全文获取类型
收费全文 | 799篇 |
免费 | 28篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 15篇 |
儿科学 | 35篇 |
妇产科学 | 25篇 |
基础医学 | 130篇 |
口腔科学 | 17篇 |
临床医学 | 74篇 |
内科学 | 214篇 |
皮肤病学 | 12篇 |
神经病学 | 40篇 |
特种医学 | 18篇 |
外科学 | 53篇 |
综合类 | 2篇 |
预防医学 | 155篇 |
眼科学 | 3篇 |
药学 | 13篇 |
中国医学 | 3篇 |
肿瘤学 | 23篇 |
出版年
2023年 | 6篇 |
2022年 | 25篇 |
2021年 | 22篇 |
2020年 | 12篇 |
2019年 | 28篇 |
2018年 | 20篇 |
2017年 | 13篇 |
2016年 | 33篇 |
2015年 | 17篇 |
2014年 | 35篇 |
2013年 | 40篇 |
2012年 | 46篇 |
2011年 | 70篇 |
2010年 | 36篇 |
2009年 | 27篇 |
2008年 | 40篇 |
2007年 | 41篇 |
2006年 | 37篇 |
2005年 | 43篇 |
2004年 | 37篇 |
2003年 | 36篇 |
2002年 | 22篇 |
2001年 | 17篇 |
2000年 | 22篇 |
1999年 | 17篇 |
1998年 | 3篇 |
1997年 | 5篇 |
1996年 | 5篇 |
1995年 | 4篇 |
1992年 | 4篇 |
1991年 | 9篇 |
1989年 | 2篇 |
1988年 | 6篇 |
1987年 | 3篇 |
1986年 | 4篇 |
1985年 | 3篇 |
1984年 | 2篇 |
1983年 | 11篇 |
1982年 | 2篇 |
1980年 | 2篇 |
1979年 | 2篇 |
1977年 | 4篇 |
1974年 | 1篇 |
1973年 | 3篇 |
1972年 | 3篇 |
1971年 | 3篇 |
1969年 | 1篇 |
1968年 | 1篇 |
1967年 | 2篇 |
1965年 | 3篇 |
排序方式: 共有832条查询结果,搜索用时 15 毫秒
11.
Niang A Diallo S Ka MM Pouye A Diop S Ndongo S Diop TM 《La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne》2004,25(11):826-828
INTRODUCTION: Macrophage activation syndrome (MAS) is a severe complication of chronic rheumatic diseases, particularly juvenile rheumatoid arthritis. However, MAS is rarely described in adult rheumatoid polyarthritis. EXEGESE: We report a case of MAS complicating a seropositive rheumatoid polyarthritis after 20 years of evolution. Pancytopenia with fever, renal failure and hepatic dysfunction revealed the disease that was confirmed by multiple macrophages and monocytes invading the bone marrow specimen. CONCLUSION: Outcome has been spectacular under corticosteroids. 相似文献
12.
13.
14.
Holly M. Burke Monique P. Mueller Catherine Packer Brian Perry Leonard Bufumbo Daouda Mbengue Bocar Mamadou Daff Anthony Mbonye 《Contraception》2014
Background
Sayana® Press (SP), a subcutaneous formulation of depot medroxyprogesterone acetate (DMPA) in Uniject™, has potential to be a valuable innovation in family planning (FP) because it may overcome logistic and safety challenges in delivering intramuscular DMPA (DMPA IM). However, SP's acceptability is unknown. We measured acceptability of SP among clinic-based providers (Senegal only) and community health workers.Study design
This open-label observational study was conducted in clinics in three districts in Senegal and community-based services in two districts in Uganda. Providers administered SP to clients seeking reinjection of DMPA IM. We conducted in-depth interviews with 86 providers (52 in Senegal, 34 in Uganda) to assess their experiences providing SP to clients.Results
Almost all providers (84/86; 98%) preferred SP over DMPA IM. The main reason Uganda providers preferred SP was the prefilled/all-in-one design made preparation and administration easier and faster. Some providers thought the SP all-in-one feature may decrease stock outs (DMPA IM requires syringe and vial). Providers also felt clients preferred the shorter SP needle because it is less intimidating and less painful. Similarly, the main reasons Senegal providers preferred SP were its characteristics (prefilled/all-in-one) and client preference (especially less pain). They also saw a potential to increase access to FP, especially through community-based distribution. Providers from both countries reported SP introduction would be enhanced through client counseling and community engagement. Providers also said SP must be accessible, affordable and in stock.Conclusion
Almost all providers preferred SP over DMPA IM. Provider recommendations should be considered during SP introduction planning.Implications
We found that SP was acceptable to both clinic-based FP providers and community health workers. Providers' positive attitudes towards SP may facilitate introduction and uptake of this method. 相似文献15.
