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Simona Puzelli Giada Rossini Marzia Facchini Gabriele Vaccari Livia Di Trani Angela Di Martino Paolo Gaibani Caterina Vocale Giovanni Cattoli Michael Bennett John W. McCauley Giovanni Rezza Maria Luisa Moro Roberto Rangoni Alba Carola Finarelli Maria Paola Landini Maria Rita Castrucci Isabella Donatelli the Influenza Task Force 《Emerging infectious diseases》2014,20(10):1745-1749
During an influenza A(H7N7) virus outbreak among poultry in Italy during August–September 2013, infection with a highly pathogenic A(H7N7) avian influenza virus was diagnosed for 3 poultry workers with conjunctivitis. Genetic analyses revealed that the viruses from the humans were closely related to those from chickens on affected farms. 相似文献
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Luigi Aloe Patrizia Bianchi Alberto De Bellis Marzia Soligo Maria Luisa Rocco 《中国神经再生研究》2014,9(10):1025-1030
The purpose of this work was to investigate whether, by intranasal administration, the nerve growth factor bypasses the blood-brain barrier and turns over the spinal cord neurons and if such therapeutic approach could be of value in the treatment of spinal cord injury. Adult Sprague-Dawley rats with intact and injured spinal cord received daily intranasal nerve growth factor administration in both nostrils for 1 day or for 3 consecutive weeks. We found an in-creased content of nerve growth factor and enhanced expression of nerve growth factor receptor in the spinal cord 24 hours after a single intranasal administration of nerve growth factor in healthy rats, while daily treatment for 3 weeks in a model of spinal cord injury improved the deifcits in locomotor behaviour and increased spinal content of both nerve growth factor and nerve growth factor receptors. These outcomes suggest that the intranasal nerve growth factor bypasses blood-brain barrier and affects spinal cord neurons in spinal cord injury. They also suggest exploiting the possible therapeutic role of intranasally delivered nerve growth factor for the neuroprotection of damaged spinal nerve cells. 相似文献
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Cerebral vein thrombosis in patients with Philadelphia‐negative myeloproliferative neoplasms An European Leukemia Net study 下载免费PDF全文
Ida Martinelli Valerio De Stefano Alessandra Carobbio Maria L. Randi Claudia Santarossa Alessandro Rambaldi Maria C. Finazzi Francisco Cervantes Eduardo Arellano‐Rodrigo Serena Rupoli Lucia Canafoglia Alessia Tieghi Luca Facchini Silvia Betti Alessandro M. Vannucchi Lisa Pieri Rossella Cacciola Emma Cacciola Agostino Cortelezzi Alessandra Iurlo Enrico M. Pogliani Elena M. Elli Antonio Spadea Tiziano Barbui 《American journal of hematology》2014,89(11):E200-E205
To investigate the characteristics and clinical course of cerebral vein thrombosis (CVT) in patients with myeloproliferative neoplasms (MPN) we compared 48 patients with MPN and CVT (group MPN‐CVT) to 87 with MPN and other venous thrombosis (group MPN‐VT) and 178 with MPN and no thrombosis (group MPN‐NoT) matched by sex, age at diagnosis of MPN (±5 years) and type of MPN. The study population was identified among 5,500 patients with MPN, from January 1982 to June 2013. Thrombophilia abnormalities were significantly more prevalent in the MPN‐CVT and MPN‐VT than in MPN‐NoT group (P = 0.015), as well as the JAK2 V617F mutation in patients with essential thrombocythemia (P = 0.059). Compared to MPN‐VT, MPN‐CVT patients had a higher rate of recurrent thrombosis (42% vs. 25%, P = 0.049) despite a shorter median follow‐up period (6.1 vs. 10.3 years, P = 0.019), a higher long‐term antithrombotic (94% vs. 84%, P = 0.099) and a similar cytoreductive treatment (79% vs. 70%, P = 0.311). The incidence of recurrent thrombosis was double in MPN‐CVT than in MPN‐VT group (8.8% and 4.2% patient‐years, P = 0.022), and CVT and unprovoked event were the only predictive variables in a multivariate model including also sex, blood count, thrombophilia, cytoreductive, and antithrombotic treatment (HR 1.97, 95%CI 1.05–3.72 and 2.09, 1.09–4.00, respectively). Am. J. Hematol. 89:E200–E205, 2014. © 2014 Wiley Periodicals, Inc. 相似文献
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Andrea Corbingi Idanna Innocenti Annamaria Tomasso Raffaella Pasquale Andrea Visentin Marzia Varettoni Elena Flospergher Francesco Autore Francesca Morelli Livio Trentin Gianluigi Reda Dimitar G. Efremov Luca Laurenti 《British journal of haematology》2020,190(6):901-908
The relationship between chronic lymphocytic leukaemia (CLL) and qualitative/quantitative gammaglobulin abnormalities is well established. Nevertheless, in order to better understand this kind of connection, we examined 1505 patients with CLL and divided them into four subgroups on the basis of immunoglobulin (Ig) aberrations at diagnosis. A total of 73 (4·8%), 149 (10%), 200 (13·2%) and 1083 (72%) patients were identified with IgM monoclonal gammopathy (IgM/CLL), IgG monoclonal gammopathy (IgG/CLL), hypogammaglobulinaemia (hypo-γ) and normal Ig levels (γ-normal) respectively. IgM paraprotein was significantly associated with a more advanced Binet/Rai stage and del(17p)/TP53 mutation, while IgG abnormalities correlated with a higher occurrence of trisomy 12. Patients with any type of Ig abnormality had shorter treatment-free survival (TFS) but no significant impact affecting overall survival (OS) compared to those with normal Ig levels. 相似文献
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Marco Cerrano Massimiliano Bonifacio Matteo Olivi Antonio Curti Michele Malagola Michelina Dargenio Anna Maria Scattolin Cristina Papayannidis Fabio Forghieri Carmela Gurrieri Ilaria Tanasi Patrizia Zappasodi Roberta La Starza Nicola Stefano Fracchiolla Patrizia Chiusolo Luisa Giaccone Maria Ilaria Del Principe Fabio Giglio Marzia Defina Claudio Favre Carmelo Rizzari Barbara Castella Giovanni Pizzolo Felicetto Ferrara Sabina Chiaretti Robin Fo 《Haematologica》2022,107(4):996