全文获取类型
收费全文 | 2923篇 |
免费 | 302篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 16篇 |
儿科学 | 101篇 |
妇产科学 | 44篇 |
基础医学 | 426篇 |
口腔科学 | 44篇 |
临床医学 | 421篇 |
内科学 | 480篇 |
皮肤病学 | 54篇 |
神经病学 | 198篇 |
特种医学 | 105篇 |
外科学 | 385篇 |
综合类 | 71篇 |
一般理论 | 3篇 |
预防医学 | 380篇 |
眼科学 | 11篇 |
药学 | 227篇 |
肿瘤学 | 266篇 |
出版年
2021年 | 51篇 |
2020年 | 42篇 |
2019年 | 40篇 |
2018年 | 39篇 |
2017年 | 45篇 |
2016年 | 44篇 |
2015年 | 42篇 |
2014年 | 71篇 |
2013年 | 95篇 |
2012年 | 128篇 |
2011年 | 145篇 |
2010年 | 82篇 |
2009年 | 66篇 |
2008年 | 145篇 |
2007年 | 133篇 |
2006年 | 136篇 |
2005年 | 136篇 |
2004年 | 109篇 |
2003年 | 112篇 |
2002年 | 100篇 |
2001年 | 99篇 |
2000年 | 104篇 |
1999年 | 101篇 |
1998年 | 52篇 |
1997年 | 35篇 |
1996年 | 32篇 |
1995年 | 30篇 |
1994年 | 26篇 |
1993年 | 30篇 |
1992年 | 95篇 |
1991年 | 76篇 |
1990年 | 74篇 |
1989年 | 85篇 |
1988年 | 61篇 |
1987年 | 54篇 |
1986年 | 38篇 |
1985年 | 43篇 |
1984年 | 31篇 |
1983年 | 28篇 |
1982年 | 24篇 |
1981年 | 19篇 |
1980年 | 18篇 |
1979年 | 39篇 |
1977年 | 24篇 |
1976年 | 18篇 |
1975年 | 24篇 |
1974年 | 27篇 |
1973年 | 24篇 |
1970年 | 17篇 |
1967年 | 18篇 |
排序方式: 共有3232条查询结果,搜索用时 15 毫秒
81.
Sheng‐Wei Chang Mona Mislankar Chaitali Misra Nianyuan Huang Daniel G. DaJusta Steven M. Harrison Kim L. McBride Linda A. Baker Vidu Garg 《Human mutation》2013,34(9):1226-1230
The etiology for the majority of congenital heart defects (CHD) is unknown. We identified a patient with unbalanced atrioventricular septal defect (AVSD) and hypoplastic left ventricle who harbored an ~0.3 Mb monoallelic deletion on chromosome 3p14.1. The deletion encompassed the first four exons of FOXP1, a gene critical for normal heart development that represses cardiomyocyte proliferation and expression of Nkx2.5. To determine whether FOXP1 mutations are found in patients with CHD, we sequenced FOXP1 in 82 patients with AVSD or hypoplastic left heart syndrome. We discovered two patients who harbored a heterozygous c.1702C>T variant in FOXP1 that predicted a potentially deleterious substitution of a highly conserved proline (p.Pro568Ser). This variant was not found in 287 controls but is present in dbSNP at a 0.2% frequency. The orthologous murine Foxp1 p.Pro596Ser mutant protein displayed deficits in luciferase reporter assays and resulted in increased proliferation and Nkx2.5 expression in cardiomyoblasts. Our data suggest that haploinsufficiency of FOXP1 is associated with human CHD. 相似文献
82.
J. Garau H. Ostermann J. Medina M. Ávila K. McBride F. Blasi 《Clinical microbiology and infection》2013,19(9):E377-E385
Complicated skin and soft tissue infections (cSSTI) are common and frequently require treatment in hospital. Comprehensive current data on management practices in patients hospitalized with cSSTI are limited. REACH was a retrospective, observational cohort study designed to provide data on current clinical management of moderate to severe cSSTI in European hospitals. Data were collected via an electronic case report form from 129 sites in ten European countries. The study population comprised patients ≥18 years, hospitalized between March 2010 and February 2011 with cSSTI who received intravenous antibiotic treatment. Presented here is an analysis of the disease characteristics, treatment patterns during hospitalization and clinical outcomes identified by the study. The total population included 1995 patients (mean age 60.6 years; 57.7% male). Initial antibiotic treatment modification was reported in 39.6% (n = 791) of patients; it was more common in patients with co-morbidities (42.6%), those requiring surgical intervention (43.4%), those with more severe infections such as bacteraemia (51.6%) or with fascia affected (49.0%), those admitted to the intensive care unit (56.2%) and those with lesions > 50 cm2 (44.3%). A switch to narrower-spectrum antibiotic treatment (streamlining) occurred in 5.6% of patients. Mean length of hospital stay was 18.5 days (±19.9; median 12.0) and the total mortality rate was 3.4%. The data collected in REACH give a comprehensive and current view of real-life clinical management of cSSTI in European hospitals and provide evidence of a high rate of initial antibiotic treatment modification. 相似文献
83.
