全文获取类型
收费全文 | 5376篇 |
免费 | 262篇 |
国内免费 | 52篇 |
专业分类
耳鼻咽喉 | 56篇 |
儿科学 | 72篇 |
妇产科学 | 31篇 |
基础医学 | 581篇 |
口腔科学 | 154篇 |
临床医学 | 298篇 |
内科学 | 1287篇 |
皮肤病学 | 200篇 |
神经病学 | 508篇 |
特种医学 | 208篇 |
外科学 | 909篇 |
综合类 | 21篇 |
一般理论 | 1篇 |
预防医学 | 114篇 |
眼科学 | 227篇 |
药学 | 289篇 |
中国医学 | 6篇 |
肿瘤学 | 728篇 |
出版年
2024年 | 5篇 |
2023年 | 49篇 |
2022年 | 103篇 |
2021年 | 172篇 |
2020年 | 93篇 |
2019年 | 120篇 |
2018年 | 155篇 |
2017年 | 113篇 |
2016年 | 155篇 |
2015年 | 146篇 |
2014年 | 183篇 |
2013年 | 209篇 |
2012年 | 405篇 |
2011年 | 398篇 |
2010年 | 250篇 |
2009年 | 225篇 |
2008年 | 362篇 |
2007年 | 351篇 |
2006年 | 338篇 |
2005年 | 326篇 |
2004年 | 344篇 |
2003年 | 316篇 |
2002年 | 278篇 |
2001年 | 47篇 |
2000年 | 35篇 |
1999年 | 49篇 |
1998年 | 63篇 |
1997年 | 39篇 |
1996年 | 45篇 |
1995年 | 48篇 |
1994年 | 36篇 |
1993年 | 40篇 |
1992年 | 33篇 |
1991年 | 17篇 |
1990年 | 14篇 |
1989年 | 9篇 |
1988年 | 17篇 |
1987年 | 7篇 |
1986年 | 11篇 |
1985年 | 14篇 |
1984年 | 13篇 |
1983年 | 6篇 |
1982年 | 7篇 |
1981年 | 4篇 |
1980年 | 6篇 |
1978年 | 9篇 |
1977年 | 5篇 |
1975年 | 6篇 |
1973年 | 3篇 |
1971年 | 2篇 |
排序方式: 共有5690条查询结果,搜索用时 10 毫秒
111.
Hiroyoshi Adachi MD PhD Shunichiro Shinagawa MD PhD Kenjiro Komori MA Yasutaka Toyota MD PhD Takaaki Mori MD PhD Teruhisa Matsumoto MD PhD Naomi Sonobe MD PhD Tetsuo Kashibayashi MD PhD Tomohisa Ishikawa MD PhD Ryuji Fukuhara MD PhD Manabu Ikeda MD PhD 《Psychiatry and clinical neurosciences》2013,67(3):148-153
112.
Haruko Tanji Shingo Koyama Manabu Wada Toru Kawanami Keiji Kurita Gen Tamiya Naohiro Saito Kyoko Suzuki Takeo Kato Karen E. Anderson Ann L. Gruber-Baldini Paul S. Fishman Stephen G. Reich William J. Weiner Lisa M. Shulman 《Parkinsonism & related disorders》2013,19(6):628-633
BackgroundJapan and the United States (US) have different cultures of caregiving including differences in family structure and social programs that may influence caregiver strain. Differences in caregiver strain between regions in Japan and in the US have not been investigated in patient–spouse dyads in PD.ObjectivesTo compare caregiver strain in spouses of PD patients between Yamagata, Japan and Maryland, US. Correlations between caregiver strain and patient/spousal variables are also examined.MethodsIn Yamagata and Maryland, spouses of patients with PD completed questionnaires assessing caregiver strain. Patients and spouses completed scales assessing mental health, and medical co-morbidity. PD severity and disability were assessed with the Unified Parkinson's Disease Rating Scale and the Schwab and England Activities of Daily Living Scale. Results in the two regions were compared with Chi-square and Student's t-tests. Relationships between caregiver strain and patient/spousal variables were analyzed with univariate correlations and multivariate regression.Results178 Spouse–patient pairs were assessed. The level of caregiver strain in PD did not differ between Yamagata, Japan and Maryland, US despite differences in demographics and social support programs in the two regions. Yamagata spouses reported physical, time and financial constraints, while Maryland spouses reported more emotional distress. In both regions, spousal depression was a significant contributor to caregiver strain.ConclusionDifferent approaches to reduce caregiver strain will likely be necessary in Yamagata and Maryland since the contributing factors to caregiver strain are influenced by differences in culture and social supports in each country. 相似文献
113.
