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排序方式: 共有635条查询结果,搜索用时 15 毫秒
21.
Jonathan N. Johnson MD FACC Cindy S. Barrett MD Wayne H. Franklin MD FACC Eric M. Graham MD FACC Nancy J. Halnon MD Brandy A. Hattendorf MD FACC Catherine D. Krawczeski MD FACC James J. McGovern MD FACC Matthew J. O'Connor MD Amy H. Schultz MD MSCE FACC Jeffrey M. Vinocur MD Devyani Chowdhury MD FACC Jeffrey B. Anderson MD MPH FACC 《Congenital heart disease》2017,12(6):756-761
22.
D. Scot Malay DPM MSCE FACFAS David J. Margolis MD PhD Ole J. Hoffstad MA Scarlett Bellamy ScD 《The Journal of foot and ankle surgery》2006,45(6):366-374
The primary goal of this retrospective cohort study was to determine the incidence of failure to heal after lower extremity amputation for the treatment of diabetic neuropathic foot ulcer, and the secondary goal was to identify risk factors associated with the outcome. We evaluated 1775 patients who underwent amputation for the treatment of 5314 neuropathic foot ulcers, and who were treated in a network of wound care centers. We calculated the incidence of failure to heal after the initial amputation, and used generalized estimation equations and generalized linear latent and mixed model regression to evaluate the association of failure to heal by the 20th week of care. The unadjusted incidence of failure to heal was 34.01%, and male sex, number of wounds, wound grade, and adjunct therapy were all significantly associated with failure to heal. With the exception of wound grade, the associations were not significantly affected by the treating wound care center, and a sensitivity analysis showed the results to be resistant to the theoretical influence of an unmeasured potential confounder. These findings should be useful to clinicians treating diabetic neuropathic foot ulcers, and should aid surgeons in the determination of the most appropriate level for lower extremity amputation. 相似文献
23.
Background: Obesity and anovulation are common medical problems in the United States. Anovulation in obese patients primarily
manifests with irregular, sporadic or absent menstrual bleeding. Weight loss of at least 5% has been shown to reverse obesity-related
anovulation. The aim of this study was to assess the impact of bariatric surgery on infertility in morbidly obese women and
to identify factors associated with return of normal menses following bariatric surgery. Methods: A survey of patients was
collected from the bariatric surgery data-base at the Hospital of the University of Pennsylvania. 410 women under the age
of 40 were sent questionnaires. 195 patients completed the questionnaire, and 29 patients had incorrect addresses without
a forwarding address, resulting in a 51.2% response rate. Patients who reported menstrual cycle lengths >35 days were considered
abnormal. 92 of the 195 responders were considered anovulatory preoperatively, based on menstrual history. Results: There
was no significant difference in postoperative BMI, BMI decrease or age at surgery between the survey responders and non-responders.
There was a significant difference between these 2 groups in time since surgery (P=.01). Both groups had a decrease in BMI of >18 kg/m2. The mean menstrual cycle length preoperatively among those categorized as ovulatory and anovulatory was 27.3 and 127.5 days,
respectively. Of the 98 patients who were anovulatory preoperatively, 70 patients (71.4%) regained normal menstrual cycles
after surgery. Those patients who regained ovulation had greater weight loss than those who remained anovulatory (61.4 kg
vs 49.9 kg, P=0.02). Conclusions: Anovulation resulting in abnormal menses is a common problem in morbidly obese premenopausal women. The
menstrual cycle disorders may completely resolve after bariatric surgery. Thus, infertility due to anovulation among morbidly
obese women could potentially be viewed as an additional indication for bariatric surgery. 相似文献
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Jane L. Givens MD MSCE Richard N. Jones ScD Sharon K. Inouye MD MPH 《Journal of the American Geriatrics Society》2009,57(8):1347-1353
OBJECTIVES: To measure the prevalence, predictors, and posthospitalization outcomes associated with the overlap syndrome of coexisting depression and incident delirium in older hospitalized patients.
DESIGN: Secondary analysis of prospective cohort data from the control group of the Delirium Prevention Trial.
SETTING: General medical service of an academic medical center. Follow-up interviews at 1 month and 1 year post-hospital discharge.
PARTICIPANTS: Four hundred fifty-nine patients aged 70 and older who were not delirious at hospital admission.
MEASUREMENTS: Depressive symptoms assessed at hospital admission using the 15-item Geriatric Depression Scale (cutoff score of 6 used to define depression), daily assessments of incident delirium from admission to discharge using the Confusion Assessment Method, activities of daily living at admission and 1 month postdischarge, and new nursing home placement and mortality determined at 1 year.
