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991.
Guido Torzilli Matteo Donadon Jacques Belghiti Norihiro Kokudo Tadatoshi Takayama Alessandro Ferrero Gennaro Nuzzo Jean-Nicolas Vauthey Michael A. Choti Eduardo De Santibanes Masatoshi Makuuchi 《Journal of gastrointestinal surgery》2016,20(6):1154-1162
Introductions
Different staging systems have been devised for patients undergoing resection for hepatocellular carcinoma (HCC) with disparate results. The aim of this study was to create a new nomogram to predict individual survival after hepatectomy for HCC.Methods
Based on the “Hepatocellular Carcinoma: Eastern & Western Experiences Network,” data from 2046 patients who underwent HCC resections at ten centers were reviewed. Patient survival was analyzed with Cox-regression analysis to construct a unique nomogram and contour plots to predict survival.Results
The nomograms built on the multivariate analyses, which showed that the independent predictors were tumor size, tumor number, vascular invasion, cirrhosis, preoperative bilirubin value, and esophageal varices, showed good calibration and discriminatory abilities with C-index value of 0.62 (95 % CI, 0.59–0.69) and 0.61 (95 % CI, 0.56–0.64) for overall and disease-free survival, respectively. The 5-year survival contour plots showed that the presence of vascular invasion was associated with decreased survival, regardless of the tumor number or size. Cirrhosis and varices were equally associated with decreased survival, according to the tumor number or size.Conclusions
These nomograms accurately predict individual prognosis after HCC resection and support an expansion of the selection criteria for resection. They offer useful guidance to clinicians for individual survival prediction.992.
Masahiro Okuno Shigeru Sakaguchi Masayoshi Nagayama Takafumi Yamashita Shohei Sakazaki Kazuhiko Yoshikawa Eiji Taruya Akira Fukamizu Kaoru Umeyama 《Surgery today》1984,14(3):244-247
This is a report of a 63-year-old Japanese woman with a nonfunctioning islet cell carcinoma of the pancreas presenting bleeding
gastric varices and splenomegaly. These manifestations are extremely rare in patients with nonfunctioning islet cell tumor.
The tumor originated in the tail of the pancreas and grew mainly within the spleen. The gastric varices due to increased blood
flow to the tumor and arteriovenous fistuals within the tumor were confirmed by angiography and operation. The tumor was resected
and she is in a good health for 14-months after the operation. 相似文献
993.
Hiroki Ochi Yasushi Hara Masahiro Tagawa Kenichi Shinomiya Yoshinari Asou 《Journal of orthopaedic research》2010,28(5):657-663
LPS (lipopolysaccharide), a major constituent of Gram‐negative bacteria, regulates proliferation and differentiation of osteoclasts directly or indirectly. This study sought to investigate the functions of the RANK/RANKL pathway in LPS‐induced bone loss in vivo. Wild‐type mice or TNFR1?/? mice were injected LPS with or without osteoprotegerin (OPG) and analyzed histologically. Bone volume was reduced by LPS injection in all groups, and OPG administration prevented the LPS‐induced bone loss regardless of genotypes. LPS‐induced enhancement of osteoclastogenesis in wild‐type mice was blocked by OPG administration. LPS or OPG did not affect osteoclastogenesis in TNFR1?/? mice. Interestingly, osteoblast surface was remarkably reduced in LPS‐treated TNFR1?/? mice as a result of enhanced osteoblast apoptosis. TRAIL, induced by TNF‐α in BMC, triggered apoptosis of primary osteoblast only when TNFR1 signal was ablated in vitro. In conclusion, RANK signaling plays a prominent role in osteoclastogenesis downstream of LPS. Furthermore, TNFR1 regulates bone metabolism through not only the regulation of osteoclast differentiation but also osteoblast survival. © 2009 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 28:657–663, 2010 相似文献
994.
