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941.
Specific application of immunological markers in acute lymphoblastic leukemia (ALL) for detection of inadequate blast cell reduction after induction therapy or early recognition of a relapse requires a precise characterization of the immunophenotype at the time of diagnosis and an understanding of the biology of the disease. Therefore, the ALL-BFM 83 study is first used to demonstrate the incidence, antigen expression and dynamics of relapse occurrence of immunological subtypes in childhood ALL. This is then followed by a discussion of the different immunological features hitherto applied for identification of residual leukemia cells in ALL (terminal deoxynucleotidyl transferase--TdT; common acute lymphoblastic leukemia-associated antigen--CALLA, CD10; various T-cell differentiation antigens; kappa/lambda labelling); these are, however, not leukemia-specific and are expressed to varying degrees by normal lymphoid progenitor cells. The sensitivity of these analyses is therefore largely determined by the markers applied and the type of investigational material. Finally, suitable markers are presented for detecting residual leukemia cells in the different immunological subtypes of ALL. Their clinical relevance still remains to be evaluated in prospective therapy studies. 相似文献
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943.
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945.
Angel Josabad Alonso-Castro Candy Carranza-álvarez Ma Catalina Alfaro-De la Torre Leonardo Chávez-Guerrero Ramón Fernando García-De la Cruz 《Archives of environmental contamination and toxicology》2009,57(4):688-696
We investigated the effect of Cd and Pb on the growth of the aquatic macrophyte Typha latifolia; the removal from the solution and the accumulation of these elements by the plant were also studied. Thus, small plants
of T. latifolia, collected from a noncontaminated site, were exposed for 10 days to Cd and Pb, in a single solution or in mixture solutions,
at two concentrations of the metals (5 and 7.5 mg/L). Our results showed that T. latifolia removed effectively Cd and Pb from solutions and was able to accumulate these metals in the roots and, to a lesser extent,
in the leaves. Our findings suggested a synergistic effect of Cd and Pb with respect to the toxicity to T. latifolia. Additionally, Cd diminished the Pb absorption by T. latifolia. Our results confirmed, using scanning electron microscopy, the internalization of Cd and Pb in T. latifolia. 相似文献
946.
Judit Segesdi Ágnes Gyuris Dénes BÁnhegyi Dalma VÖdrÖs Ágnes Bakos János MinÁrovits 《Pathology oncology research : POR》1998,4(1):52-55
Nucleic Acid Sequence Based Amplification (NASBA) is a suitable method for the quantification of HIV-1 RNA in plasma and serum
samples. Since determination of the viral load appears to be a valuable marker for the prediction of disease progression and
for monitoring the efficiency of antiretroviral therapy, the National AIDS Committee initiated the introduction of NASBA in
Hungary at the end of 1996. We obtained plasma samples from patients with ARC and AIDS of the Szt. László Hospital, Budapest.
We found an increased viral burden in untreated AIDS (CDC group C) patients compared to untreated ARC (CDC group B) patients.
In plasma samples of clinically stable ARC and AIDS patients treated with antiretroviral drugs we detected relatively low
HIV-1 RNA copy levels while similarly treated ARC and AIDS patients with progressive disease had high HIV-1 RNA copy numbers.
The CD4+ T-cell count was lower in AIDS patients compared to ARC patients, as expected. In general, there was an inverse correlation
(r = -0.487, P < 0.0001) between CD4+ T-cell counts and HIV-1 RNA levels. We concluded that measurement of HIV-1 RNA plasma level has an important role in assessing
prognosis and effects of antiretroviral therapy in HIV-infected patients. 相似文献
947.
948.
Summary In cultures of first trimester human placental villi, mitotic Hofbauer cells have been identified using a combined autoradiographic and immunostaining technique for the demonstration of HCG, a marker for Hofbauer cells. 相似文献
949.
Evaluation of conservative therapeutic approaches to Peyronie's disease (fibrotic induration of the penis). 总被引:1,自引:0,他引:1
G Ludwig 《Urologia internationalis》1991,47(4):236-239
Conservative approaches to the treatment of Peyronie's disease are limited. Irradiation is of no value because the efficacy has not been proven and it may cause tissue damage requiring or hampering subsequent surgery. Vitamin-E therapy is ineffective and is also not recommended. p-Aminobenzoate treatment has to be discontinued because of intolerance in one third of the cases, and the response rate is not superior to that of a placebo. Local infiltration of the plaques with orgotein (Peroxinorm) results in a marked improvement in just under 50% of cases and is therefore a justified approach in the early stages of the disease. It is, however, unclear how great the placebo effect and the spontaneous remission rate are. Surgery suited to the individual case must be considered in patients with severe angulation of the penis rendering introitus impossible, calcium deposits, or worsening of the condition despite injections of Peroxinorm. 相似文献
950.
Local relapses in mediastinal non-Hodgkin's lymphomas in childhood are rare. Of the 15 children treated in our hospital during the last 11 years, 2 had early local or pleural relapses. At presentation both had extensive pleural effusions, and after completion of induction therapy still some fluid in the pleural space was present. A local irradiation was not performed initially. Be review of the literature for risks and benefit of local irradiation in mediastinal non-Hodgkin's lymphoma, local irradiation in children receiving aggressive chemotherapy should only be considered in few patients; preferentially in those, with incomplete disappearance of the mediastinal tumor or, as we may conclude from our patients, incomplete disappearance of pleural effusion. 相似文献