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排序方式: 共有9124条查询结果,搜索用时 31 毫秒
121.
Miao Hou Zhenyu Chu Ting Liu Haitao Lv Ling Sun Bo Wang 《The journal of maternal-fetal & neonatal medicine》2015,28(2):216-221
In early life, over-nutrition may increase the risk of insulin resistance in the adult stage. Adiponectin and its receptor may play a key role in this process. This study aimed to identify the effect of a high-fat (HF) maternal diet on metabolic parameters and muscle adiponectin signaling in young adult offspring. We found that offspring born to dams fed HF chow (HF; 31% of calories from fat) had elevated body and adipose tissue weight and higher serum glucose levels after glucose challenge at three weeks (W3) and eight weeks (W8) of age. Offspring exposed to a HF diet also had higher serum adiponectin levels at W3 compared to controls. However, adiponectin levels were significantly decreased compared to controls by W8. Adiponectin receptor 1?mRNA expression in skeletal muscle was decreased in the HF group at W3 and W8, and there was no difference between the two groups in adiponectin receptor 2 expression. Furthermore, glucose transporter 4?mRNA and protein expression was decreased in the skeletal muscle of the HF group at W3 and W8. Our results suggest that a HF maternal diet decreases adiponectin receptor 1 expression in the offspring, which could contribute to reduced sensitivity to adiponectin and to adverse nutritional programing outcomes. 相似文献
122.
目的 探讨艾滋病合并肺结核的临床特点及治疗。方法 对24例艾滋病合并肺结核进行回顾性分析。结果 两病并发率由1998年的0.05%上升至2002年的0.73%。HIV感染途径为静脉吸毒(77.1%)及性途径(22.9%);临床表现有发热(91.7%),咳嗽(91.7%),咳痰(79.2%),明显消瘦(79.2%),淋巴结肿大(54.7%);胸部X线表现以继发性肺结核为主(66.7%);合并病毒性肝炎50%,痰菌阳性率41.7%,PPD试验阳性率16.7%,14例抗结核治疗(3HRZE/9HRE)治愈或完成疗程,抗结核药物不良反应发生率为79.2%。结论 艾滋病合并肺结核常发病急、症状重、PPD试验阳性率低、抗结核药物治疗不良反应多,应加强艾滋病高发区及高危人群肺结核患者并发艾滋病的警惕性。 相似文献
123.
To guarantee the long-term stability of an orthopaedic implant, non-degradable surface coatings with the ability to selectively release bioactive drugs or ions are especially desirable. In this study, SrO–TiO2 composite coatings were deposited on the surface of Ti alloys, whose release behavior of bioactive Sr ions was modulated by the Sr configurations, either interstitial atoms in solid solution (TiySr2−2yO2) or strontium titanate (SrTiO3). A perfect linear relationship between the amount of the released Sr ions and the Sr content in the coating was observed. Among the SrO-doped TiO2 coatings, the 20% SrO–TiO2 coating where Sr existed in both forms of TiySr2−2yO2 and SrTiO3 not only promoted proliferation of bone cells but also enhanced their osteogenic differentiation, which was proved to be related to its Sr release behavior. However, overdosing with 30% SrO only resulted in one single Sr configuration (SrTiO3) and an inferior osteogenic function. This study suggests that Sr configurations of both interstitial atoms of the solid solution and SrTiO3 can realize the selective release of Sr, but they possibly have different effects on the biological functions and other properties including corrosion resistance.Strontium configurations can modulate its release in the SrO–TiO2 coating system, thus being able to control the interfacial osteogenesis. 相似文献
124.
