全文获取类型
收费全文 | 192篇 |
免费 | 10篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 11篇 |
妇产科学 | 11篇 |
基础医学 | 31篇 |
口腔科学 | 3篇 |
临床医学 | 26篇 |
内科学 | 28篇 |
皮肤病学 | 2篇 |
神经病学 | 20篇 |
特种医学 | 5篇 |
外科学 | 12篇 |
综合类 | 1篇 |
预防医学 | 10篇 |
眼科学 | 1篇 |
药学 | 12篇 |
肿瘤学 | 25篇 |
出版年
2023年 | 4篇 |
2022年 | 1篇 |
2021年 | 3篇 |
2020年 | 2篇 |
2019年 | 4篇 |
2018年 | 6篇 |
2017年 | 3篇 |
2016年 | 5篇 |
2015年 | 3篇 |
2014年 | 2篇 |
2013年 | 6篇 |
2012年 | 20篇 |
2011年 | 20篇 |
2010年 | 11篇 |
2009年 | 3篇 |
2008年 | 17篇 |
2007年 | 12篇 |
2006年 | 18篇 |
2005年 | 15篇 |
2004年 | 19篇 |
2003年 | 15篇 |
2002年 | 9篇 |
2000年 | 1篇 |
1998年 | 1篇 |
1996年 | 2篇 |
1986年 | 2篇 |
排序方式: 共有204条查询结果,搜索用时 15 毫秒
61.
Ruano R Benachi A Joubin L Aubry MC Thalabard JC Dumez Y Dommergues M 《BJOG : an international journal of obstetrics and gynaecology》2004,111(5):423-429
OBJECTIVE: To evaluate the potential of three-dimensional ultrasound to predict outcome in congenital diaphragmatic hernia. DESIGN: Prospective observational study. SETTING: Tertiary care centre. POPULATION: Twelve cases of isolated congenital diaphragmatic hernia (11 left-sided, 1 right-sided) and 109 controls. METHODS: Fetal lung volume was assessed by three-dimensional ultrasound using the technique of rotation of the multiplanar imaging. In the control fetuses, a logistic transformation was performed to correlate fetal lung volume with gestational age, and the confidence interval was obtained with a bootstrap resampling. A mathematical equation was then obtained allowing calculation of the expected fetal lung volume as a function of gestational age. In fetuses with congenital diaphragmatic hernia, the observed/expected lung volume ratio was compared with postnatal outcome. MAIN OUTCOME MEASURES: Neonatal mortality and pulmonary hypoplasia, which was defined as lung/body weight ratios less than 0.012. RESULTS: The expected fetal lung volume was derived from the mathematical equation: Fetal lung volume (mL) = exp (4.72/(1 + exp ((20.32 - gestational age in weeks)/6.05))). The observed/expected fetal lung volume ratio was significantly lower in the congenital diaphragmatic hernia group (median: 0.34, range: 0.16-0.66), than in the control group (median: 1.02, range: 0.62-1.97, P < 0.0001). The distribution of this ratio was significantly downshifted in the infants with congenital diaphragmatic hernia who died (median: 0.19, range: 0.18-0.66) compared with survivors (median: 0.44, range: 0.36-0.66, P= 0.04). The observed/expected fetal lung volume ratio was also correlated with the postmortem lung/body weight ratio. CONCLUSION: In isolated congenital diaphragmatic hernia, fetal lung volume measurement by three-dimensional ultrasound is a potential predictor for pulmonary hypoplasia and postnatal outcome. 相似文献
62.
Segeth MP Bonnefoy A Brönstrup M Knauf M Schummer D Toti L Vértesy L Wetzel-Raynal MC Wink J Seibert G 《The Journal of antibiotics》2003,56(2):114-122
The coprophilic ascomycete Coniochaeta ellipsoidea DSM 13856 forms the new antibiotic coniosetin (1) in surface cultures grown on a medium containing malt extract and oatmeal. The structure of the compound C25H35NO4, MW 413, was determined by 2D-NMR and mass spectrometric studies. Coniosetin belongs to the class of tetramic acids; it consists of a substituted aliphatic bicyclic ring system linked to a tetramic acid subunit through a carbonyl center. The absolute configuration was determined by measuring its circular dichroism spectrum and comparing the data with those of equisetin. Coniosetin has a pronounced antibacterial and antifungal action, inhibiting even multi drug-resistant strains of Staphylococcus aureus at a concentration of 0.3 microg/ml, though it is inactive against Gram-negative bacteria. 相似文献
63.
