全文获取类型
收费全文 | 1596篇 |
免费 | 64篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 33篇 |
妇产科学 | 12篇 |
基础医学 | 154篇 |
口腔科学 | 29篇 |
临床医学 | 129篇 |
内科学 | 378篇 |
皮肤病学 | 21篇 |
神经病学 | 50篇 |
特种医学 | 15篇 |
外科学 | 210篇 |
综合类 | 50篇 |
一般理论 | 4篇 |
预防医学 | 82篇 |
眼科学 | 42篇 |
药学 | 288篇 |
中国医学 | 38篇 |
肿瘤学 | 128篇 |
出版年
2023年 | 13篇 |
2022年 | 43篇 |
2021年 | 61篇 |
2020年 | 26篇 |
2019年 | 47篇 |
2018年 | 42篇 |
2017年 | 53篇 |
2016年 | 39篇 |
2015年 | 40篇 |
2014年 | 77篇 |
2013年 | 113篇 |
2012年 | 115篇 |
2011年 | 120篇 |
2010年 | 76篇 |
2009年 | 43篇 |
2008年 | 87篇 |
2007年 | 106篇 |
2006年 | 83篇 |
2005年 | 90篇 |
2004年 | 74篇 |
2003年 | 73篇 |
2002年 | 76篇 |
2001年 | 24篇 |
2000年 | 17篇 |
1999年 | 27篇 |
1998年 | 5篇 |
1997年 | 7篇 |
1996年 | 14篇 |
1995年 | 6篇 |
1994年 | 8篇 |
1993年 | 7篇 |
1992年 | 7篇 |
1991年 | 4篇 |
1990年 | 4篇 |
1989年 | 5篇 |
1988年 | 4篇 |
1987年 | 3篇 |
1986年 | 7篇 |
1985年 | 3篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1977年 | 1篇 |
1975年 | 1篇 |
1974年 | 2篇 |
1973年 | 2篇 |
1969年 | 2篇 |
1968年 | 3篇 |
1962年 | 1篇 |
排序方式: 共有1666条查询结果,搜索用时 31 毫秒
51.
Mansour Adam Mahmoud Yazeed Alswaida Thamir Alshammari Tahir Mehmood Khan Alian Alrasheedy Mohamad Azmi Hassali Hisham Aljadhey 《Saudi Pharmaceutical Journal》2014,22(5):411-418
Objective
To assess community pharmacists’ knowledge, behaviors and experiences relating to Adverse Drug Reaction (ADR) reporting in Saudi Arabia.Methods
A cross-sectional study was conducted using a validated self-administered questionnaire. A convenience sample of 147 community pharmacists working in community pharmacies in Riyadh, Saudi Arabia.Results
The questionnaire was distributed to 147 pharmacists, of whom 104 responded to the survey, a 70.7% response rate. The mean age of participants was 29 years. The majority (n = 101, 98.1%) had graduated with a bachelorette degree and worked in chain pharmacies (n = 68, 66.7%). Only 23 (22.1%) said they were familiar with the ADR reporting process, and only 21 (20.2%) knew that pharmacists can submit ADR reports online. The majority of the participants (n = 90, 86.5%) had never reported ADRs. Reasons for not reporting ADRs most importantly included lack of awareness about the method of reporting (n = 22, 45.9%), misconception that reporting ADRs is the duty of physician and hospital pharmacist (n = 8, 16.6%) and ADRs in community pharmacies are simple and should not be reported (n = 8, 16.6%). The most common approach perceived by community pharmacists for managing patients suffering from ADRs was to refer him/her to a physician (n = 80, 76.9%).Conclusion
The majority of community pharmacists in Riyadh have poor knowledge of the ADR reporting process. Pharmacovigilance authorities should take necessary steps to urgently design interventional programs in order to increase the knowledge and awareness of pharmacists regarding the ADR reporting process. 相似文献52.