RESULTS: Of 459 participants, 23 (5.0%) had the overlap syndrome, 39 (8.5%) delirium alone, 121 (26.3%) depression alone, and 276 (60.1%) neither condition. In adjusted analysis, patients with the overlap syndrome had higher odds of new nursing home placement or death at 1 year (adjusted odds ratio (AOR)=5.38, 95% confidence interval (CI)=1.57–18.38) and 1-month functional decline (AOR=3.30, 95% CI=1.14–9.56) than patients with neither condition.
CONCLUSION: The overlap syndrome of depression and delirium is associated with significant risk of functional decline, institutionalization, and death. Efforts to identify, prevent, and treat this condition may reduce the risk of adverse outcomes in older hospitalized patients. 相似文献
DESIGN: Secondary analysis of prospective cohort data from the control group of the Delirium Prevention Trial.
SETTING: General medical service of an academic medical center. Follow-up interviews at 1 month and 1 year post-hospital discharge.
PARTICIPANTS: Four hundred fifty-nine patients aged 70 and older who were not delirious at hospital admission.
MEASUREMENTS: Depressive symptoms assessed at hospital admission using the 15-item Geriatric Depression Scale (cutoff score of 6 used to define depression), daily assessments of incident delirium from admission to discharge using the Confusion Assessment Method, activities of daily living at admission and 1 month postdischarge, and new nursing home placement and mortality determined at 1 year.
RESULTS: Of 459 participants, 23 (5.0%) had the overlap syndrome, 39 (8.5%) delirium alone, 121 (26.3%) depression alone, and 276 (60.1%) neither condition. In adjusted analysis, patients with the overlap syndrome had higher odds of new nursing home placement or death at 1 year (adjusted odds ratio (AOR)=5.38, 95% confidence interval (CI)=1.57–18.38) and 1-month functional decline (AOR=3.30, 95% CI=1.14–9.56) than patients with neither condition.
CONCLUSION: The overlap syndrome of depression and delirium is associated with significant risk of functional decline, institutionalization, and death. Efforts to identify, prevent, and treat this condition may reduce the risk of adverse outcomes in older hospitalized patients. 相似文献
29.
Jane L Givens MD MSCE Maureen Frederick BA Leanne Silverman BA Stacy Anderson BA Joanna Senville Margery Silver EdD Paola Sebastiani PhD Dellara F Terry MD MPH Paul T. Costa PhD Thomas T. Perls MD MPH 《Journal of the American Geriatrics Society》2009,57(4):683-685
OBJECTIVES: To determine whether the offspring of centenarians have personality characteristics that are distinct from the general population.
DESIGN: Case-control.
SETTING: Nationwide U.S. sample.
PARTICIPANTS: Unrelated offspring of centenarians (n=246, mean age 75) were compared with published norms.
MEASUREMENTS: Using the NEO-Five-Factor Inventory (NEO-FFI) questionnaire, measures of the personality traits neuroticism, extraversion, openness, agreeableness, and conscientiousness were obtained. T-scores and percentiles were calculated according to sex and used to interpret the results.
RESULTS: Male and female offspring of centenarians scored in the low range of published norms for neuroticism and in the high range for extraversion. The women also scored comparatively high in agreeableness. Otherwise, both sexes scored within normal range for conscientiousness and openness, and the men scored within normal range for agreeableness.
CONCLUSION: Specific personality traits may be important to the relative successful aging demonstrated by the offspring of centenarians. Similarities across four of the five domains between male and female offspring is noteworthy and may relate to their successful aging. Measures of personality are an important phenotype to include in studies that assess genetic and environmental influences of longevity and successful aging. 相似文献
DESIGN: Case-control.
SETTING: Nationwide U.S. sample.
PARTICIPANTS: Unrelated offspring of centenarians (n=246, mean age 75) were compared with published norms.
MEASUREMENTS: Using the NEO-Five-Factor Inventory (NEO-FFI) questionnaire, measures of the personality traits neuroticism, extraversion, openness, agreeableness, and conscientiousness were obtained. T-scores and percentiles were calculated according to sex and used to interpret the results.
RESULTS: Male and female offspring of centenarians scored in the low range of published norms for neuroticism and in the high range for extraversion. The women also scored comparatively high in agreeableness. Otherwise, both sexes scored within normal range for conscientiousness and openness, and the men scored within normal range for agreeableness.
CONCLUSION: Specific personality traits may be important to the relative successful aging demonstrated by the offspring of centenarians. Similarities across four of the five domains between male and female offspring is noteworthy and may relate to their successful aging. Measures of personality are an important phenotype to include in studies that assess genetic and environmental influences of longevity and successful aging. 相似文献
30.
Risk factors and comorbidities associated with obesity in children and adolescents after the arterial switch operation and Ross procedure 总被引:1,自引:0,他引:1