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991.
992.
Christopher C. Benz Leena Hilakivi-Clarke Suzanne Conzen Ronald V. Dorn Gini F. Fleming Kathleen Grant Geoffrey Greene Samuel Hellman Craig Henderson Robert Hoover William Hryniuk Stefanie Jeffrey Marc Lippman John Lung Malcolm Mitchell Malcolm Pike 《Breast cancer research and treatment》2001,70(3):213-219
993.
994.
995.
Xingyang XUE Yu FAN Li MA Jun CHEN Sen WEI Zhigang LI Hongyu LIU Haisu WAN Zhihao WU Qinghua ZHOU Tianjin Key Laboratory of Lung Cancer Metastasis Tumor Micro-environment Tianjin Lung Cancer Institute Tianjin Medical University Hospital Tianjin China 《中国肺癌杂志》2009,(6)
Background and Objective Lung cancer is not only the most dangerous threating tumor to humans health and life, but also a malignant tumor with poor prognosis. It has been well-known 相似文献
996.
Junke FU Zhe WANG Sen WEI Gang CHEN Zhigang LI Jun CHEN Hongyu LIU Zhihao WU Ke XU Qinghua ZHOU Tianjin Key Laboratory of Lung Cancer Metastasis Tumor Micro-environment Tianjin Lung Cancer Institute Tianjin Medical University Hospital Tianjin China 《中国肺癌杂志》2009,(6)
Backgroud and Objective Tumor metastasis is not only the malignant marker and characteristics of lung cancer, but also the main cause of failure to cure and lose their life of the patients 相似文献
997.
Xiaopeng Liang Oscar Hou In Chou Ching Lung Cheung Bernard M. Y. Cheung 《Annals of medicine》2022,54(1):1767
ObjectiveHypertension and arthritis are two common diseases in the general population, with multiple common risk factors. This study aimed to assess the association between hypertension (HTN) and arthritis.Patients and methodsThis cohort study included 48,372 eligible non-pregnant participants aged ≥ 20 years who had valid data on hypertension and arthritis from the National Health and Nutrition Examination Survey (NHANES) 1999–2018. The association between hypertension and arthritis was studied by logistic regression, adjusting for demographics, socioeconomic factors, excess sodium intake, physical activity, ever smoking, diabetes status and body mass index (BMI).ResultsAmong the participants, 48.0% (95% CI: 47.2–48.9) had hypertension and 24.5% (95% CI: 23.8–25.3) had self-reported arthritis. Hypertension was associated with arthritis [OR = 2.90, (95% CI: 2.74–3.07), p < 0.01], which remained significant [OR = 1.27, (95% CI:1.18–1.37), p < 0.01] after adjustments. Stratified by the types of arthritis, the association remained significant in rheumatoid arthritis (RA) [OR = 1.25, (95% CI: 1.11–1.41), p < 0.01] and osteoarthritis (OA) [OR = 1.32, (95% CI: 1.16–1.50); p < 0.01]. There was no clear association between hypertension and OA in participants aged 60 years old and above [OR = 1.08, (95% CI: 0.92–1.26); p = 0.37].ConclusionsIn this large nationally representative survey over 20 years, arthritis, including both RA and OA, was strongly associated with hypertension. Our study demonstrates a need for hypertension screening and blood control among patients with arthritis.
Key Messages
- Arthritis was associated with hypertension.
- Both rheumatoid arthritis and osteoarthritis are strongly associated with hypertension.
- There is an urgency for hypertension screening and blood control among patients with arthritis.
998.
Be-Sheng Kuo Chao-Hung Li Jiun-Bo Chen Yu-Yu Shiung Chia-Yu Chu Chih-Hung Lee Yaw-Jen Liu Je-Hung Kuo Cindy Hsu Hsiao-Wen Su Ywan-Feng Li Annie Lai Yueh-Feng Ho Yi-Ning Cheng Hong-Xuan Huang Meng-Chung Lung Ming-Syue Wu Fu-Hung Yang Chen-Han Lin William Tseng Jasper Yang Chia-Yin Lin Pei-Hua Tsai Heng-Kwei Chang Yi-Jen Wang Techeng Chen Shugene Lynn Mei-June Liao Chang Yi Wang 《The Journal of clinical investigation》2022,132(15)
Over the last 2 decades, omalizumab is the only anti-IgE antibody that has been approved for asthma and chronic spontaneous urticaria (CSU). Ligelizumab, a higher-affinity anti-IgE mAb and the only rival viable candidate in late-stage clinical trials, showed anti-CSU efficacy superior to that of omalizumab in phase IIb but not in phase III. This report features the antigenic-functional characteristics of UB-221, an anti-IgE mAb of a newer class that is distinct from omalizumab and ligelizumab. UB-221, in free form, bound abundantly to CD23-occupied IgE and, in oligomeric mAb-IgE complex forms, freely engaged CD23, while ligelizumab reacted limitedly and omalizumab stayed inert toward CD23; these observations are consistent with UB-221 outperforming ligelizumab and omalizumab in CD23-mediated downregulation of IgE production. UB-221 bound IgE with a strong affinity to prevent FcԑRI-mediated basophil activation and degranulation, exhibiting superior IgE-neutralizing activity to that of omalizumab. UB-221 and ligelizumab bound cellular IgE and effectively neutralized IgE in sera of patients with atopic dermatitis with equal strength, while omalizumab lagged behind. A single UB-221 dose administered to cynomolgus macaques and human IgE (ε, κ)–knockin mice could induce rapid, pronounced serum-IgE reduction. A single UB-221 dose administered to patients with CSU in a first-in-human trial exhibited durable disease symptom relief in parallel with a rapid reduction in serum free-IgE level. 相似文献
999.
1000.
Jenny C. Y. Lung Henry H. L. Chan 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2010,248(8):1117-1125