肝硬化失代偿合并妊娠瘢痕子宫患者中期引产一例的护理

目的探讨肝硬化失代偿期合并妊娠瘢痕子宫患者中期引产的护理方法。方法回顾性分析2010年北京佑安医院收治的1例肝硬化失代偿期合并妊娠瘢痕子宫患者的临床资料。患者入院后,即对其进行心理护理,制定有针对性的预防并发症发生的护理措施,指导患者饮食。结果经过积极有效的治疗和护理,该患者未发生严重并发症,引产过程顺利,预后良好,病情平稳后转入内科继续治疗。结论肝炎肝硬化失代偿合并妊娠瘢痕子宫的患者在实施中期引产时,风险大,并发症多。密切观察患者病情变化,采取有效的治疗措施,制定以"病人为中心"的个性化护理,是预防并发症发生和救治成功的关键。     

Optical fiber light source directs neurite growth

Guiding the growth of a neurite by directing ~800 nm laser light to the leading edge of the neurite''s growing region can be accomplished by controlling the position and direction in three dimensional space of a tapered optical fiber through which the light is projected. We control the position, angle and power of the laser beam to direct the growth of actin accumulations in neurites which affects their mobility.OCIS codes: (170.0170) Medical optics and biotechnology, (060.2390) Fiber optics, infrared, (140.0140) Lasers and laser optics     

ALK7 Gene Polymorphism is Associated with Metabolic Syndrome Risk and Cardiovascular Remodeling

Background

Activin receptor-like kinase 7 (ALK7) is a type I receptor for the TGF-β superfamily and has recently been demonstrated to play an important role in the maintenance of metabolic homeostasis.

Objective

To investigate the association of the ALK7 gene polymorphism with metabolic syndrome (MetS) and cardiovascular remodeling in MetS patients.

Methods

The single nucleotide polymorphism rs13010956 in the ALK7 gene was genotyped in 351 Chinese subjects undergoing carotid and cardiac ultrasonography. The associations of the ALK7 gene polymorphism with the MetS phenotype, MetS parameters, and cardiovascular ultrasonic features were analyzed.

Results

The rs13010956 polymorphism in the ALK7 gene was found to be significantly associated with the MetS phenotype in females (p < 0.05) and was also significantly associated with blood pressure in the total (p < 0.05) and female populations (p < 0.01). Further analysis revealed that rs13010956 was associated with mean intima-media thickness of the carotid arteries in females (p < 0.05). After control for body mass index, blood pressure, fasting blood glucose, and triglycerides, rs13010956 was also found to be significantly associated with left ventricular mass index in the total (p < 0.05) and female populations (p < 0.05).

Conclusion

Our findings suggested that the ALK7 gene polymorphism rs13010956 was significantly associated with MetS risk in females and may be involved in cardiovascular remodeling in MetS patients.     

Induction of Partial Protection against Foot and Mouth Disease Virus in Guinea Pigs by Neutralization with the Integrin β6-1 Subunit

The mechanism by which the foot-and-mouth disease virus (FMDV) initiates infection of cells is thought to involve the attachment of the viral capsid to host integrins on the surface of target cells. However, the role of integrins in FMDV infection still needs to be fully understood, although it has been demonstrated that integrin αvβ6 interferes with FMDV in vitro and results in neutralization of its infectivity. In the present study, we describe the cloning and sequencing of suckling mouse integrin β6 and the subsequent expression of two segments of integrin β6 extracellular domains: β6-1 (which contains the ligand-binding domain) and β6-2. Sequencing of the mouse integrin β6 subunit revealed close homology (~90%) with its human counterpart. When recombinant integrin extracellular domains β6-1 and β6-2 formulated with adjuvant were inoculated into guinea pigs, anti-integrin antibody expression was high before FMDV challenge. Interestingly, guinea pigs (50%) inoculated with integrin β6-1 were protected from FMDV infection; in contrast, none of the animals inoculated with integrin β6-2 were protected. This result indicates that an integrin blockade may be able to interfere with FMDV infection in vivo, which raises the possibility that targeting integrin in vivo may be the basis for a new strategy to control FMDV infection.     

Surveillance of Macrolide-Resistant Mycoplasma pneumoniae in Beijing,China, from 2008 to 2012

Macrolide resistance rates of Mycoplasma pneumoniae in the Beijing population were as high as 68.9%, 90.0%, 98.4%, 95.4%, and 97.0% in the years 2008 to 2012, respectively. Common macrolide-resistant mobile genetic elements were not detected with any isolate. These macrolide-resistant isolates came from multiple clones rather than the same clone. No massive aggregation of a particular clone was found in a specific period.     

成人型多囊肾的CT诊断

目的：探讨成人型多囊肾的CT诊断价值。材料与方法：回顾性分析15例成人型多囊肾患者的CT表现及临床表现资料。结果：15例均可见双肾满布无数个大小不等之囊性低密度影,囊腔内出血2例,囊壁钙化5例,伴肾结石9例,伴胰腺囊肿2例,伴多囊肝5例。结论：成人型多囊肾具有特征性的CT征象,CT多能准确诊断。     

手术治疗胫骨Pilon骨折的临床研究

目的探讨胫骨Pilon骨折的手术治疗时机,手术方法。方法随访1999-2003年治疗的胫骨pilon骨折40例。骨折类型:一型23例,二型9例,三型8例。25例合并腓骨骨折。胫骨最终均用解剖钢板内固定,腓骨用1/3管状钢板内固定。结果40例骨折全部愈合,参照Mazur踝关节症状与功能系统标准作功能评价,优31例,良7例,可2例,优良率95%。结论对胫骨Pilon骨折针对不同的受伤机制与骨折类型选择手术时机,最终坚强内固定治疗胫骨Pilon骨折,效果优良,可早期活动踝关节,不致功能丧失。     

年龄对吻合血管的腓骨移植术后腓骨形态的影响

[目的]探讨年龄对吻合血管的腓骨移植术后腓骨形态改变的影响。[方法]厢吻合血管的腓骨移植治疗胫骨外伤性骨缺损、感染42例，其中≤19岁者19例，≥20岁者23例。比较两个年龄组吻合血管的腓骨术后腓骨形态的改变。[结果]吻合血管的腓骨移植后，腓骨在其愈合过程中就有形态的改变。在这期间，≤19岁年龄组的腓骨形态改变更明显。术后2年，两组的腓骨形态增粗率无明显差异。[结论]年龄对吻合血管的腓骨形态的影响，主要表现在早期的移植腓骨的愈合过程期间，可能与红骨髓的含量和骨膜的成骨能力有关。     

基底动脉顶端动脉瘤GDC栓塞术后并发Terson综合征一例

患者，男，57岁，于2005年1月3日15时突然剧烈头痛、恶心伴有呕吐，即呼救护车送我院，途中病人意识不清，伴尿失禁。急诊CT检查示：脑池及部分脑沟裂高密度影呈铸型，以鞍上池为著，脑沟变浅，侧脑室略大，中线居中。考虑蛛网膜下腔出血。急诊入院。既往无高血压及遗传病史。查体：血压180／130mmHg，中度昏迷，双侧瞳孔不等大，左侧瞳孔4mm，