Treatment of ejaculation disorders by midodrine (Gutron) per os. Retrospective study of about 16 subjects]

PURPOSE: We evaluate the efficiency and side effects of midodrine in the treatment of sperm transport disturbances. MATERIALS AND METHODS: This retrospective study concerned patients addressed in Andrologia Department between 1995 and 2002 for treatment of sperm transport disturbances by administration of Midodrine per os (from 2.5 to 20 mg). Anterograde and retrogrades ejaculates (in urine sample) were examined. RESULTS: Sixteen patients (middle age of 36 years) were included: 12 neurologic lesions (central or peripheral, with 3 diabetes), four post-surgical (urologic and digestive) ejaculatory incompetence. One patient obtained anterior and retrograde ejaculation, two patients obtained anterior ejaculation and six retrograde ejaculations by midodrine per os. This treatment was inefficient in eight subjects. Side effects were exceptional. DISCUSSION: We obtained anterior or retrograde ejaculation in half of our population. The success was more important in patients with central neurologic injuries, diabetes or post-surgical troubles. In peripheral neurologic injuries, midodrine per os (maximal dose of 20 mg) was ineffective. CONCLUSION: Our study demonstrates the efficiency and good tolerance of midodrine per os for treatment of sperm transport disturbances.     

Fragrance material review on cinnamyl alcohol.

A toxicologic and dermatologic review of cinnamyl alcohol when used as a fragrance ingredient is presented.     

Role of burst activity in attribute detection by visual neurons of the cat cortex

The temporal structure of neuronal responses has been investigated in the Clare-Bishop area of the cat cortex. Stationary and moving slit and moving spot have been used for stimulation. It was found that orientational and directional selectivity was determined mainly by the number of clustered impulses and the number of clusters. A closed-loop model for features detection which is able to interpret clustered activity is presented.     

Subacute sclerosing panencephalitis. Apropos of 8 cases, with one developing over a 13-year period

The subacute sclerosing panencephalitis is one of the few child dementiae. An eight cases study is the opportunity of analysing the clinical, electrical and evolutive particularities of this very serious prognosis disease. The circumstantial comment of a thirteen-year-followed-case illustrates the clinical features, the electrical evolution, and the late C.T. scan aspects.     

Arterial complications of total knee replacement. The Australian experience

Arterial complications occurring in association with knee replacement surgery are rare, even though most patients having this operation are elderly and therefore more likely to have peripheral vascular disease. We report a patient who developed an arterial complication during the course of a knee replacement operation, as well as the results of a survey of Fellows of the Australian Orthopaedic Association. Recommendations to minimise this serious complication are proposed.