounters at this institution are richly documented, with about 400 pages of transcribed annual treatment case conferences, allowing us to reconstruct her course in some detail. We offer her narrative as uniquely instructive about the utility of different psychotherapeutic models and styles in the treatment of people with long-term, severe, psychotic disorders. 相似文献
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The chief resident in psychiatry 总被引:1,自引:0,他引:1
136.
The serum levels of soluble intercellular adhesion molecule 1 (ICAM-1) were significantly elevated (P < .001) in patients with chronic B- lymphocytic leukemia (B-CLL, n = 113) compared with healthy controls (n = 31). sICAM-1 levels in B-CLL were positively correlated to the tumor mass as reflected by the modified Rai and the Binet staging systems, lymphocyte counts, and isolated spleno/hepatomegaly. During disease progression or regression on cytoreductive therapy, the circulating sICAM-1 levels changed accordingly. sICAM-1 was also correlated to a kinetic parameter such as the lymphocyte doubling time. Furthermore, the serum sICAM-1 levels were inversely correlated to hemoglobin levels in patients with early clinical stage, and this may turn out to be of prognostic value. sICAM-1 was compared with other serum markers said to reflect disease activity in B-CLL, ie, soluble CD23, thymidine kinase, lactate dehydrogenase (LDH), and beta 2-microglobulin. sICAM-1 was equally well or better correlated to clinical stage and lymphocyte doubling time. In univariate regression analysis, all serum markers but LDH correlated with survival, and in multivariate analysis, sICAM-1 was the only marker approaching significance for additional prognostic information when included after clinical stage and lymphocyte doubling time. Based on the present observations, it appears that prospective studies repeatedly monitoring serum sICAM-1 in B-CLL are justified. 相似文献
137.
Gastric enteric neurones that respond to luminal injury 总被引:1,自引:0,他引:1
138.
Antibody-dependent enhancement of HIV-1 infection in human term syncytiotrophoblast cells cultured in vitro
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F. D. T
TH P. MOSBORG-PETERSEN J. KISS G. ABOAGYE-MATHIESEN M. ZDRAVKOVIC H. HAGER J. ARANYOSI L. LAMP P. EBBESEN 《Clinical and experimental immunology》1994,96(3):389-394
We examined if Fc receptor-mediated antibody-dependent enhancement (FcR-ADE) or complement-mediated antibody-dependent enhancement (C′-ADE) of virus infection can contribute to increasing replication of HIV-1 in human syncytiotrophoblast (ST) cells. Here we report that both FcR-ADE and C′-ADE may result in enhanced virus release from HIV-1-infected ST cells. We show that FcR-ADF of HIV-1 infection in ST cells is mediated by FcRIII and other FcR(s) belonging to undetermined Fc classes and does not require CD4 receptors, whereas C'-ADE uses both CD4 and CR2-like receptors. FcR-ADE: seems to be more efficient in enhancing HIV-I replication than C′-ADE. While FcR-ADE leads to increased internalization of HIV-1. C′-ADE does not result in enhanced endocytosis of the virus. In addition, antibodies mediating FcR-ADE arc reactive with the gp120 viral envelope antigen, whereas antibodies involved in C′-ADE react with the viral transmembrane glycoprotein gp41. Data suggest that both FcR-ADH and C′-ADE may contribute lo the spread of HIV-1 from mother to the fetus. 相似文献
139.
T H McGlashan 《Archives of general psychiatry》1984,41(2):141-144
Four diagnostic systems for schizophrenia--New Haven, Feighner et al, Research Diagnostic Criteria, and DSM-III--were tested for reliability, comprehensiveness, concordance with established clinical use, specificity, and predictive validity. The sample consisted of 400 patients admitted to Chestnut Lodge, Rockville, Md, 330 of whom received long-term follow-up assessment by interview an average of 15 years after discharge. Diagnostic system criteria were applied retrospectively to abstracted medical records. Findings replicated recent studies on schizophrenia diagnosis and extended the generalizability of current nosologic systems to chronically ill patients. Results also indirectly supported the validity of applying these systems to medical records. This study demonstrated advantages and disadvantages of each system. 相似文献
140.