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181.
Mansoor TA Shinde PB Luo X Hong J Lee CO Sim CJ Son BW Jung JH 《Journal of natural products》2007,70(9):1481-1486
Guided by the brine shrimp lethality assay, eight new cerebrosides (1-8) have been isolated from an extract of the marine sponge Haliclona (Reniera) sp. A novel feature of these cerebrosides was the presence of unprecedented amide-linked long-chain fatty acid moieties. The planar structures of the cerebrosides (1-8) were established by 1D and 2D NMR spectroscopic techniques, mass spectrometric analyses, and chemical degradation methods. The isolated compounds did not display cytotoxicity to a panel of five human solid tumor cell lines. 相似文献
182.
183.
Uzma Rasheed Mughal Rashad Mehmood Bakhat Ali Muhammad Safder Rasool Bakhsh Tareen 《Journal of Asian natural products research》2013,15(6):601-606
Spiraeamide (1), a new sphingolipid, has been isolated from the ethyl acetate-soluble fraction of the methanolic extract of the whole plant of Spiraea brahuica, along with marrubiin (2), 19-acetylmarrubenol (3), and 6-acetylmarruenol (4). Their structures were elucidated by 1H and 13C NMR spectra, and COSY, NOESY, HMQC, HMBC, EI-MS, and FAB-MS experiments. 相似文献
184.
Mansour Salesi Mansoor Karimifar Fereshteh Salimi Parvin Mahzouni 《Rheumatology international》2011,31(8):1093-1095
Idiopathic granulomatous mastitis is an inflammatory mass in the breast. Patients typically present with a firm breast mass,
often associated with inflammation of the overlying skin. Nipple retraction, peau d’orange-like changes, and axillary adenopathy
may be present. We describe a 23-year-old pregnant woman with arthritis, erythema nodosum, and mastitis. 相似文献
185.
Michiro Susa Arun K Iyer Keinosuke Ryu Francis J Hornicek Henry Mankin Mansoor M Amiji Zhenfeng Duan 《BMC cancer》2009,9(1):399
Background
Drug resistance is a primary hindrance for the efficiency of chemotherapy against osteosarcoma. Although chemotherapy has improved the prognosis of osteosarcoma patients dramatically after introduction of neo-adjuvant therapy in the early 1980's, the outcome has since reached plateau at approximately 70% for 5 year survival. The remaining 30% of the patients eventually develop resistance to multiple types of chemotherapy. In order to overcome both the dose-limiting side effects of conventional chemotherapeutic agents and the therapeutic failure incurred from multidrug resistant (MDR) tumor cells, we explored the possibility of loading doxorubicin onto biocompatible, lipid-modified dextran-based polymeric nanoparticles and evaluated the efficacy. 相似文献186.
First described in 1727, Horner syndrome occurs from injury to one of the three neurons in the oculo-sympathetic pathway.
Its presence can be confirmed with pharmacologic testing, traditionally including cocaine testing with hydroxyamphetamine
localization. More recently, apraclonidine testing has become a viable alternative in some practices. Concern has been raised
regarding the possibility of false-negative results with apraclonidine testing as well as the safety of its use in young children. 相似文献
187.
Zafar Iqbal Khan Ilker Ugulu Kafeel Ahmad Sumaira Yasmeen Ijaz Rasool Noorka Naunain Mehmood Muhammad Sher 《Bulletin of environmental contamination and toxicology》2018,101(6):787-795
This study focused on evaluating the metal and metalloid contamination and associated risks in the two vegetables crops, coriander (Coriandrum sativum) and spinach (Spinacia oleracea) treated with three water regimes, canal water, groundwater and municipal wastewater. These vegetables are widely consumed by people and are also used in traditional medicine for treating various disorders. Metal and metalloid accumulation (Zn, Pb, Se, Cu, As, Mo, Fe, Ni) was found higher in vegetables treated with wastewater. Wastewater treated soil had high pollution load index. Fe, Zn, As and Pb had higher values in water, soil and vegetables as compared to other studied metals. Overall, metal correlation for soil and vegetables was significant and positive except for Fe and Cu in spinach. The highest value for daily metal intake was estimated for Fe while Se had the lowest value for the same index. It was thus concluded that trace metal and metalloid accumulation was a major health concern for the public consuming these vegetables. 相似文献
188.
Chronic hepatitis B virus infection causes nearly all the deaths from this virus. As the initial infection occurs without symptoms and decades prior to the onset of cirrhosis and liver cancer, these consequences are rarely recognized as being caused by the virus. Consequently, its public health importance is under-recognized. Safe and effective vaccines have now been available for over 20 years. Concerns have been raised regarding the mercury preservative in vaccines leading to potential toxicity. But the evidence to date does not support any association of hepatitis B vaccine with serious adverse consequences. Protecting infants through immunization is the most effective control strategy. By 2005, over 80% of countries had implemented routine infant immunization. In countries with relatively low rates of hepatitis B virus infection, some have argued to defer immunization until later life. However, these arguments focus on the more visible acute infection. The possible future cost from a single infant infection argues for universal infant hepatitis B immunization--given the very high costs of treating its consequences (e.g., liver transplant) and the very low price of the vaccine. 相似文献
189.
Nishtar S Badar A Kamal MU Iqbal A Bajwa R Shah T Larik Z Karim F Mehmood Mu Jehangir H Azam SI Mirza YA Khan SA Qayyum A Aqeel F Bakir A Rahim E 《Promotion & education》2007,14(1):17-27
Mainstream preventive interventions often fail to reach poor populations with a high risk of cardiovascular diseases (CVDs) in Pakistan. A community-based CVD primary prevention project aimed at developing approaches to reduce risk factors in such populations was established by Heartfile in collaboration with the National Rural Support Program in the district of Lodhran. The project implemented a range of activities integrated with existing social and health service mechanisms during a three year intervention period 2000/01-03/04. These were targeted in 4 key settings: community health education, mass media interventions, training of health professionals and health education through Lady Health Workers. The project received support from the Department for International Development, U.K. At the community level, a pre-test-post-test quasi-experimental design was used for examining project outcomes related to the community component of the intervention. Pre and post-intervention (training) evaluations were conducted involving all health care providers in randomly selected workshops in order to determine baseline levels of knowledge and the impact of training on knowledge level. In order to assess practices of physician and non-physician health care providers patient interviews, with control comparisons were conducted at each health care facility. Significant positive changes were observed in knowledge levels at a community level in the district of intervention compared with baseline knowledge levels particularly in relation to a heart healthy diet, beneficial level of physical activity, the causes of high blood pressure and heart attack and the effects of high blood pressure and active and passive smoking on health. Significant changes in behaviors at a practice level were not shown in the district of intervention. However the project played a critical role in spurring national action for the prevention and control of non-communicable diseases and introducing sustainable public health interventions for poor communities in Pakistan. 相似文献
190.
Chee Khoon Lee PhD Michael L. Friedlander PhD Angelina Tjokrowidjaja MPH Jonathan A. Ledermann MD Robert L. Coleman MD Mansoor R. Mirza MD Ursula A. Matulonis MD Eric Pujade-Lauraine PhD Ralph Bloomfield MSc Sandra Goble MS Ping Wang PhD Rosalind M. Glasspool PhD Clare L. Scott PhD the Gynecologic Cancer Intergroup Meta-Analysis Committee 《Cancer》2021,127(14):2432-2441