Noriko Azuma Tsukasa Okano Masanori Tamaoki Nobuyoshi Nakajima Noriko Takamura Yasushi Yokohata Junji Shindo Manabu Onuma 《Conservation Genetics Resources》2013,5(4):1001-1003
The large Japanese wood mouse (Apodemus speciosus) is common, but endemic to Japan, and its population structure was affected by habitat fragmentation because of urbanization. It suggested that the species might be one of the important models for the conservation of ecosystems and biodiversity affected by humans, including the effect of radioactive discharge caused by nuclear power plant accidents at Fukushima. We developed and characterized 25 novel polymorphic microsatellite markers from the next-generation sequencing data in an effort to provide an effective tool for genetic studies on this species. In 8 individuals from Aomori, Japan, the number of alleles and expected heterozygosities ranged from 5 to 13 and from 0.795 to 0.991, respectively, suggesting the availability of these markers for genetic studies in this species. 相似文献
114.
Katsushige Yamashiro M.D. Toshiya Shinohara M.D. Tomoko Mitsuhashi M.D. Takuya Sugimura C.T. Kiyomi Taira C.T. Manabu Azuma C.T. Dai Okuyama C.T. Manami Nakajima C.T. Hiroko Takeda M.D. Hiroaki Suzuki M.D. 《Diagnostic cytopathology》2013,41(1):47-52
We have built a database on the Internet managing z‐axis video for cytology (Zavic), and report on a new style of case discussion supported by the Zavic database. Z‐axis video for cytology is a movie file derived from the video recording of a microscopic field with changes in the focus. We used it for the case presentation of EUS‐FNA of pancreatic lesions on the Internet prior to a training workshop. The attendees were asked to observe the Zavic and to make diagnoses of 20 cases before the workshop. Fourteen attendees also observed lesions under a microscope on that day, and the results were compared with those of Zavic observation. The evaluation of the Zavic database (DB) was surveyed by a questionnaire. The average number of accurate diagnoses by 46 Zavic observers was 10.8. These accuracies for those who observed both the Zavic and glass slides were 11.57 and 11.43, respectively, for the videos and slides. Compared with Zavic observation alone, the diagnoses with glass slide observation were shifted to a correct diagnosis in two cases, but were shifted to an incorrect diagnosis in two cases. Approximately 60% of Zavic observers replied in the questionnaire that the movies on Zavic DB started to play within 3–4 seconds after clicking the play button. We successfully carried out the new style of case discussion supported by the Zavic DB. It was evaluated favorably by many attendees, who were psychologically still dependent on the glass slide observation. Diagn. Cytopathol. 2013. © 2011 Wiley Periodicals, Inc. 相似文献
115.
A 73-year-old woman was admitted to our hospital with anterior acute myocardial infarction due to subacute thrombosis after
coronary stenting with a zotarolimus-eluting stent (ZES), which is a newly developed drug-eluting stent that has been widely
used since May 2009 in Japan. Five days before, she underwent implantation with a ZES in the left anterior descending artery
due to stable angina pectoris. After stenting, the intravascular ultrasonography showed no malapposition from the proximal
to the distal edge of the stent. She received aspirin 100 mg/day and clopidogrel 75 mg/day from 2 weeks before the stent was
implanted. When we investigated the single nucleotide polymorphisms of CYP2C19 in this patient, both CYP2C19*2 and CYP2C19*3
were detected, and she was classified as a poor metabolizer. This report is the first to describe subacute stent thrombosis
following the implantation of a newly developed ZES in a Japanese patient, which may be related to clopidogrel resistance. 相似文献
116.
