全文获取类型
收费全文 | 822篇 |
免费 | 40篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 18篇 |
妇产科学 | 30篇 |
基础医学 | 80篇 |
口腔科学 | 3篇 |
临床医学 | 31篇 |
内科学 | 297篇 |
皮肤病学 | 5篇 |
神经病学 | 18篇 |
特种医学 | 40篇 |
外科学 | 188篇 |
综合类 | 13篇 |
预防医学 | 46篇 |
眼科学 | 7篇 |
药学 | 43篇 |
肿瘤学 | 43篇 |
出版年
2022年 | 10篇 |
2021年 | 19篇 |
2020年 | 8篇 |
2019年 | 14篇 |
2018年 | 24篇 |
2017年 | 16篇 |
2016年 | 12篇 |
2015年 | 11篇 |
2014年 | 21篇 |
2013年 | 26篇 |
2012年 | 29篇 |
2011年 | 35篇 |
2010年 | 32篇 |
2009年 | 30篇 |
2008年 | 39篇 |
2007年 | 41篇 |
2006年 | 37篇 |
2005年 | 42篇 |
2004年 | 34篇 |
2003年 | 37篇 |
2002年 | 44篇 |
2001年 | 9篇 |
2000年 | 8篇 |
1999年 | 14篇 |
1998年 | 11篇 |
1997年 | 9篇 |
1996年 | 5篇 |
1995年 | 7篇 |
1992年 | 9篇 |
1991年 | 12篇 |
1990年 | 17篇 |
1989年 | 15篇 |
1988年 | 12篇 |
1987年 | 13篇 |
1985年 | 10篇 |
1984年 | 17篇 |
1983年 | 15篇 |
1982年 | 8篇 |
1981年 | 6篇 |
1979年 | 6篇 |
1978年 | 10篇 |
1975年 | 7篇 |
1973年 | 8篇 |
1972年 | 5篇 |
1971年 | 5篇 |
1970年 | 10篇 |
1969年 | 6篇 |
1967年 | 5篇 |
1966年 | 5篇 |
1935年 | 5篇 |
排序方式: 共有865条查询结果,搜索用时 734 毫秒
81.
82.
Background
Opioid analgesics have proven efficacy in the short-term management of chronic cancer pain, but data on their long-term use is more limited. OROS? hydromorphone is a controlled-release formulation of oral hydromorphone that may be particularly well suited to long-term management of chronic cancer pain because it provides stable plasma concentrations and consistent analgesia with convenient once-daily dosing. The objective of this study (DO-118X) was to characterise the pain control achieved with long-term repeated dosing of OROS? hydromorphone in patients with chronic cancer pain. 相似文献83.
Sanjay Jaju Samir Al-Adawi Hilal Al-Kharusi Magdi Morsi Asya Al-Riyami 《Child and adolescent psychiatry and mental health》2009,3(1):29-11
Background
There is a dearth of studies exploring the magnitude of mental disorders amongst adolescents and youths in the Arab world. To our knowledge, this phase 2 survey in Oman is the first nationally representative school-based study to determine the prevalence of DSM-IV mental disorders (lifetime and over the preceding 12 months), their age-of-onset distributions and determine their severity over the past 12 months using the World Mental Health-Composite International Diagnostic Interview, the WMH-CIDI, used for international comparison. 相似文献84.
Asya A Al Riyami Samir H Al Adawi Hilal A Al Kharusi Magdi M Morsi Sanjay S Jaju 《International journal of mental health systems》2009,3(1):22-11
Background
Recent corpus of research suggests that psychiatric disorders amongst adolescents and youths are an emerging global challenge, but there is paucity of studies exploring health services utilization by this age group in Arab region. 相似文献85.
86.