Olivier Cussenot Karim Sighar Mansoor Mohammed Sylvain Hugonin Valérie Ondet Stéphane Larre Roger Lacave Morgan Roupret Géraldine Cancel-Tassin 《World journal of urology》2014,32(2):551-557
Introduction
Bladder carcinoma (B-TCC) is the fifth most prevalent carcinoma in the United States (US) or Europe. In addition, B-TCC is the most expensive carcinoma per patient between diagnosis and death, because of its 50–80 % recurrence rate. B-TCC is an optimal carcinoma for which to detect DNA alterations in urine, which is easily obtainable. Chromosomal aberrations in tumors have been closely related to the carcinogenesis process.Material and Methods
We developed a highly specific and sensitive oligo-CGH-array for the diagnosis and follow-up of B-TCC, based on the detection of chromosomal aberrations in urine samples. One hundred and sixty-four urine samples were analyzed. The qualitative results, including chromosomal aberrations, were obtained. Quantitative results are expressed as a percentage of chromosomal alterations on the autosomes.Results
From the urine samples, we were able to differentiate B-TCC from non-malignant conditions with an accuracy of 100 % for patients without history of B-TCC. For follow-up of B-TCC in clinical practice, at least a deletion (8p; 9p; 9q) or a cut-off of >2 % of chromosomal imbalance was considered as a positive test. According to our criteria, 100 % of high-grade tumors were diagnosed, and the sensitivity to predict positive cystoscopy was 95 % (specificity 73 %). A cut-off >9 % was a strong signature of high-grade TCC (odds ratio 53 CI 95 % 7–417; p = 0.0002).Conclusion
We developed a sensitive clinical tool for the detection of B-TCC using DNA extracted from patient urine. This tool is also able to identify low-grade B-TCC and identify high-risk patients harboring a high-grade disease. 相似文献53.
Srinivas Ganta Amit Singh Niravkumar R. Patel Joseph Cacaccio Yashesh H. Rawal Barbara J. Davis Mansoor M. Amiji Timothy P. Coleman 《Pharmaceutical research》2014,31(9):2490-2502
Purpose
Platinum-based chemotherapy is the treatment of choice for malignant epithelial ovarian cancers, but generalized toxicity and platinum resistance limits its use. Theranostic nanoemulsion with a novel platinum prodrug, myrisplatin, and the pro-apoptotic agent, C6-ceramide, were designed to overcome these limitations.Methods
The nanoemulsions, including ones with an EGFR binding peptide and gadolinium, were made using generally regarded as safe grade excipients and a high shear microfluidization process. Efficacy was evaluated in ovarian cancer cells, SKOV3, A2780 and A2780CP.Results
The nanoemulsion with particle size <150 nm were stable in plasma and parenteral fluids for 24 h. Ovarian cancer cells in vitro efficiently took up the non-targeted and EGFR-targeted nanoemulsions; improved cytotoxicity was observed for the these nanoemulsions with the latter showing a 50-fold drop in the IC50 in SKOV3 cells as compared to cisplatin alone. The addition of gadolinium did not affect cell viability in vitro, but showed relaxation times comparable to Magnevist®.Conclusion
The myrisplatin/C6-ceramide nanoemulsion synergistically enhanced in vitro cytotoxicity. An EGFR binding peptide addition further increased in vitro cytotoxicity in EGFR positive cancer cells. The diagnostic version showed MR imaging similar to the clinically relevant Magnevist® and may be suitable as a theranostic for ovarian cancer. 相似文献54.
José das Neves Francisca Araújo Fernanda Andrade Mansoor Amiji Maria Fernanda Bahia Bruno Sarmento 《Pharmaceutical research》2014,31(7):1834-1845
Purpose
To assess the potential of polymeric nanoparticles (NPs) to affect the genital distribution and local and systemic pharmacokinetics (PK) of the anti-HIV microbicide drug candidate dapivirine after vaginal delivery.Methods
Dapivirine-loaded, poly(ethylene oxide)-coated poly(epsilon-caprolactone) (PEO-PCL) NPs were prepared by a nanoprecipitation method. Genital distribution of NPs and their ability to modify the PK of dapivirine up to 24 h was assessed after vaginal instillation in a female mouse model. Also, the safety of NPs upon daily administration for 14 days was assessed by histological analysis and chemokine/cytokine content in vaginal lavages.Results
PEO-PCL NPs (180–200 nm) were rapidly eliminated after administration but able to distribute throughout the vagina and lower uterus, and capable of tackling mucus and penetrate the epithelial lining. Nanocarriers modified the PK of dapivirine, with higher drug levels being recovered from vaginal lavages and vaginal/lower uterine tissues as compared to a drug suspension. Systemic drug exposure was reduced when NPs were used. Also, NPs were shown safe upon administration for 14 days.Conclusions
Dapivirine-loaded PEO-PCL NPs were able to provide likely favorable genital drug levels, thus attesting the potential value of using this vaginal drug delivery nanosystem in the context of HIV prophylaxis. 相似文献55.
