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41.
Wrobel G Mauguen A Rosolen A Reiter A Williams D Horibe K Brugières L Le Deley MC;European Inter-Group for Childhood Non-Hodgkin Lymphoma 《Pediatric blood & cancer》2011,56(7):1071-1077
Background
ALCL99 protocol including six courses of chemotherapy derived from the NHL‐BFM protocol is widely used for the treatment of paediatric anaplastic large‐cell lymphoma. In the ALCL99 trial, patients were randomised to receive MTX 1 g/m2 in 24 hr with intrathecal injection (MTX1) versus MTX 3 g/m2 in 3 hr without intrathecal (MTX3); then to receive or not vinblastine (high‐risk patients). The present study provides information about the acute adverse reactions (ARs) during the six courses of the ALCL99 treatment, assesses risk factors for ARs and evaluates the risk of overweight related to treatment.Methods
Data concerning ARs were assessed using CTCv2 and analysed overall and according to the type of course.Results
Between 1999 and 2005, 352 patients were recruited. Toxicity assessed after 2050 courses included grade 4 neutropaenia (70% of courses), grade 3–4 stomatitis (13%), grade 3–4 transaminase elevation (10%) and grade 3–4 infection (5%). Four patients (1%) died of toxicity. The toxicity profile differed between courses‐A (significantly more haematological toxicity) and courses‐B (significantly more stomatitis). The percentage of ARs was higher after the first course than after subsequent courses. Severe toxicity was more frequent after MTX1 than after MTX3 courses but did not differ between courses with or without vinblastine. Overall 20% of patients had a weight gain exceeding 20%.Conclusions
The high rate of acute toxicity should be considered when using the ALCL99 protocol. Chemotherapy including MTX 3 g/m2 in 3 hr was less toxic than the same regimen with MTX 1 g/m2 in 24 hr. Adding vinblastine did not increase the risk of toxicity. Pediatr Blood Cancer 2011;56:1071–1077. © 2011 Wiley‐Liss, Inc. 相似文献42.
Noninvasive fluorine-19 NMR study of fluoropyrimidine metabolism in cell cultures of human pancreatic and colon adenocarcinoma 总被引:1,自引:0,他引:1
Marie-C. Malet-Martino Françoise Faure Jean-Pierre Vialaneix Claude Palevody Etienne Hollande Robert Martino 《Cancer chemotherapy and pharmacology》1986,18(1):5-10
Summary Fluorine-19 NMR spectrometry was used to monitor the metabolism of two antineoplastic fluoropyrimidines, 5-fluorouracil (5FU) and 5-deoxy-5-fluorouridine (5dFUrd), in cell cultures of human pancreatic (Capan-1) and colon (HT-29) adenocarcinoma. The preliminary results showed, for the two tumor cell lines treated with 5FU, the presence in nonperfused cells of three signals corresponding to intracellular metabolites: 5FU, F-nucleotides and F-nucleosides. When the cells were perfused only the signals of F-nucleotides and 5FU were present. The F-nucleosides observed during the analysis of the nonperfused cells came from the conversion of F-nucleotides. During the NMR recording of Capan-1 cells at 37 °C the first metabolite of the catabolic pathway of 5FU, 5,6-dihydro-5-fluorouracil, occurred. At the beginning of the NMR recording of Capan-1 cells treated with 5dFUrd, two signals corresponding to F-nucleotides and F-nucleosides (consistent with 5dFUrd) were observed; during the analysis, a supplementary signal corresponding to 5FU appeared. Even after pretreatment with methotrexate the signal of 5FU incorporated into RNA was not detected. Our experiments, performed in attempts to observe the signal of the ternary complex between thymidylate synthetase (TS), 5-fluoro-2-deoxyuridine-5-monophosphate (FdUMP) and 5,10-methylene-tetrahydrofolate (5,10-CH2FH4), allowed detection in some cases of a broad signal, whose chemical shift was similar to that reported in the literature following incubation of TS with FdUMP and 5,10-CH2FH4, but our results were not always reproducible.This study was supported by grants from Université Paul Sabatier, Conseil Régional Midi-Pyrénées-CNRS and Caisse Nationale de l'Assurance Maladie des Travailleurs Salariés (INSERM) 相似文献
43.
Christine Rousset-Jablonski Fréderic Selle Elodie Adda-Herzog François Planchamp Lise Selleret Christophe Pomel Nathalie Chabbert-Buffet Emile Daraï Patricia Pautier Florence Trémollières Frederic Guyon Roman Rouzier Valérie Laurence Nicolas Chopin Cécile Faure-Conter Enrica Bentivegna Marie-Cécile Vacher-Lavenu Catherine Lhomme Isabelle Ray-Coquard 《Bulletin du cancer》2018,105(3):299-314
44.
Marie-Cécile Blanchet Caroline Mesmann Mazen Yanes Sébastien Lepage Denis Marion Patrick Gelas Christian Gouillat 《Obesity surgery》2010,20(12):1727-1733
The number of bariatric operations performed each year is increasing. As a result, a rising number of patients in possible
need for revisional surgery are referred to bariatric surgeons. But the standard methods of evaluation are often insufficient,
and the best strategy remains difficult to choose. In our centre, we have developed 3D gastric computed tomography with air
(3D-GCT). The aim of this pilot study was to assess the usefulness of this new image modality as an aid in the decision-making
process in patients with failure or complications after bariatric surgery. Twenty patients referred for failure or complications
after various bariatric procedures were included in the study. 3D-GCT was performed on a multidetector CT scanner after absorption
of effervescent salt diluted in 10 ml of water and IV injection of butylscopolamine. Thin-slice data were transferred to a
dedicated 3D workstation creating three-dimensional volume-rendering images of the oesophagus, gastric cavities and anastomoses.
The volume of the gastric pouches and the diameter of stoma or anastomoses were measured. No failure or complications were
observed. In all patients, 3D-GCT resulted in very impressive precise 3D images of post-surgical anatomy of the stomach. Imaging
findings allowed us to identify or to eliminate the common complications of each procedure with a good accuracy, resulting
in an aid to choose the best strategy in each patient. In conclusion, our pilot study suggests that 3D-GCT is useful as a
decision-making aid in patients with failure or complications after bariatric surgery. 相似文献
45.
46.
Martial Mallaret Mathilde Renaud Claire Redin Nathalie Drouot Jean Muller Francois Severac Jean Louis Mandel Wahiba Hamza Traki Benhassine Lamia Ali-Pacha Meriem Tazir Alexandra Durr Marie-Lorraine Monin Cyril Mignot Perrine Charles Lionel Van Maldergem Ludivine Chamard Christel Thauvin-Robinet Vincent Laugel Lydie Burglen Patrick Calvas Marie-Céline Fleury Christine Tranchant Mathieu Anheim Michel Koenig 《Journal of neurology》2016,263(7):1314-1322
47.
48.
Kriegel I Desruennes E Douard MC Grange C Renaudin JM Meyer G Scrobohaci ML Kassab-Chahmi D Bosquet L Cajfinger F Desmurs-Clavel H Elias A Elalamy I Farge-Bancel D Hocini H Lévesque H Mahé I Mismetti P Pavic M Quéré I Le Gal G Debourdeau P 《Annales fran?aises d'anesthèsie et de rèanimation》2008,27(6):521-533
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