首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   2818846篇
  免费   204388篇
  国内免费   9817篇
耳鼻咽喉   37953篇
儿科学   90851篇
妇产科学   78005篇
基础医学   396161篇
口腔科学   77329篇
临床医学   254660篇
内科学   560829篇
皮肤病学   67701篇
神经病学   230633篇
特种医学   108009篇
外国民族医学   791篇
外科学   424238篇
综合类   57996篇
现状与发展   6篇
一般理论   1028篇
预防医学   207555篇
眼科学   63589篇
药学   207736篇
  10篇
中国医学   7010篇
肿瘤学   160961篇
  2021年   22164篇
  2019年   22814篇
  2018年   32492篇
  2017年   24970篇
  2016年   28760篇
  2015年   32372篇
  2014年   44572篇
  2013年   65720篇
  2012年   87480篇
  2011年   91927篇
  2010年   55570篇
  2009年   53226篇
  2008年   85645篇
  2007年   91092篇
  2006年   92442篇
  2005年   88172篇
  2004年   84805篇
  2003年   81813篇
  2002年   78840篇
  2001年   143198篇
  2000年   146350篇
  1999年   123220篇
  1998年   34648篇
  1997年   30574篇
  1996年   30335篇
  1995年   29334篇
  1994年   26874篇
  1993年   25054篇
  1992年   94020篇
  1991年   89939篇
  1990年   86793篇
  1989年   83949篇
  1988年   76779篇
  1987年   75008篇
  1986年   70090篇
  1985年   66639篇
  1984年   49128篇
  1983年   41500篇
  1982年   24184篇
  1981年   21456篇
  1979年   42530篇
  1978年   29621篇
  1977年   25265篇
  1976年   23050篇
  1975年   24654篇
  1974年   28917篇
  1973年   27395篇
  1972年   25767篇
  1971年   23972篇
  1970年   22030篇
排序方式: 共有10000条查询结果,搜索用时 386 毫秒
11.
Collagens are the most abundant proteins in the extracellular matrix. They provide a framework to build organs and tissues and give structural support to make them resistant to mechanical load and forces. Several intra‐ and extracellular modifications are needed to make functional collagen molecules, intracellular post‐translational modifications of proline and lysine residues having key roles in this. In this article, we provide a review on the enzymes responsible for the proline and lysine modifications, that is collagen prolyl 4‐hydroxylases, 3‐hydroxylases and lysyl hydroxylases, and discuss their biological functions and involvement in diseases.  相似文献   
12.
Anaplastic thyroid carcinoma (ATC) is an aggressive thyroid malignancy with high mortality rate. This malignancy arises in thyroid follicular cells either denovo or with an associated differentiated thyroid carcinoma component. Clinically, it usually presents as a rapidly enlarging mass, pain and locally compressive symptoms. Histopathologic variability and heterogeneity often pose diagnostic challenges, especially in scant and paucicellular specimens. This article describes the clinical, histopathologic and molecular features of ATC and also addresses the associated diagnostic limitations and challenges.  相似文献   
13.
Bone mineral density (BMD) is a highly heritable predictor of osteoporotic fracture. GWAS have identified hundreds of loci influencing BMD, but few have been functionally analyzed. In this study, we show that SNPs within a BMD locus on chromosome 14q32.32 alter splicing and expression of PAR-1a/microtubule affinity regulating kinase 3 (MARK3), a conserved serine/threonine kinase known to regulate bioenergetics, cell division, and polarity. Mice lacking Mark3 either globally or selectively in osteoblasts have increased bone mass at maturity. RNA profiling from Mark3-deficient osteoblasts suggested changes in the expression of components of the Notch signaling pathway. Mark3-deficient osteoblasts exhibited greater matrix mineralization compared with controls that was accompanied by reduced Jag1/Hes1 expression and diminished downstream JNK signaling. Overexpression of Jag1 in Mark3-deficient osteoblasts both in vitro and in vivo normalized mineralization capacity and bone mass, respectively. Together, these findings reveal a mechanism whereby genetically regulated alterations in Mark3 expression perturb cell signaling in osteoblasts to influence bone mass.  相似文献   
14.
15.
16.
Immunoglobulin light chain amyloidosis (AL) commonly presents with nephrotic range proteinuria, heart failure with preserved ejection fraction, nondiabetic peripheral neuropathy, unexplained hepatomegaly or diarrhea, and should be considered in patients presenting with these symptoms. More importantly, patients being monitored for smoldering multiple myeloma and a monoclonal gammopathy of undetermined significance (MGUS) are at risk for developing AL amyloidosis. MGUS and myeloma patients that have atypical features, including unexplained weight loss; lower extremity edema, early satiety, and dyspnea on exertion should be considered at risk for light chain amyloidosis. Overlooking the diagnosis of light chain amyloidosis leading to therapy delay is common, and it represents an error of diagnostic consideration. Herein we provide a review of established and investigational treatments for patients with AL amyloidosis and provide algorithms for workup and management of these patients.Subject terms: Myeloma, Chemotherapy  相似文献   
17.
18.
19.
20.
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号