Fujishiro M Jung HY Goda K Hirasawa K Kakushima N Lee IL Morita Y Oda I Takeuchi M Yamamoto Y Zhou PH Uedo N 《Digestive endoscopy》2012,24(Z1):121-123
Endoscopic submucosal dissection (ESD) was invented in Japan and is now permeating into the rest of the world. Therefore, it is necessary to elucidate the desirable ESD training by knowing the current status of ESD training in Japan. After this, we mainly discussed the following three topics: (i) requirements for preceptees to start ESD training; (ii) requirements for competent endoscopists in ESD; and (iii) requirements for preceptors in the first half of the upper gastrointestinal tract session at the Endoscopic Forum Japan 2011. Additionally, we discussed what Japanese endoscopists can do for further permeation of ESD outside Japan, especially in Asia in the second half. The session was wrapped up by the conclusions that it was absolutely necessary to establish official training courses authorized by the Japan Gastroenterological Endoscopy Society with certification for trainees and trainers and our Japanese endoscopists had a responsibility to spread ESD safely and reliably by collaborating with enthusiastic endoscopists in each country which have different backgrounds in terms of incidences and screening systems of target diseases, accessibility to endoscopy, medical economics, national characters, and so on. 相似文献
117.
118.
119.
Yoshiyuki Yukawa Manabu Muto Yusuke Amanuma Yasumasa Ezoe Yoko Mashimo Kimiko Hori Takahiro Horimatsu Shuko Morita Shin’ichi Miyamoto Sachiko Minamiguchi Tsutomu Chiba 《Esophagus》2012,9(4):203-209
Background
Dysplastic squamous epithelium is a precancerous lesion for squamous cell carcinoma. It is often present in the esophagus and head and neck region, and can be visualized as a Lugol-voiding lesion (LVL) by iodine chromoendoscopy. However, effective treatment for such dysplastic epithelia has not yet been developed.Methods
Between March 2008 and July 2011, 40 consecutive patients with advanced esophageal squamous cell carcinoma were treated by two cycles of neoadjuvant chemotherapy (NAC) (5-fluorouracil, 800?mg/m2, d 1?C5; cisplatin, 80?mg/m2, d 1: q 21?days) at Kyoto University Hospital, and received iodine chromoendoscopy both before and after NAC. Iodine chromoendoscopy findings were divided into 4 groups: group?A, absence of LVLs; group?B, several (??10/one endoscopic view) small (??5?mm) LVLs; group?C, many (??10/one endoscopic view) small (??5?mm) LVLs; group?D, numerous irregular-shaped multiform LVLs. Group?C and D are defined as multiple LVLs. Endoscopic changes of LVLs before and after NAC were investigated retrospectively.Results
Before NAC, 6, 12, 9, and 13 cases were classified in group?A, B, C, and D, respectively. All cases in group?A before NAC remained in group?A after NAC. Multiple LVLs (group?C and D) were significantly improved in 17 of 22 patients (77.3?%), while several small LVLs (group?B) were improved in only 4 of 12 cases (33.3?%) (p?=?0.025 by Fisher??s exact test).Conclusions
Multiple dysplastic lesions tended to improve by chemotherapy. In contrast, there was little change in the mucosa with fewer dysplastic lesions after chemotherapy. These data show that chemotherapy has the potential to eliminate precancerous lesions. 相似文献120.
Manabu Onishi Kazuhiko Kurozumi Tomotsugu Ichikawa Isao Date 《Neurologia medico-chirurgica》2013,53(11):755-763
Despite advances in surgical and medical therapy, glioblastoma multiforme (GBM) remains a fatal disease. There has been no significant increase in survival for patients with this disease over the last 20 years. Tumor vasculature formation and glioma cell invasion along the white matter tracts both play a pivotal role in glioma development. Angiogenesis and invasion are the major factors believed to be responsible for treatment resistance in tumors, and a better understanding of the glioma invasion and angiogenesis mechanisms will lead to the development of potential new treatments. In this review, we focus on the molecular characteristics of angiogenesis and invasion in human malignant glioma. We discuss bevacizumab and cilengitide, which are used to inhibit angiogenesis in GBM. 相似文献