Fangpeng Shu Daojun Lv Xian-Lu Song Bin Huang Chong Wang Yuzhong Yu Shan-Chao Zhao 《RSC advances》2018,8(12):6581
Since metal organic frameworks (MOF) have exhibited fascinating potential in biomedical applications, it is worthwhile to construct a MOF-based multifunctional drug delivery system. In the present study, the anticancer drug doxorubicin (DOX) was loaded into zeolitic imidazolate framework-8 (ZIF-8) via a one-pot process. The formed DOX@ZIF-8 was then coated with polydopamine, successively chelated with Fe3+ and conjugated with hyaluronic acid (HA), finally resulting in a multifunctional ZIF-8 nanocarrier. The characterization results confirmed the successful formation of the hybrid nanocarrier. pH-responsive drug release of DOX was observed due to the innate pH-dependent stability of ZIF-8. Importantly, the flow cytometry and confocal laser scanning microscope results both verified the targeting ability of DOX@ZIF-HA toward prostate cancer PC-3 cells. The improved therapeutic efficacy of DOX@ZIF-HA when compared to the inhibited group was also demonstrated. Furthermore, the chelation of Fe3+ by PDA makes the prepared DOX@ZIF-HA a good contrast agent for magnetic resonance (MR) imaging. Hence, we hope the constructed ZIF-8 based multifunctional nanocarrier could be a candidate for cancer theranostics.DOX-doped MOF nanoparticles were prepared via a one-pot reaction and successively anchored with Fe3+ and HA for simultaneous targeted drug delivery and MR imaging. 相似文献
125.
Jun Wang Shengli Li Yi Zhao Juan Shi Lili Lv Huazhi Wang Zhiya Zhang Wangjun Feng 《RSC advances》2018,8(12):6660
With a high specific capacity (4200 mA h g−1), silicon based materials have become the most promising anode materials in lithium-ions batteries. However, the large volume expansion makes the capacity reduce rapidly. In this work, a periodic silicon/carbon (Si/C) multilayer thin film was synthesized by magnetron sputtering method on copper foil. The titanium (Ti) film (about 20 nm) as the transition layer was deposited on the copper foil prior to the deposition of the multilayer film. Superior electrochemical lithium storage performance was obtained by the multilayer thin film. The initial discharge and charge specific capacity of the Si (15 nm)/C (5 nm) multilayer film anode are 2640 mA h g−1 and 2560 mA h g−1 with an initial coulombic efficiency of ∼97%. The retention specific capacity is about 2300 mA h g−1 and there is ∼87% capacity retention after 200 cycles.With a high specific capacity (4200 mA h g−1), silicon based materials have become the most promising anode materials in lithium-ions batteries. 相似文献
126.
To solve the problem of contamination of hexavalent chromium (Cr(vi)), visible-light-driven graphene-based ternary metal chalcogenide nanosheets (rGO/SnIn4S8) were synthesized via a one-pot surfactant-assisted hydrothermal method for the photoreduction of Cr(vi). Characterizations demonstrated that SnIn4S8 nanosheets were uniformly distributed on the surface of rGO and the as-synthesized nanosheets exhibited excellent photocatalytic activity under visible light. In addition, the effects of pH, concentration of critic acid, holes and electron scavengers on the reduction of Cr(vi) were systematically investigated. It was found that 50 mg L−1 of Cr(vi) could be completely removed within 30 min at pH 2 when citric acid served as a hole scavenger. Kinetic studies showed that the photocatalytic reduction of Cr(vi) processes obeyed the pseudo first order model. Further study indicated that the Cr(iii) species was immediately adsorbed onto the surface of the rGO/SnIn4S8 nanosheets after photocatalytic reduction of Cr(vi). Additionally, recycling results suggested that rGO/SnIn4S8 nanosheets possessed high recycle ability and stability after repeated use (5 times). This effective and promising work might provide a new strategy for the photoreduction of Cr(vi) and complete removal of chromium from effluent through the novel photocatalyst rGO/SnIn4S8.Fabrication of visible-light-responsive photocatalyst (rGO/SnIn4S8) for photoreduction of Cr(vi) and adsorption of Cr(iii). 相似文献
127.