Takeshi Aoyama Susumu Kunisawa Kiyohide Fushimi Teiji Sawa Yuichi Imanaka 《Journal of cardiothoracic surgery》2018,13(1):129
Background
In recent years, surgical outcomes have improved, and positive reports on surgery for type A aortic dissection (AAD) in the elderly are increasing. However, the difference between surgical and conservative treatments in the elderly remains unclear. Therefore, we conducted this study to determine whether surgery should be performed for Stanford (AAD) in elderly patients.Methods
Data of patients aged 80?years or older who were hospitalized for AAD from April 2014 to March 2016 were extracted from the Japanese national inpatient database. Outcome measures were all-cause in-hospital death, stroke, acute kidney injury and tracheotomy, and composite adverse events (consisting of all-cause in-hospital death, stroke, acute kidney injury, and tracheotomy), and we compared them between surgical and conservative treatments using propensity score matching.Results
The study cohort included 3258 patients, with 845 matched pairs (1690 patients) in the propensity score matching. All-cause in-hospital death was significantly lower in the surgical treatment group than in the conservative treatment group before and after matching (15.6% vs. 51.1%, p?<?0.001; 16.7% vs. 31.6%, p?<?0.001, respectively); however, there was no significant difference in composite adverse events after matching (36.0%, conservative vs. 37.2%, surgical; p?=?0.65), and adjusted odds ratio was 1.06 and 95% confidence interval was 0.86–1.29 (p?=?0.61) with reference to conservative treatment.Conclusions
All-cause in-hospital death among elderly patients with AAD was significantly lower in patients treated surgically than in those undergoing conservative treatment. However, there was no significant difference between the two groups in the event-free survival, which is important for the elderly. These findings may be used in the consideration of treatment course for elderly patients with AAD.995.
Onodera M Kawakami H Kuwatani M Kudo T Haba S Abe Y Kawahata S Eto K Nasu Y Tanaka E Hirano S Asaka M 《Surgical endoscopy》2012,26(6):1710-1717
Background
Endoscopic ultrasound (EUS)-guided drainage is widely used to manage pancreatic pseudocysts. Several studies have reported the use of EUS-guided drainage for pancreatic fistula and stasis of pancreatic juice caused by stricture of the pancreatic duct after pancreatic resection.Methods
At the authors’ hospital, 262 patients underwent surgery involving pancreatic resection from April 2005 to March 2010. In 90 of these patients (34%), a grade B or C postoperative pancreatic fistula developed that required additional treatment. The authors performed EUS-guided transmural drainage (EUS-TD) for six patients (2.1%) with a pancreatic fistula or dilation of the main pancreatic duct visible by EUS. Percutaneous drainage was provided for 18 patients (6.8%). The success rates for EUS-TD and percutaneous drainage were compared in a retrospective analysis.Results
In all six cases, EUS-TD was performed successfully without complications. Five of the six patients were successfully treated with only one trial of EUS-TD. The final technical success rate was 100% for both EUS-TD and percutaneous drainage. Both the short- and long-term clinical success rates for EUS-TD were 100% and those for percutaneous drainage were 61.1 and 83%, respectively. The differences in these rates were not significant (short-term success, P?=?0.091 vs. long-term success, P?=?0.403). However, the time to clinical success was significantly shorter with EUS-TD (5.8?days) than with percutaneous drainage (30.4?days; P?=?0.0013) in the current series.Conclusions
The EUS-TD approach appears to be a safe and technically feasible alternative to percutaneous drainage and may be considered as first-line therapy for pancreatic fistulas visible by EUS. 相似文献996.
Background Appropriate management of cystic lesions of the pancreas is controversial. Major pancreatectomies (pancreaticoduodenectomy
or distal pancreatectomy with splenectomy) are the commonly used procedures, even though most cystic lesions are noninvasive
neoplasms. We tested the adequacy of limited pancreatectomies in the treatment of pancreatic cystic lesions.
Methods Data from 109 patients who underwent surgical resection of a pancreatic cystic lesion at National Taiwan University Hospital
from 2001 to 2007 were retrospectively reviewed. Major pancreatomies (n = 79) constituted pancreaticoduodenectomy and total/distal
pancreatectomies, while other resection procedures (n = 30) represented limited pancreatectomies. Clinicopathologic features
were compared between the major and limited groups.
Results There were no statistically significant differences in sex, age, presence of symptoms, cyst diameter, minor or major treatment
complications, or pancreatic leakage between the two groups. Cystic lesions located in the neck/body/tail rather than in the
head/uncinate process were significantly more often treated with limited pancreatectomy (P = .02). Both groups had similar pathologic distribution of cystic lesions, with the exception of nine invasive neoplasms.
The latter were treated with major pancreatectomy. No recurrence was noted in 100 patients with noninvasive cystic neoplasms
after major or limited pancreatectomy.
Conclusions Noninvasive pancreatic cystic neoplasms can be safely and effectively treated by limited pancreatectomy. 相似文献
997.
Ryu KW Kim YW Lee JH Nam BH Kook MC Choi IJ Bae JM 《Annals of surgical oncology》2008,15(6):1625-1631
Background Information on surgical complications of laparoscopy-assisted distal gastrectomy (LADG) and their risk factors is limited
in the literature despite increasing popularity of this procedure. This study was performed to identify the surgical complications
and their associated risk factors of LADG in early gastric cancer.
