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Background
The aim of this study was to assess the clinico biochemical spectrum of hypothyroidism and the relative importance of thyroid function tests, clinical symptoms and signs in thyroid dysfunction.Methods
A retrospective study was done and 1702 requisitions for screening of hypothyroidism were analysed. The clinical presentation of cases was correlated with the results of thyroid profile tests.Results
31.5% of the 1702 cases referred had thyroid dysfunction in the form of subclinical or overt hypothyroidism. In the hypothyroid group generalized weakness, weight gain and myxoedema was common. In cases of primary infertility and depression, subclinical and overt hypothyroidism was high (40% and 45.8% respectively). The average age of females with subclinical hypothyroidism was 30.8 years, 5.4 years less than females with overt hypothyroidism.Conclusion
We conclude that hypothyroidism is common and often under-diagnosed. Therefore routine evaluation of female patients with weight gain, generalized weakness, infertility, depression and mood changes should include thyroid profile.Key Words: Hypothyroidism, Thyroid profile, Screening, Infertility, Depression 相似文献Introduction
The National Conference (NATCON) of Anatomical Society of India (ASI) is the preeminent meeting of anatomists in South-east Asia region. In the present study we undertook a quantitative assessment of the abstracts presented orally in three NATCON of ASI held between 2013 and 2015, with regards to rate of subsequent publication in peer reviewed journals.Methods
A detailed electronic literature search was undertaken in indexation databases such as Medline, PubMed, Scopus, EMBASE, Cochrane Library, CINAHL & Google Scholar to determine whether abstract has been published or not. For abstracts eventually published we noted the time-interval from presentation to publication and the impact factor of the journal when available.Results
The effective abstract-to-publication ratio (EAPR) for the three NATCON’s from 2013 to 2015 were noted as 0.034, 0.041 & 0.024 respectively. Survival plot analysis revealed probability of publication increases with time and time-interval adjusted survival plot analysis showed similar shape of curves for all three NATCON’s. Median impact factor of journals for the three NATCON’s were found to be similar with no statistical significance of the difference in values (Kruskal WallisP?=? 0.883).Discussion
Documented EAPR values could be used as benchmark to assess quality of future anatomy conferences in India. Analysis of observations showed that probability for improvement in publication rates for NATCON is on the higher side and there is uniformity in standard of research presented in NATCON. Publication rates could further improve with workshops dedicated towards cultivation of research output among young researchers. 相似文献Methods: A retrospective, observational, cohort study using population-based data and medical record review. The patient database of a large, regional health maintenance organization (Northern California Kaiser Permanente) was searched, and the study population consisted of 1,042,351 people over a 1-year study period from 1 July 1998 through 30 June 1999. Only ocular HSV cases with definitive clinical or laboratory confirmed diagnoses were included. Active and inactive cases were included, however only active cases were used in incidence and prevalence calculations. Bilateral disease was counted as one case. Newly diagnosed cases were followed for recurrence from initial presentation through 31 December 2002.
Results: After chart review of 322 possible cases, 71 new cases and 59 previously diagnosed active cases of ocular HSV were confirmed. This resulted in an incidence rate of 6.8 new cases/100,000 person-years (95% confidence interval, CI, 5.3–8.6). Incidence increased with age, and rates were highest in people over 75 years of age (p?<?0.001). The recurrence rate in new cases was 18% for the 3-year follow-up time, and was equal to 5% per year (95% CI 3–9%).
Conclusion: The incidence and prevalence of ocular herpes simplex in this study was lower than previously reported. Incidence increased with age, and there were significantly higher rates in the older population. 相似文献