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91.
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Mohamed Magdy Ibrahim MD Jennifer Bond PhD Andrew Bergeron BA Kyle J. Miller BA Tosan Ehanire BA Carlos Quiles MD Elizabeth R. Lorden MS Manuel A. Medina MD Mark Fisher MD Bruce Klitzman PhD M. Angelica Selim MD Kam W. Leong PhD Howard Levinson MD 《Wound repair and regeneration》2014,22(6):755-764
Hypertrophic scar (HSc) contraction following burn injury causes contractures. Contractures are painful and disfiguring. Current therapies are marginally effective. To study pathogenesis and develop new therapies, a murine model is needed. We have created a validated immune‐competent murine HSc model. A third‐degree burn was created on dorsum of C57BL/6 mice. Three days postburn, tissue was excised and grafted with ear skin. Graft contraction was analyzed and tissue harvested on different time points. Outcomes were compared with human condition to validate the model. To confirm graft survival, green fluorescent protein (GFP) mice were used, and histologic analysis was performed to differentiate between ear and back skin. Role of panniculus carnosus in contraction was analyzed. Cellularity was assessed with 4′,6‐diamidino‐2‐phenylindole. Collagen maturation was assessed with Picro‐sirius red. Mast cells were stained with Toluidine blue. Macrophages were detected with F4/80 immune. Vascularity was assessed with CD31 immune. RNA for contractile proteins was detected by quantitative real‐time polymerase chain reaction (qRT‐PCR). Elastic moduli of skin and scar tissue were analyzed using a microstrain analyzer. Grafts contracted to ~45% of their original size by day 14 and maintained their size. Grafting of GFP mouse skin onto wild‐type mice, and analysis of dermal thickness and hair follicle density, confirmed graft survival. Interestingly, hair follicles disappeared after grafting and regenerated in ear skin configuration by day 30. Radiological analysis revealed that panniculus carnosus doesn't contribute to contraction. Microscopic analyses showed that grafts show increase in cellularity. Granulation tissue formed after day 3. Collagen analysis revealed increases in collagen maturation over time. CD31 stain revealed increased vascularity. Macrophages and mast cells were increased. qRT‐PCR showed up‐regulation of transforming growth factor beta, alpha smooth muscle actin, and rho‐associated protein kinase 2 in HSc. Tensile testing revealed that human skin and scar tissues are tougher than mouse skin and scar tissues. 相似文献
93.
Seung Min Lee Nicholas Bond Connor Callaway Benjamin Clark Emily Farmer MacKensie Mallard Seung Soon Jang 《RSC advances》2018,8(66):37866
The structural variation of multicompartment micelles is investigated using a dissipative particle dynamics simulation method for nano-reactor application. It turns out that well-defined multicompartment micelles with channel structures can be generated through the self-assembly of triblock copolymers consisting of a hydrophilic (A), a lipophilic (B), and a fluorophobic (C) block arranged in a B–A–C sequence: The corona and core are formed by the hydrophilic A block and the fluorophilic C block, respectively while the channel between the aqueous phase and core is formed by the lipophilic B block and the core. By performing a set of simulations, it is confirmed that channel size can be controlled as a function of the block length ratios between blocks A and B. Furthermore, it is also confirmed that the reactants pass through such channels to reach the micelle core by analyzing the pair correlation functions. By monitoring the change of the number of reactants in the multicompartment micelle, it is revealed that the diffusion of reactants into the core is slowed down as the concentration gradient is decreased. This work provides mesoscopic insight for the formation of multicompartment micelles and transport of reactants for use in the design of micelles as nanoreactors.The structural variation of multicompartment micelles is investigated using a dissipative particle dynamics simulation method for nano-reactor application. 相似文献
94.