Methods LADG was performed in 347 gastric cancer patients from January 2002 to December 2006 at the Korean National Cancer Center
by four surgeons with ample experience of open gastric surgery before LADG. LADG indications for cases of gastric cancer at
our institution are preoperatively diagnosed cT1N0 or cT1N1, except in cases with an absolute indication for endoscopic resection.
Lymph node dissection of more than D1 + β was performed in all patients. Intraoperative and postoperative complications were
reviewed and their risk factors were retrospectively analyzed by prospective database information.
Results Forty complications occurred in 34 patients (9.8%), but there was no mortality. Intraoperative complications occurred in nine
patients (2.6%), and open conversion was performed in eight (2.3%) of these patients. Early and late postoperative complications
occurred in 21 (6.1%) and 10 (2.9%) patients, respectively. The most serious complication was vascular injury resulting in
bleeding or organ ischemia, which occurred in seven patients. Degree of lymph node dissection and surgical inexperience were
found to be risk factors of surgical complication (P = .023, odds ratio 2.832, 95% confidence interval 1.155–6.946 vs. P = .028, odds ratio 2.975, 95% confidence interval 1.127–7.854).
Conclusions Lymph node dissection during LADG should be performed cautiously to prevent surgical complications like vascular injuries,
especially during the surgeon’s early learning period. 相似文献
998.
Takagawa R Fujii S Ohta M Nagano Y Kunisaki C Yamagishi S Osada S Ichikawa Y Shimada H 《Annals of surgical oncology》2008,15(12):3433-3439
Background We evaluated the prognostic value of the preoperative serum carcinoembryonic antigen (CEA) level in patients with colorectal
cancer (CRC).
Patients and Methods The study group comprised 638 patients. The optimal cutoff value for the preoperative serum CEA level was determined. Predictive
factors of recurrence were evaluated using multivariate analyses. The relapse-free time was investigated according to the
CEA level.
Results All patients underwent potentially curative resection for CRC without distant metastasis, classified as stage I, II, or III.
The optimal cutoff value for preoperative serum CEA level was 10 ng/ml. Elevated preoperative serum CEA level was observed
in 92 patients. Multivariate analysis identified tumor–node–metastasis (TNM) stage and preoperative serum CEA level as independent
predictive factors of recurrence. The relapse-free survival between CEA levels >10 ng/ml and <10 ng/ml significantly differed
in patients with stage II and III. However, there was no significant difference in relapse-free survival between CEA levels
>10 ng/ml and <10 ng/ml in patients with stage I.
Conclusion Preoperative serum CEA is a reliable predictive factor of recurrence after curative surgery in CRC patients and a useful indicator
of the optimal treatment after resection, particularly for cases classified as stage II or stage III. 相似文献
999.
Daltro C Gregorio PB Alves E Abreu M Bomfim D Chicourel MH Araújo L Cotrim HP 《Obesity surgery》2007,17(6):809-814
Background Obesity is the most important risk factor for obstructive sleep apnea. It is estimated that 70% of sleep apnea patients are
obese. In the morbidly obese, the prevalence may reach 80% in men and 50% in women. The aim of this study was to determine
the prevalence and severity of sleep apnea in a group of morbidly obese patients, leading to bariatric surgery.
Methods In a cross-sectional study developed in Bahia, northeastern Brazil. 108 patients (78 women and 30 men) from the Obesity Treatment
and Surgery Center - “Núcleo de Tratamento e Cirurgia da Obesidade” underwent standard polysomnography. Patients with an apnea-hypopnea
index (AHI) ≥ 5 events/hour were considered apneic.
Results Mean ± SD for age and BMI were 37.1 ± 10.2 years and 45.2 ± 5.4 kg/m2, respectively. The calculated AHI ranged widely from
2.5 to 128.9 events/hour. Sleep apnea was detected in 93.6% of the sample, wherein 35.2% had mild, 30.6% moderate and 27.8%
severe apnea. Oxyhemoglobin desaturation was directly related to the AHI and was more severe in men.
Conclusion There was a high frequency of sleep apnea in this group of morbidly obese patients, for whom it was very important to request
polysomnography, thus enabling therapeutic management and prognostication. 相似文献
1000.
Inflammatory Pseudotumor of the Spleen: Report of a Case 总被引:1,自引:0,他引:1
We report the case of an inflammatory pseudotumor of the spleen in an asymptomatic 55-year-old woman, whose lesion was accidentally found and clinically misdiagnosed to be lymphoma. An inflammatory pseudotumor of the spleen was histopathologically diagnosed following a splenectomy. This lesion is a benign, reactive, and inflammatory process and its etiopathogenesis still remains elusive. The preoperative diagnosis is difficult and the optimal management of the asymptomastic patient with the disease is unclear. This entity should be kept in mind in the differential diagnosis of splenic space-occupying lesions. 相似文献