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41.
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Pulmonary fibrolysis in a patient with idiopathic pulmonary fibrosis: improvement of clinical and radiological pattern after treatment with pirfenidone
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![点击此处可从《The clinical respiratory journal》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Francesco Varone Annelisa Mastrobattista Paola Franchi Luca Viglietta Venerino Poletti Sara Tomassetti Alessandra Dubini Linda Tagliaboschi Lucio Calandriello Alessandra Farchione Anna Rita Larici 《The clinical respiratory journal》2018,12(1):347-351
Idiopathic Pulmonary Fibrosis (IPF) is a chronic, progressive, fibrosing interstitial pneumonia associated with the histologic and/or radiologic pattern of usual interstitial pneumonia (UIP). Nowadays, the high‐resolution computed tomography pattern of “definite UIP” is enough to define a diagnosis of UIP without histological proof. This is pivotal especially in elderly patients with comorbidities. Early recognition of IPF is relevant for its prognostic implication. Some pharmacological strategies have been proposing novel molecules that tend to slow lung function decline, even though without healing fibrosis. We report a case of ex‐heavy smoker male with IPF showing clinical and radiological improvement after 11 months of treatment with Pirfenidone. The definite diagnosis was challenging and it was reached by a multidisciplinary approach. 相似文献
43.
Della Guardia Lucio Shin Andrew C. 《Journal of molecular medicine (Berlin, Germany)》2022,100(5):677-677
Journal of Molecular Medicine - 相似文献
44.
Isha Lopez M.D. Lucio Zapata B.S. Jr. Juan Jesús Sosa B.S. Clifford Rodgers B.S. Maria Ruiz B.S. Susan Oh M.D. Linda S. Hynan Ph.D. Alexa B. Kimball M.D. M.P.H. Amit G. Pandya M.D. 《Pediatric dermatology》2016,33(5):e292-e293
We performed a cross‐sectional study of Hispanic and non‐Hispanic parents of children with acne using a survey designed to determine their level of awareness of acne and its treatment; 82% of Hispanic parents and 40% of non‐Hispanic parents agreed that a health care provider should treat mild acne (p < 0.001). Hispanic parents of adolescents with acne agreed more frequently than non‐Hispanic parents that children with mild and moderate acne should be taken to a health care provider for treatment, but they tended not to visit health care providers. Future studies should aim to determine the reasons for this discrepancy, after which culturally sensitive educational programs can be developed to address this disparity. 相似文献
45.
There is an epidemic of obesity starting about 1980 in both developed and undeveloped countries definitely associated with multiple etiologies. About 670 million people worldwide are obese. The incidence of obesity has increased in all age groups, including children. Obesity causes numerous diseases and the interaction between genetic, metabolic, social, cultural and environmental factors are possible cofactors for the development of obesity. Evidence emerging over the last 20 years supports the hypothesis that viral infections may be associated with obesity in animals and humans. The most widely studied infectious agent possibly linked to obesity is adenovirus 36 (Adv36). Adv36 causes obesity in animals. In humans, Adv36 associates with obesity both in adults and children and the prevalence of Adv36 increases in relation to the body mass index. In vivo and in vitro studies have shown that the viral E4orf1 protein (early region 4 open reading frame 1, Adv) mediates the Adv36 effect including its adipogenic potential. The Adv36 infection should therefore be considered as a possible risk factor for obesity and could be a potential new therapeutic target in addition to an original way to understand the worldwide rise of the epidemic of obesity. Here, the data indicating a possible link between viral infection and obesity with a particular emphasis to the Adv36 will be reviewed. 相似文献
46.
Avigdor Leftin Jens T. Rosenberg Xuegang Yuan Teng Ma Samuel C. Grant Lucio Frydman 《NMR in biomedicine》2020,33(2)
MRI leverages multiple modes of contrast to characterize stroke. High‐magnetic‐field systems enhance the performance of these MRI measurements. Previously, we have demonstrated that individually sodium and stem cell tracking metrics are enhanced at ultrahigh field in a rat model of stroke, and we have developed robust single‐scan diffusion‐weighted imaging approaches that utilize spatiotemporal encoding (SPEN) of the apparent diffusion coefficient (ADC) for these challenging field strengths. Here, we performed a multiparametric study of middle cerebral artery occlusion (MCAO) biomarker evolution focusing on comparison of these MRI biomarkers for stroke assessment during sub‐acute recovery in rat MCAO models at 21.1 T. T2‐weighted MRI was used as the benchmark for identification of the ischemic lesion over the course of the study. The number of MPIO‐induced voids measured by gradient‐recalled echo, the SPEN measurement of ADC, and 23Na MRI values were determined in the ischemic area and contralateral hemisphere, and relative performances for stroke classification were compared by receiver operator characteristic analysis. These measurements were associated with unique time‐dependent trajectories during stroke recovery that changed the sensitivity and specificity for stroke monitoring during its evolution. Advantages and limitations of these contrasts, and the use of ultrahigh field for multiparametric stroke assessment, are discussed. 相似文献
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Clinical validation of the nursing diagnosis of ineffective protection in haemodialysis patients
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![点击此处可从《Journal of clinical nursing》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Jéssica Dantas de Sá Tinôco RN MsN Maria das Graças Mariano Nunes de Paiva RN MsN Kadyjina Daiane Batista Lucio RN Maria Isabel da Conceição Dias Fernandes RN MsN Marcos Venicios de Oliveira Lopes RN MsN PhD Ana Luisa Brandão de Carvalho Lira RN MsN PhD 《Journal of clinical nursing》2018,27(1-2):e195-e202
50.
Lucio Vera-Cabrera Jessica Ramos-Alvarez Carmen A. Molina-Torres Lydia Guadalupe Rivera-Morales Adrian Rendón Francisco Qui?ones-Falconi Jorge Ocampo-Candiani 《Journal of clinical microbiology》2014,52(8):3049-3052
In the present work, we studied the genetic diversity of Mycobacterium tuberculosis clinical isolates from patients according to their gender, age, and geographic location in Mexico. We did not observe any statistically significant differences in regard to age or gender. We found that spoligo international type 53 (SIT53) is more frequent in the northern states and that SIT119 predominates in central Mexico. 相似文献