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Kathrin Witmer Farah A. Dahalan Michael J. Delves Sabrina Yahiya Oliver J. Watson Ursula Straschil Darunee Chiwcharoen Boodtee Sornboon Sasithon Pukrittayakamee Richard D. Pearson Virginia M. Howick Mara K. N. Lawniczak Nicholas J. White Arjen M. Dondorp Lucy C. Okell Kesinee Chotivanich Andrea Ruecker Jake Baum 《Antimicrobial agents and chemotherapy》2021,65(1)
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Crutel Véronique Lambert Estelle Penelaud Pierre-François Albarrán Severo Cristina Fuentes Joaquin Rosier Antoine Hervás Amaia Marret Stéphane Oliveira Guiomar Parellada Mara Kyaga Simon Gouttefangeas Sylvie Bertrand Marianne Ravel Denis Falissard Bruno 《Journal of autism and developmental disorders》2021,51(8):2973-2973
Journal of Autism and Developmental Disorders - The author of the article would like to add a video abstract as a supplementary material for a published article. The supplementary file is published... 相似文献
55.
Mara Cerqueiro Bybrant Lena Grahnquist Eva Örtqvist Cecilia Andersson Gun Forsander Helena Elding Larsson 《Autoimmunity》2013,46(5):221-227
AbstractObjectives: This study explored the association between tissue transglutaminase autoantibody (tTGA), high-risk human leucocyte antigen (HLA) genotypes and islet autoantibodies in children with newly diagnosed type 1 diabetes (T1D).Patients and methods: Dried blood spots and serum samples were taken at diagnosis from children <18?years of age participating in Better Diabetes Diagnosis (BDD), a Swedish nationwide prospective cohort study of children newly diagnosed with T1D. We analyzed tTGA, high-risk HLA DQ2 and DQ8 (DQX is neither DQ2 nor DQ8) and islet auto-antibodies (GADA, IA-2A, IAA, and three variants of Zinc transporter; ZnT8W, ZnT8R, and ZnT8QA).Results: Out of 2705 children diagnosed with T1D, 85 (3.1%) had positive tTGA and 63 (2.3%) had borderline values. The prevalence of tTGA was higher in children with the HLA genotypes DQ2/2, DQ2/X or DQ2/8 compared to those with DQ8/8 or DQ8/X (p?=?.00001) and those with DQX/X (p?≤?.00001). No significant differences were found in relation to islet autoantibodies or age at diagnosis, but the presence of tTGA was more common in girls than in boys (p?=?.018).Conclusion: tTGA at T1D diagnosis (both positive and borderline values 5.4%) was higher in girls and in children homozygous for DQ2/2, followed by children heterozygous for DQ2. Only children with DQ2 and/or DQ8 had tTGA. HLA typing at the diagnosis of T1D can help to identify those without risk for CD. 相似文献
56.
Farah Breno Quintella do Prado Wagner Luiz Malik Neal Lofrano-Prado Mara Cristina de Melo Paulo Henrique Botero Joao Paulo Cucato Gabriel Grizzo de Almeida Correia Marilia Ritti-Dias Raphael Mendes 《Sport Sciences for Health》2021,17(2):441-447
Sport Sciences for Health - Social isolation due to the coronavirus disease 2019 (COVID-19) pandemic has reduced physical activity levels in both men and women. The identification of barriers to... 相似文献
57.
Miguel ngel Hernndez‐Rodríguez Ermengol Sempere‐Verdú Caterina Vicens‐Caldentey Francisca Gonzlez‐Rubio Flix Miguel‐García Vicente Palop‐Larrea Ramn Orueta‐Snchez
scar Esteban‐Jimnez Mara Sempere‐Manuel María Pilar Arroyo‐Anis Buenaventura Fernndez‐San Jos 《Pharmacoepidemiology and drug safety》2020,29(4):433-443
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Helen Reinhart Camargo Catarino Natália Pereira de Godoy Nayara Kastem Scharlack Lia Mara Grosso Neves Fernanda Oliveira de Gaspari de Gaspi Marcelo Augusto Marreto Esquisatto Maria Esméria Corezola do Amaral Fernanda Aparecida Sampaio Mendonça Gláucia Maria Tech dos Santos 《Lasers in medical science》2015,30(3):1069-1079
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Shannon J Ernst P Yamauchi Y Olivenstein R Lemiere C Foley S Cicora L Ludwig M Hamid Q Martin JG 《Chest》2008,133(2):420-426
BACKGROUND: Some studies of severe asthma suggest that persistence or alteration in the pattern of inflammation may be associated with the severity of the disease. Whether there are differences in the expression of the principal cytokines and chemokines relevant to eosinophilic and neutrophilic inflammation in the airway tissues of severe compared to moderate asthmatics has not been determined. The aim of this study was to compare the patterns of expression of representative T-helper (Th) type 1 (interferon [IFN]-gamma) and Th-2 cytokines (interleukin [IL]-4, IL-5) and the neutrophil- and eosinophil-associated chemokines (IL-8 and eotaxin) in the airway tissues of patients with severe and moderate asthma. METHODS: Subjects with severe asthma (n = 24) and a comparison moderate asthma group (n = 26) were assessed using spirometry, induced sputum, exhaled nitric oxide, and bronchial biopsy. The expression of proteins of interest in the epithelium and subepithelium of the airway wall was examined by immunocytochemistry. RESULTS: Subjects with severe asthma were more symptomatic, had a lower FEV(1), and had more sputum neutrophilia (p = 0.007) and eosinophilia (p = 0.001). Exhaled nitric oxide was similar between groups. IL-8 and IFN-gamma expression were increased and IL-4 expression was decreased in severe asthma compared to moderate disease (p < 0.001 for each comparison). Eotaxin and IL-5 expression did not differ between the groups. CONCLUSION: Patients with severe asthma have increases in neutrophils and eosinophils in the sputum, and differ in airway cytokine/chemokine expression from moderate asthmatics. Excess neutrophilia may be explained by increased expression of IL-8, but differences in eosinophilia do not appear to be associated with IL-5 and eotaxin expression. 相似文献