Helen E.D. Burchett Sandra Mounier-Jack Sergio Torres-Rueda Ulla K. Griffiths Pierre Ongolo-Zogo Stephen Rulisa Jean-Marie Edengue Enrique Chavez Yayehirad Kitaw Mitike Molla Mamadou Konate Lawrence Gelmon Washington Onyango-Ouma Mylene Lagarde Anne Mills 《Vaccine》2014
Objective
We aimed to explore the impacts of new vaccine introductions on immunization programmes and health systems in low- and middle-income countries.Methods
We conducted case studies of seven vaccine introductions in six countries (Cameroon, PCV; Ethiopia, PCV; Guatemala, rotavirus; Kenya, PCV; Mali, Meningitis A; Mali, PCV; Rwanda, HPV). Interviews were conducted with 261 national, regional and district key informants and questionnaires were completed with staff from 196 health facilities. Routine data from districts and health facilities were gathered on vaccination and antenatal service use. Data collection and analysis were structured around the World Health Organisation health system building blocks.Findings
The new vaccines were viewed positively and seemed to integrate well into existing health systems. The introductions were found to have had no impact on many elements within the building blocks framework. Despite many key informants and facility respondents perceiving that the new vaccine introductions had increased coverage of other vaccines, the routine data showed no change. Positive effects perceived included enhanced credibility of the immunisation programme and strengthened health workers’ skills through training. Negative effects reported included an increase in workload and stock outs of the new vaccine, which created a perception in the community that all vaccines were out of stock in a facility. Most effects were found within the vaccination programmes; very few were reported on the broader health systems. Effects were primarily reported to be temporary, around the time of introduction only.Conclusion
Although the new vaccine introductions were viewed as intrinsically positive, on the whole there was no evidence that they had any major impact, positive or negative, on the broader health systems. 相似文献16.
Katherine Ember Franois Daoust Myriam Mahfoud Frdrick Dallaire Esmat Zamani Ahmad Trang Tran Arthur Plante Mame-Kany Diop Tien Nguyen Amlie St-Georges-Robillard Nassim Ksantini Julie Lanthier Antoine Filiatrault Guillaume Sheehy Gabriel Beaudoin Caroline Quach Dominique Trudel Frdric Leblond 《Journal of biomedical optics》2022,27(2)
17.
Mory Keita Mahamoud Sama Cherif Billy Sivahera Samuel T. Boland Freddy Banza-Mutoka Mamadou Kourouma Alseny Modet Camara Youssouf Sidibe Jean Paul Kimenyi Lamine Diassy Angelo Loua Ibrahima Sory Fofana Youba Kandako Dobo Onivogui Enogo Koivogui Tamba Jacques Millimono Fode Diakite Mamadou Balde Bienvenu Houndjo Ngoy Nsenga Ambrose Talisuna Alexandre Delamou Olivia Keiser Georges Alfred Ki-Zerbo Abdou Salam Gueye 《The American journal of tropical medicine and hygiene》2022,106(4):1094
18.
Dawid Maciorowski Cheikh Diop Urja Bhatt Reynette Estelien Dan Li Ruchi Chauhan Luk H. Vandenberghe Nerea Zabaleta 《Viruses》2022,14(4)
The SARS-CoV-2 pandemic has had a disastrous impact on global health. Although some vaccine candidates have been effective in combating SARS-CoV-2, logistical, economical, and sociological aspects still limit vaccine access globally. Recently, we reported on two room-temperature stable AAV-based COVID-19 vaccines that induced potent and protective immunogenicity following a single injection in murine and primate models. Obesity and old age are associated with increased mortality in COVID-19, as well as reduced immunogenicity and efficacy of vaccines. Here, we investigated the effectiveness of the AAVCOVID vaccine candidates in murine models of obesity and aging. Results demonstrate that obesity did not significantly alter the immunogenicity of either vaccine candidate. In aged mice, vaccine immunogenicity was impaired. These results suggest that AAV-based vaccines may have limitations in older populations and may be equally applicable in obese and non-obese populations. 相似文献
19.