Subodh Verma MD Udi Fainberg MD Mansoor Husain MD Søren Rasmussen PhD Lars Rydén MD Maria Sejersten Ripa MD John B. Buse MD 《Diabetes, obesity & metabolism》2021,23(7):1677-1680
In the REWIND trial, dulaglutide reduced cardiovascular (CV) risk versus placebo in patients with type 2 diabetes in both the “established CV disease” (CVD) and “CV risk factor” subgroups. The SUSTAIN 6 and PIONEER 6 trials of semaglutide used different criteria for established CVD from those used in REWIND. The present post hoc analysis assessed the effect of semaglutide on major adverse CV events (MACE) in a pooled population of SUSTAIN 6 and PIONEER 6 patients, re-categorized into CV risk subgroups using the REWIND CVD criteria. In the pooled analysis (n = 6480), a lower percentage of patients were in the established CVD subgroup, when using the REWIND CVD criteria, compared with the original trial CVD criteria (66.5% vs. 83.8%, respectively). After re-categorization, the risk of MACE was significantly lower with semaglutide versus placebo in the established CVD subgroup (hazard ratio [HR] 0.74, 95% confidence interval [CI] 0.59, 0.92) and nonsignificantly lower in the CV risk factor subgroup (HR 0.84, 95% CI 0.55, 1.28) (P-interaction = 0.60). These results suggest that the CV effects of semaglutide may extend to patients with type 2 diabetes across the CV risk continuum. 相似文献
56.
Christopher Sainsbury MD Jingya Wang PhD Krishna Gokhale MSc Dionisio Acosta-Mena PhD Samir Dhalla MRPharmS Nathan Byne Joht Singh Chandan PhD Astha Anand BMBCh Jennifer Cooper MBBCh Kelvin Okoth MPH Anuradhaa Subramanian MSc Mansoor N. Bangash PhD Thomas Taverner PhD Wasim Hanif PhD Sandip Ghosh FRCP Parth Narendran PhD Kar K. Cheng PhD Tom Marshall PhD Georgios Gkoutos PhD Konstantinos Toulis PhD Neil Thomas PhD Abd Tahrani PhD Nicola J. Adderley PhD Shamil Haroon PhD Krishnarajah Nirantharakumar MD 《Diabetes, obesity & metabolism》2021,23(1):263-269
57.
58.
Objective: To determine the frequency of adrenal injuries in patients presenting with blunt abdomi- nal trauma by computed tomography (CT). Methods: During a 6 month period from January 1, 2011 to June 30, 2011, 82 emergency CT examinations were performed in the setting of major abdominal trauma and ret- rospectively reviewed for adrenal gland injuries. Results: A total of 7 patients were identified as having adrenal gland injuries (6 males and 1 female). Two patients had isolated adrenal gland injuries. In the other 5 patients with nonisolated injuries, injuries to the liver (1 case), spleen (1 case), retroperitoneum (2 cases) and mesentery (4 cases) were identified. Overall 24 cases with liver injuries (29 %), 11cases with splenic injuries (13%), 54 cases with mesenteric injuries (65%), 14 cases (17%) with retroperitoneal injuries and 9 cases with renal injuries were identified. Conclusion: Adrenal gland injury is identified in 7 patients (11.7%) out of a total of 82 patients who underwent CT after major abdominal trauma. Most of these cases were nonisolated injuries. Our experience indicates that adrenal injury resulting from trauma is more common than suggested by other reports. The rise in incidence of adrenal injuries could be attributed to the mode of injury. 相似文献
59.
Zhenyu Chang Hui Zhang Khalid Mehmood Min Luo Yali Zhao Fazul Nabi 《Toxin reviews》2019,38(2):115-120
We determine the effect of nano copper on visceral organs and contents of trace elements in organs and serum in weanling pigs. Our results showed that following supplementary concentration with 25, 50 and 200?mg/kg/day of nano copper, contents of copper shows trend of increasing in liver, kidney and intestinal; and ferrum shows gradually decreasing. The histopathological examination showed hemolysis, degeneration, nucleus pycnosis in liver, while renal tubular epithelial cell exfoliation and lymphocyte infiltration were found in kidney on supplementation of high concentration of nano-copper. Therefore, dietary supplementation of nano-copper 25?mg/kg b.wt could be a potential substitute for weaning piglets. 相似文献