The pathophysiology of delayed cerebral vasospasm (CVS) after subarachnoid haemorrhage (SAH) is multifaceted and involves endothelial apoptosis and inflammation. Ethyl pyruvate (EP) could attenuate early brain injury following SAH via anti-inflammation and inhibition of the c-Jun N-terminal kinase (JNK) signalling pathway. However, the role of EP in the delayed CVS has yet to be determined. In this study, we examined the effect of EP on endothelial apoptosis and inflammation and explore possible signalling pathways. We found that EP could significantly attenuate the delayed CVS. Possible mechanisms include a decrease in the endothelial cell apoptosis of the basilar artery and alleviation of endothelial inflammation. The JNK signalling pathway may play an important role in the neuroprotective effects of EP on delayed CVS. The results suggest that EP may be a possible therapy for delayed CVS, and the JNK signalling pathway should be targeted for therapeutic purposes in the future.The pathophysiology of delayed cerebral vasospasm (CVS) after subarachnoid haemorrhage (SAH) is multifaceted and involves endothelial apoptosis and inflammation. 相似文献
128.
Xinji Gong Yuehua Li Jing Wang Gang Wu Ayinuer Mohemaiti Qimanguli Wushouer Lidan Yao Jianghua Lv Rongrong Li Pengfei Li Buqing Wang 《RSC advances》2018,8(16):8983
Background: Despite great effort to control tuberculosis (TB), low treatment adherence threatens the success of drug therapy, increases the risk of TB transmission, and leads to the development of drug resistance. The present study assessed anti-TB treatment adherence in sputum smear-positive TB patients and examined the risk factors for poor patient adherence to identify targets for intervention. Methods: We monitored and followed up TB patients who were diagnosed between July 2014 and June 2015 in Xinjiang, China. A total of 8289 sputum smear-positive TB patients were included in this study. All patients registered their information during the first hospital visit or with the Centers for Disease Control, had regular follow-up visits, and accepted the anti-TB treatment. Insufficient re-examination adherence was defined as undergoing fewer than the recommended three sputum smear examinations during the treatment course. Results: Among 8289 patients, 3827 men (84.4% of male patients) and 3220 women (85.7% of female patients) had good adherence during treatment follow-up. 1242 patients (15.0%) did not complete regular follow-up. 332 (4.0%) patients lost contact. An adjusted logistic regression model showed that ethnicity, household address, treatment classification, patient source, and the actual management were significantly associated with non-adherence. Conclusion: The Xinjiang TB epidemic situation remains grim. Smear-positive patients had a higher proportion of non-adherence, which increased treatment difficulties and the risk of death from TB. Relevant medical departments should strengthen their supervision and interventions during the TB treatment process to improve patient adherence to anti-TB treatment.Background: Despite great effort to control tuberculosis (TB), low treatment adherence threatens the success of drug therapy, increases the risk of TB transmission, and leads to the development of drug resistance. 相似文献
129.
Xiuzhen Wei Xiaoyan Bao Jiawei Wu Cuixia Li Yingying Shi Jinyuan Chen Bosheng Lv Baoku Zhu 《RSC advances》2018,8(19):10396
The rejection behaviors of two different charged composite hollow fiber nanofiltration (NF) membranes for six pharmaceutical molecules, primidone, carbamazepine, sulfamethoxazole, atenolol, sulfadimidine and norfloxacin, were characterized in this study. The saturation adsorption behaviors of the different pharmaceutical molecules on each membrane surface were studied and found to be related to the molecular weight, charge and hydrophilicity of the pharmaceutical molecules. After the pharmaceutical molecules reached adsorption equilibrium, the rejection rates of different NF membranes were characterized. The rejection rates of primidone, carbamazepine, sulfamethoxazole, atenolol, sulfadimidine and norfloxacin by the PEI-NF membrane were 85.6%, 91.8%, 79.9%, 98.1%, 93.3%, and 97.1%, respectively. Meanwhile, the rejection rates of the pharmaceutical molecules by the PIP-NF membrane were 82.2%, 85.4%, 91.5%, 79.1%, 87% and 93.3%, respectively. The influence of feed concentration, operation pressure, temperature, pH and ionic strength on the rejection behaviors of the different charged NF membranes were also studied.The rejection behaviors of two different charged composite hollow fiber nanofiltration (NF) membranes for six pharmaceutical molecules, primidone, carbamazepine, sulfamethoxazole, atenolol, sulfadimidine and norfloxacin, were characterized in this study. 相似文献
130.