Juxtaposition of the T-cell receptor alpha-chain locus (14q11) and a region (14q32) of potential importance in leukemogenesis by a 14;14 translocation in a patient with T-cell chronic lymphocytic leukemia and ataxia-telangiectasia. 总被引:2,自引:2,他引:2 下载免费PDF全文
M P Davey V Bertness K Nakahara J P Johnson O W McBride T A Waldmann I R Kirsch 《Proceedings of the National Academy of Sciences of the United States of America》1988,85(23):9287-9291
We describe a t(14;14)(q11;q32) translocation in a patient with T-cell chronic lymphocytic leukemia and ataxia-telangiectasia (AT). By using a battery of joining (J)-segment probes from the T-cell receptor (TCR) alpha-chain locus TCRA, three distinct J alpha rearrangements were observed. One rearrangement reflected a normal TCRA variable (V) region V alpha-to-J alpha recombination. The second rearrangement was caused by the translocation even itself, which joined a DNA segment from 14q32 centromeric to the immunoglobulin heavy chain locus (IGH) and a J alpha gene located approximately 75 kilobases (kb) 5' of the TCRA constant region gene (C alpha). A third rearrangement involved a 17-kb internal deletion 3' to the translocation, a rearrangement within the J alpha locus that has been observed once before in a patient with AT. Analysis of these three rearrangements underscores the increase in aberrant locus-specific recombination in lymphocytes from patients with AT. Furthermore, these studies support the view that a growth-effecting gene is present in the 14q32 region that participates in the leukemogenic process. 相似文献
84.
Antiarrhythmic drug therapy and cardiac mortality in atrial fibrillation. The Stroke Prevention in Atrial Fibrillation Investigators. 总被引:5,自引:0,他引:5
G C Flaker J L Blackshear R McBride R A Kronmal J L Halperin R G Hart 《Journal of the American College of Cardiology》1992,20(3):527-532
BACKGROUND AND OBJECTIVES. The relation between cardiac mortality and antiarrhythmic drug administration has not been fully determined. This relation was analyzed in 1,330 patients enrolled in the Stroke Prevention in Atrial Fibrillation Study, a randomized clinical trial comparing warfarin, aspirin and placebo for the prevention of ischemic stroke or systemic embolism in patients with nonvalvular atrial fibrillation. METHODS. Patients who received antiarrhythmic drug therapy for atrial fibrillation in this study were compared with patients not receiving antiarrhythmic agents. The relative risk of cardiac mortality, including arrhythmic death, in patients receiving antiarrhythmic drug therapy was determined and adjusted for other cardiac risk factors. RESULTS. In patients receiving antiarrhythmic drug therapy, cardiac mortality was increased 2.5-fold (p = 0.006, 95% confidence interval [CI] 1.3 to 4.9) and arrhythmic death was increased 2.6-fold (p = 0.02, 95% CI 1.2 to 5.6). Among patients with a history of congestive heart failure, those given antiarrhythmic medications had a relative risk of cardiac death of 4.7 (p less than 0.001, 95% CI 1.9 to 11.6) compared with that of patients not so treated; the relative risk of arrhythmic death in the treated group was 3.7 (p = 0.01, 95% CI 1.3 to 10.4). Patients without a history of congestive heart failure had no increased risk of cardiac mortality (relative risk 0.70, 95% CI 0.2 to 3.1) during antiarrhythmic drug therapy. After exclusion of 23 patients with documented ventricular arrhythmias and adjustment for other variables predictive of cardiac death, patients receiving antiarrhythmic drugs were not at increased risk of cardiac death or arrhythmic death. However, in patients with a history of heart failure who received antiarrhythmic drug therapy, the relative risk of cardiac death was 3.3 (p = 0.05, 95% CI 0.99 to 11.1) and that of arrhythmic death was 5.8 (p = 0.009, 95% CI 1.5 to 21.7) compared with the risk in patients not taking antiarrhythmic medications. CONCLUSIONS. Although antiarrhythmic drug therapy was not randomly determined in this trial, the data suggest that in patients with atrial fibrillation and a history of congestive heart failure, the risk of such therapy may outweigh the potential benefit of maintaining sinus rhythm. 相似文献
85.
86.
87.
88.
89.
Desta Ayode Colleen M. McBride Hendrik de Heer Emi Watanabe Tsega Gebreyesus Getnet Tadele Abebayehu Tora Gail Davey 《The American journal of tropical medicine and hygiene》2012,87(4):623-630
Little is known about how beliefs about heredity as a cause of health conditions might influence preventive and interpersonal behaviors among those individuals with low genetic and health literacy. We explored causal beliefs about podoconiosis, a neglected tropical disease (NTD) endemic in Ethiopia. Podoconiosis clusters in families but can be prevented if individuals at genetically high risk wear shoes consistently. Adults (N = 242) from four rural Ethiopian communities participated in qualitative assessments of beliefs about the causes of podoconiosis. Heredity was commonly mentioned, with heredity being perceived as (1) the sole cause of podoconiosis, (2) not a causal factor, or (3) one of multiple causes. These beliefs influenced the perceived controllability of podoconiosis and in turn, whether individuals endorsed preventive and interpersonal stigmatizing behaviors. Culturally informed education programs that increase the perceived controllability of stigmatized hereditary health conditions like podoconiosis have promise for increasing preventive behaviors and reducing interpersonal stigma. 相似文献
90.
Richard O. Temple Angela M. McBride Michael David Horner Robin M. Taylor 《The Clinical neuropsychologist》2013,27(3):402-409
This study examined the relationship between performance on the Portland Digit Recognition Test (PDRT) and the MMPI-2 in a group of veterans who were suspected of having motivation to exaggerate cognitive and/or psychiatric symptoms. Number correct on “easy” trials on the PDRT correlated inversely with MMPI-2 measures of psychopathology, whereas number correct on “hard” trials positively correlated with the same scales. Some individuals performed poorly across both types of PDRT trials and had significant MMPI-2 elevations, whereas others performed poorly only on “hard” PDRT trials and had less extreme MMPI-2 elevations. This study reinforces the need to assess the validity of both cognitive and psychiatric symptom complaints. 相似文献