64.
Gandemer V Le Deley MC Dollfus C Auvrignon A Bonnaure-Mallet M Duval M De Lumley L Hartmann O Mechinaud F Sirvent N Orbach D Doireau V Boutard P Dalle JH Reguerre Y Pautard B Aubier F Schneider P Suc A Couillaut G Schmitt C;Pain task force of the SFCE 《Journal of pediatric hematology/oncology》2007,29(2):86-94
The properties of saliva led us to hypothesize that the salivary flow increase induced by gum chewing might protect the oral mucosa from lesions due to cancer chemotherapy. We conducted a multicenter randomized trial to evaluate the efficacy of chewing gum in preventing oral mucositis in 145 children receiving chemotherapy regimens expected to induce WHO grade 3-4 oral mucositis in at least 30% of patients. Patients were allocated at random to standard oral care with or without 5 gum pieces per day. No overall reduction in severe oral mucositis occurred in the gum arm (51%) compared with the standard arm (44%). VIDE, COPADM, and multidrug intensive chemotherapy caused severe oral mucositis in 75% of patients in both arms. In patients receiving less toxic regimens, a decrease in WHO grade 1-4 oral mucositis was noted in the gum arm compared with the standard arm (49% vs. 72%, P=0.03). In the multivariate analysis, the risk of oral mucositis was related only to the type of chemotherapy regimen, suggesting that further strategies for preventing oral mucositis could be mainly based on these criteria. 相似文献
65.
66.
Heterogeneity and frequency of movement disorders in juvenile and adult-onset Niemann-Pick C disease
Mathieu Anheim Ouhaïd Lagha-Boukbiza Marie-Céline Fleury-Lesaunier Maria-Paola Valenti-Hirsch Edouard Hirsch Hélène Gervais-Bernard Emmanuel Broussolle Stéphane Thobois Marie T. Vanier Philippe Latour Christine Tranchant 《Journal of neurology》2014,261(1):174-179
Niemann-Pick type C disease (NPC) is a recessive neurolipidosis. We report five adolescent and adult NPC cases to underscore the frequency and heterogeneity of movement disorders in NPC. Clinical, morphologic, biochemical and genetic study was performed in the five patients. Disease onset was between 8 and 50 years. Movement disorders were present in all cases, were heterogeneous and often combined [cerebellar ataxia (5/5), myoclonus (3/5), dystonia (2/5), chorea (1/5) and tremor (1/5)] and were the first sign in 4/5. Two patients were reported to have no vertical supranuclear gaze palsy (VSGP) at the first examination. Two patients experienced acute neuropsychiatric signs leading to death in one case due to myoclonic storm. Filipin staining was always positive. Two NPC1 mutations were identified in three patients, only one in two siblings. NPC should be considered in case of unexplained movement disorders, even when VSGP or cataplexy are not reported. Filipin staining remains a strong support for the diagnosis. Treatment with miglustat should be considered which is currently the only approved disease-specific treatment of NPC in children and adults. 相似文献
67.
The specificity of adolescence and early adulthood with people suffering from cancer requires adapted and specific care by nursing teams. The paediatric oncology and medical oncology teams at the Institut Curie in Paris, faced with such issues, have been working more closely together to create a special unit for 15-25 year olds. 相似文献
68.
69.
70.
Garnier F Courouble M Denis F Ploy MC 《Diagnostic microbiology and infectious disease》2011,69(3):280-282
Between 2003 and 2007, we recovered 21 serogroup C Neisseria meningitidis isolates in the Haute-Vienne county of France. Multilocus sequence typing showed that 20 isolates belonged to the ST-11 clonal complex (8 to clone ET-15 and 12 to clone ET-37) and 1 to the ST-8 clonal complex. 相似文献