全文获取类型
收费全文 | 2381篇 |
免费 | 160篇 |
国内免费 | 76篇 |
专业分类
耳鼻咽喉 | 37篇 |
儿科学 | 93篇 |
妇产科学 | 42篇 |
基础医学 | 246篇 |
口腔科学 | 68篇 |
临床医学 | 236篇 |
内科学 | 526篇 |
皮肤病学 | 162篇 |
神经病学 | 190篇 |
特种医学 | 144篇 |
外国民族医学 | 3篇 |
外科学 | 209篇 |
综合类 | 131篇 |
一般理论 | 10篇 |
预防医学 | 184篇 |
眼科学 | 120篇 |
药学 | 139篇 |
中国医学 | 1篇 |
肿瘤学 | 76篇 |
出版年
2021年 | 25篇 |
2019年 | 26篇 |
2018年 | 32篇 |
2017年 | 25篇 |
2016年 | 37篇 |
2015年 | 34篇 |
2014年 | 43篇 |
2013年 | 62篇 |
2012年 | 99篇 |
2011年 | 101篇 |
2010年 | 61篇 |
2009年 | 67篇 |
2008年 | 87篇 |
2007年 | 147篇 |
2006年 | 114篇 |
2005年 | 90篇 |
2004年 | 101篇 |
2003年 | 89篇 |
2002年 | 64篇 |
2001年 | 76篇 |
2000年 | 83篇 |
1999年 | 59篇 |
1998年 | 47篇 |
1997年 | 33篇 |
1996年 | 50篇 |
1995年 | 29篇 |
1994年 | 22篇 |
1993年 | 27篇 |
1992年 | 50篇 |
1991年 | 46篇 |
1990年 | 50篇 |
1989年 | 51篇 |
1988年 | 37篇 |
1987年 | 36篇 |
1986年 | 55篇 |
1985年 | 51篇 |
1984年 | 30篇 |
1983年 | 31篇 |
1981年 | 27篇 |
1979年 | 27篇 |
1978年 | 24篇 |
1977年 | 33篇 |
1976年 | 29篇 |
1975年 | 29篇 |
1974年 | 24篇 |
1973年 | 30篇 |
1972年 | 28篇 |
1971年 | 27篇 |
1970年 | 26篇 |
1969年 | 22篇 |
排序方式: 共有2617条查询结果,搜索用时 15 毫秒
71.
Newly Developed Chronic Conditions and Changes in Health‐Related Quality of Life in Postmenopausal Women
下载免费PDF全文
![点击此处可从《Journal of the American Geriatrics Society》网站下载免费的PDF全文](/ch/ext_images/free.gif)
72.
David J. Margolis MD PhD Michelle Hampton BA Ole Hoffstad MS D. Scot Malay DPM MSCE Stephen Thom MD PhD 《Wound repair and regeneration》2015,23(3):299-301
The adherence by patients to diabetic foot ulcer therapy is often difficult. The goal of this study was to begin to understand how a patient's health literacy affects their foot ulcer management decisions. Initially using a cross‐sectional study design, we evaluated diabetics with foot ulcers within 4 weeks of being asked to participate in a longitudinal study. We assessed health literacy using measures of general health literacy, diabetes health literacy, diabetes self‐efficacy, and diabetes numeracy. Individuals enrolled in the study had higher health literacy based on the Short Test of Functional Health Literacy in Adults [33.8 (SD 2.3) versus 27.3 (SD 9.6); p = 0.009] as compared to individuals who previously declined an invitation to enroll in the study. Furthermore, patients with lower Short Test of Functional Health Literacy in Adults scores had larger (p = 0.04) and older (p = 0.125) wounds (markers for poorer prognosis). Other measures of literacy showed similar results. In conclusion, those with diminished health literacy were less likely to enroll in an investigational study and had wounds that were less likely to heal. 相似文献
73.
Junctophilin 3 (JPH3) expansion mutations causing Huntington disease like 2 (HDL2) are common in South African patients with African ancestry and a Huntington disease phenotype
下载免费PDF全文
![点击此处可从《American journal of medical genetics. Part B, Neuropsychiatric genetics》网站下载免费的PDF全文](/ch/ext_images/free.gif)
74.
75.
76.