Corey Heitz Justin Morgenstern Christopher Bond William K. Milne 《Academic emergency medicine》2019,26(2):246-249
This is a validation of a preplanned secondary analysis of the NEXUS II Head computed tomography (CT) decision instrument, focusing on the pediatric population. A total of 1,018 patients less than 18 years old, who underwent head CT imaging for blunt head trauma, were included. The decision instrument correctly identified all patient (27/27) who required neurosurgical intervention and 48 of 49 patients who had clinically significant head injury on CT imaging. 相似文献
95.
Biochemical and anatomical effects of antibodies against nerve growth factor on developing rat sensory ganglia. 总被引:7,自引:2,他引:7 下载免费PDF全文
M Goedert U Otten S P Hunt A Bond D Chapman M Schlumpf W Lichtensteiger 《Proceedings of the National Academy of Sciences of the United States of America》1984,81(5):1580-1584
The importance of nerve growth factor (NGF) for the development of sensory ganglia was investigated by injecting rat fetuses (16.50 days of gestation) with a single dose of anti-NGF antiserum. Four months later the treated animals showed a very large decrease in substance P- and somatostatin-like immunoreactivities in dorsal root ganglia and skin with a lesser decrease in trigeminal ganglia. Fluoride-resistant acid phosphatase, substance P-, and somatostatin-like immunoreactivities were greatly decreased in the dorsal horn of the spinal cord. No change in neurotensin- and [Met]enkephalin-like immunoreactivities was observed. The anti-NGF antiserum treatment produced a greater than 90% decrease in the number of unmyelinated dorsal root fibers and a 35% decrease in the total number of myelinated fibers. The loss in myelinated fibers was restricted to small-diameter fibers with no change in large-diameter fibers. No change in taste bud morphology was noted, thereby refuting the proposal that anti-NGF antiserum treatment may represent an animal model for familial dysautonomia. The present results indicate that NGF is a necessary requirement for the normal development of a significant population of prenatal rat dorsal root ganglion cells. 相似文献
96.
Myocardial expression of a constitutively active alpha 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy. 总被引:13,自引:0,他引:13 下载免费PDF全文
C A Milano P C Dolber H A Rockman R A Bond M E Venable L F Allen R J Lefkowitz 《Proceedings of the National Academy of Sciences of the United States of America》1994,91(21):10109-10113
Transgenic mice were generated by using the alpha-myosin heavy chain promoter coupled to the coding sequence of a constitutively active mutant alpha 1B-adrenergic receptor (AR). These transgenic animals demonstrated cardiac-specific expression of this alpha 1-AR with resultant activation of phospholipase C as shown by increased myocardial diacylglycerol content. A phenotype consistent with cardiac hypertrophy developed in adult transgenic mice with increased heart/body weight ratios, myocyte cross-sectional areas, and ventricular atrial natriuretic factor mRNA levels relative to nontransgenic controls. These transgenic animals may provide insight into the biochemical triggers that induce hypertrophy in cardiac disease and serve as a convenient experimental model for studies of this condition. 相似文献
97.
98.
Tran Dac Phu Vu Ngoc Long Nguyen Tran Hien Phan Trong Lan Wayne Lowe Michelle S. McConnell Michael F. Iademarco Jeffrey M. Partridge James C. Kile Trang Do Patrick J. Nadol Hien Bui Diep Vu Kyle Bond David B. Nelson Lauren Anderson Kenneth V. Hunt Nicole Smith Paul Giannone John Klena Denise Beauvais Kristin Becknell Jordan W. Tappero Scott F. Dowell Peter Rzeszotarski May Chu Carl Kinkade 《MMWR. Morbidity and mortality weekly report》2014,63(4):77-80
99.
Corey Heitz Justin Morgenstern Christopher Bond William K. Milne 《Academic emergency medicine》2020,27(1):64-65
The Office of the Inspector General has the authority to levy fines relating to violations of the Emergency Medicine Treatment and Labor Act (EMTALA) for both medical and psychiatric care. Terp et al. have described the incidence of violations and penalties levied for psychiatric cases and compared them to that for medical. This article reviews that article and the podcast recorded with Dr. Terp and the ensuing discussion in the podcast and online. 相似文献
100.