Although chronic pain and depression commonly co-occur, causal relationships have yet to be established. A reciprocal relationship, with depression increasing pain and vice versa, is most frequently suggested, but experimental evidence is needed to validate such a view. The most straightforward approach would be a demonstration that increasing or decreasing depressed mood predictably modifies pain responses. The current experiment tested whether experimentally induced depressed and happy mood have differential effects on pain ratings and tolerance in 55 patients suffering from chronic back pain. Participants were randomly assigned to depressed, neutral (control) or elated mood induction conditions. They completed a physically passive baseline task prior to receiving mood induction, then a clinically relevant physically active task (holding a heavy bag) to elicit pain responses and tolerance. Measures were taken immediately after the baseline task and immediately after the mood induction to assess the changes in mood, pain ratings and tolerance before and after the experimental manipulation. Results indicate that the induction of depressed mood resulted in significantly higher pain ratings at rest and lower pain tolerance, whilst induced happy mood resulted in significantly lower pain ratings at rest and greater pain tolerance. Correlations between changes in mood on the one hand and changes in pain response and pain tolerance on the other hand were consistent with these findings. It is concluded that, in chronic back pain patients, experimentally induced negative mood increases self-reported pain and decreases tolerance for a pain-relevant task, with positive mood having the opposite effect. 相似文献
87.
88.
Takemoto SK Arns W Bunnapradist S Garrison LP Guirado L Kalo Z Oniscu G Opelz G Scolari MP Stefoni S Yaqoob M Brennan DC 《Transplantation》2008,86(1):18-25
Transplantation offers a unique opportunity to demonstrate the complementary roles of randomized controlled trials and outcome research. The surgery and collaboration necessary for the transplant procedure makes randomization and blinding difficult. Because essentially every recipient is included in a transplant registry, sampling bias is minimized. Regulatory agencies generally do not consider outcomes research when assessing efficacy of new drugs or medical interventions. This workgroup summary examines the suitability of outcomes research to complement results of randomized controlled trials and related issues: efficacy versus effectiveness, internal versus external validity, data types, limitations, and analysis methodologies. Many advances in outcomes research have been pioneered in transplantation. A case is made for regulatory and reimbursement authorities to use outcomes research when making efficacy, effectiveness, and coverage decisions in transplantation. 相似文献
89.
There is a general perception that patients with polycystic kidney disease on peritoneal dialysis have poor long-term technique survival. In order to test this opinion, we performed a retrospective analysis comparing results of 56 consecutive patients with polycystic kidney disease to 56 non-diabetic patients with bilateral small kidneys. The patient groups were all initiated on peritoneal dialysis over a 12 year period and matched for age, gender and years of end stage renal failure. After a mean follow-up period of 37 months the two groups were statistically indistinguishable in terms of mortality, kidney transplantation-censored technique survival, median death-censored technique survival, the number of patients switched permanently to hemodialysis due to technique failure and the rate of peritonitis. On Cox regression (multivariate) analysis, only the baseline serum albumin level was a significant and independent risk factor of death-censored technique failure. Our study found no difference in long term outcome of peritoneal dialysis therapy in patients with polycystic kidney disease compared to a non-diabetic matched control group. 相似文献
90.
The reinforced laryngeal mask airway for dento-alveolar surgery 总被引:3,自引:0,他引:3
Quinn A. C.; Samaan A.; McAteer E. M.; Moss E.; Vucevic M. 《British journal of anaesthesia》1996,77(2):185-188
We have evaluated the reinforced laryngeal mask airway (LMA) for use during
dento-alveolar surgery in 100 ASA I and II day-case patients allocated
randomly to receive either a nasotracheal tube or reinforced LMA. We
recorded ease of airway insertion, airway complications, quality of
recovery and replies to a 24-h postoperative questionnaire. In addition, a
fibreoptic assessment was made of laryngotracheal soiling, and the effect
of head movement and the position of the reinforced LMA. There were no
significant differences in difficulty in airway positioning or
perioperative oxygen desaturation. Nineteen patients in the nasotracheal
tube group had epistaxis (P = 0.001) and laryngotracheal soiling occurred
in three of these patients. Two reinforced LMA were dislodged on moving
into the operating theatre and in a further five patients in this group
there was partial airway obstruction (compared with none in the
nasotracheal tube group; P = 0.018) which was caused by downward pressure
on the mandible by the surgeon. There were no differences in postoperative
complications. No surgeon reported poor access to the operating field.
Overall the reinforced LMA provided satisfactory conditions for this
surgery but vigilance of the airway was required, especially at the time of
extraction.
相似文献