Archin NM Vaidya NK Kuruc JD Liberty AL Wiegand A Kearney MF Cohen MS Coffin JM Bosch RJ Gay CL Eron JJ Margolis DM Perelson AS 《Proceedings of the National Academy of Sciences of the United States of America》2012,109(24):9523-9528
HIV type 1 (HIV-1) persists within resting CD4(+) T cells despite antiretroviral therapy (ART). To better understand the kinetics by which resting cell infection (RCI) is established, we developed a mathematical model that accurately predicts (r = 0.65, P = 2.5 × 10(-4)) the initial frequency of RCI measured about 1 year postinfection, based on the time of ART initiation and the dynamic changes in viremia and CD4(+) T cells. In the largest cohort of patients treated during acute seronegative HIV infection (AHI) in whom RCI has been stringently quantified, we found that early ART reduced the generation of latently infected cells. Although RCI declined after the first year of ART in most acutely infected patients, there was a striking absence of decline when initial RCI frequency was less than 0.5 per million. Notably, low-level viremia was observed more frequently as RCI increased. Together these observations suggest that (i) the degree of RCI is directly related to the availability of CD4(+) T cells susceptible to HIV, whether viremia is controlled by the immune response and/or ART; and (ii) that two pools of infected resting CD4(+) T cells exist, namely, less stable cells, observable in patients in whom viremia is not well controlled in early infection, and extremely stable cells that are established despite early ART. These findings reinforce and extend the concept that new approaches will be needed to eradicate HIV infection, and, in particular, highlight the need to target the extremely small but universal, long-lived latent reservoir. 相似文献
77.
78.
Ann V. Schwartz Eric Vittinghoff Karen L. Margolis Lesley M. Scibora Lisa Palermo Walter T. Ambrosius Trisha F. Hue Kristine E. Ensrud 《Calcified tissue international》2013,92(5):477-486
Factors that contribute to bone fragility in type 2 diabetes are not well understood. We assessed the effects of intensive glycemic control, thiazolidinediones (TZDs), and A1C levels on bone geometry and strength at the radius and tibia. In a substudy of the Action to Control Cardiovascular Risk in Diabetes trial, peripheral quantitative computed tomographic (pQCT) scans of the radius and tibia were obtained 2 years after randomization on 73 participants (intensive n = 35, standard n = 38). TZD use and A1C levels were measured every 4 months during the trial. Effects of intervention assignment, TZD use, and A1C on pQCT parameters were assessed in linear regression models. Intensive, compared with standard, glycemic control was associated with 1.3 % lower cortical volumetric BMD at the tibia in men (p = 0.02) but not with other pQCT parameters. In women, but not men, each additional year of TZD use was associated with an 11 % lower polar strength strain index (SSIp) at the radius (p = 0.04) and tibia (p = 0.002) in models adjusted for A1C levels. In women, each additional 1 % increase in A1C was associated with an 18 % lower SSIp at the ultradistal radius (p = 0.04) in models adjusted for TZD use. There was no consistent evidence of an effect of intensive, compared with standard, glycemic control on bone strength at the radius or tibia. In women, TZD use may reduce bone strength at these sites. Higher A1C may also be associated with lower bone strength at the radius, but not tibia, in women. 相似文献
79.
D'Anna LH Margolis AD Warner L Korosteleva OA O'Donnell L Rietmeijer CA Klausner JD Nomura W Malotte CK;Safe City Study Group 《AIDS care》2012,24(8):1028-1038
Our research aims were to: (1) assess the prevalence of two condom use problems: breakage or slippage and partial use (delayed application or early removal) among men who have sex with men (MSM) seeking services in urban US STD clinics; and (2) examine the association between these condom use problems and participant, partner and partnership characteristics. Analysis was restricted to HIV-negative MSM who reported having anal sex at least once in the preceding 3 months and who completed both the baseline and 3 month follow-up assessments. Two models were fitted using the generalized estimating equations (GEE) approach. A total of 263 MSM (median age=32 years) reported 990 partnerships. Partnerships with no condom use 422 (42.6%) were excluded. Thus, 207 MSM and 568 partnerships were included. Among condom users, 100% use was reported within 454 partnerships (79.9%) and <100% within 114 (20.1%), and 21(3.7%) reported both condom use problems, 25 (4.4%) reported only breakage, 67 (11.8%) reported only partial use, and 455 (80.1%) reported no errors. The breakage or slippage and partial use rates per condom used were 3.4% and 11.2%, respectively. A significantly higher rate of breakage or slippage occurred among non-main partnerships. Characteristics associated with increased odds for condom breakage or slippage were: lower education level (OR=2.78; CI: 1.1-7.5), non-main partner status (OR=4.1; CI: 1.5-11.7), and drunk or high during sex (OR=2.0; CI: 1.1-3.8), and for partial use: lower education level (OR=2.6; CI: 1.0-6.6), perceived partner sexually transmitted infections (STI) risk (OR=2.4; CI: 1.3-4.2), and inconsistent condom use (OR=3.7; CI: 2.0-6.6). A high percentage of MSM partnerships reported no condom use and among condom users, a sizable proportion did not use them consistently or correctly. MSM may benefit from interventions designed to increase proficiency for condom use with a particular focus on the behaviors of inconsistent and partial condom use. 相似文献