全文获取类型
收费全文 | 53988篇 |
免费 | 3500篇 |
国内免费 | 984篇 |
专业分类
耳鼻咽喉 | 404篇 |
儿科学 | 1375篇 |
妇产科学 | 1437篇 |
基础医学 | 6426篇 |
口腔科学 | 1011篇 |
临床医学 | 4639篇 |
内科学 | 12694篇 |
皮肤病学 | 904篇 |
神经病学 | 5013篇 |
特种医学 | 1990篇 |
外国民族医学 | 2篇 |
外科学 | 6872篇 |
综合类 | 2123篇 |
现状与发展 | 1篇 |
一般理论 | 6篇 |
预防医学 | 3087篇 |
眼科学 | 763篇 |
药学 | 4432篇 |
8篇 | |
中国医学 | 1013篇 |
肿瘤学 | 4272篇 |
出版年
2023年 | 499篇 |
2022年 | 1252篇 |
2021年 | 1912篇 |
2020年 | 1228篇 |
2019年 | 1343篇 |
2018年 | 1510篇 |
2017年 | 1233篇 |
2016年 | 1312篇 |
2015年 | 1636篇 |
2014年 | 2123篇 |
2013年 | 2607篇 |
2012年 | 3533篇 |
2011年 | 3589篇 |
2010年 | 2105篇 |
2009年 | 1947篇 |
2008年 | 2930篇 |
2007年 | 3048篇 |
2006年 | 2779篇 |
2005年 | 2657篇 |
2004年 | 2391篇 |
2003年 | 2065篇 |
2002年 | 1851篇 |
2001年 | 1454篇 |
2000年 | 1383篇 |
1999年 | 1299篇 |
1998年 | 524篇 |
1997年 | 396篇 |
1996年 | 402篇 |
1995年 | 329篇 |
1994年 | 282篇 |
1993年 | 258篇 |
1992年 | 693篇 |
1991年 | 590篇 |
1990年 | 560篇 |
1989年 | 561篇 |
1988年 | 473篇 |
1987年 | 434篇 |
1986年 | 413篇 |
1985年 | 329篇 |
1984年 | 268篇 |
1983年 | 221篇 |
1982年 | 126篇 |
1979年 | 222篇 |
1978年 | 130篇 |
1977年 | 112篇 |
1974年 | 128篇 |
1973年 | 127篇 |
1972年 | 125篇 |
1971年 | 113篇 |
1969年 | 106篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
992.
Giuseppe Limongelli Teo Roselli Giuseppe Pacileo Paolo Calabró Valeria Maddaloni Daniele Masarone Lucia Riegler Rita Gravino Raffaella Scarafile Gemma Salerno Tiziana Miele Antonello D’Andrea Lucio Santangelo Massimo Romano Giovanni Di Salvo Maria Giovanna Russo Raffaele Calabró 《Internal and emergency medicine》2014,9(1):43-50
Cardiotrophin-1 (CT-1) is a member of the interleukin (IL-6) family of cytokines. Plasma CT-1 levels correlate with the left ventricle mass index in patients with dilatated cardiomyopathy and congestive heart failure (CHF). The aim of this paper was to evaluate CT-1 plasma levels, before and after cardiac resynchronization therapy CRT, and to characterizeits prognostic role in patients with CHF. Fifty-two consecutive patients (M/F = 39/13; 56 ± 11 years old) underwent clinical and echocardiographic evaluation, and blood sample collection at baseline. The same evaluation was repeated 6.4 ± 0.79 months after CRT. Patients with a decreased LV end-systolic volume by at least 15% (reverse remodeling) were considered echo responders to CRT. Twenty-nine patients (56%) were responders to CRT. After CRT, only 15 patients (29%) showed increased CT-1 after CRT. They were all non responders to CRT. A multivariate, logistic modelshowed CT-1 as an independent predictor of CRT echo response (p = 0.005; OR 0.97). During follow-up (18 ± 7 months), 21 cardiac events in 18 patients occurred. A Cox multivariable model showed plasma BNP pre-CRT (p = 0.02; CI 1.2–5.6; OR 3.1) and CT1 post-CRT (p = 0.01; CI 1.4–4.3; OR 2.7) as independent predictors of cardiac events. Analysis of CT-1 plasma levels deserves future consideration for larger, longitudinal studies in patients with CHF. 相似文献
993.
994.
Cristiano Spadaccio Federico De Marco Fabio Di Domenico Raffaella Coccia Mario Lusini Raffaele Barbato Elvio Covino Massimo Chello 《Thrombosis research》2014
Background
Advanced glycation endproducts (AGEs) and its receptors (RAGEs) are heterogeneous signaling proteins associated to diabetes and responsible of endothelial alterations leading to atherosclerosis progression and graft failure. The aim of this study was to investigate the role of statin in reducing AGEs related endothelial damage.Methods
Endothelial cell(EC) obtained from leftovers of saphenous vein grafts of non-diabetic patients were incubated with AGEs (2 and 20 μM) and subsequently treated with Simvastatin. Neutrophils (PNM) adherence, ROS production and RAGE and peroxisome proliferator-activated receptors-gamma (PPAR-γ) expression were analyzed. As clinical validation of the in vitro findings, ECs of diabetic patients in optimized glycaemic control administered with a 3 weeks Simvastatin regimen were similarly processed.Results
Simvastatin blunted the rise in PMN adhesion and ROS generation following stimulation of saphenous vein EC culture with AGEs in vitro. This effect was time dependent and was associated to an increase in PPAR-γ induction paralleled by a decrease in RAGEs expression. Parallely, data from diabetic patients administered with Simvastatin showed a similar significant reduction in PNM adhesion and ROS generation. Simvastatin treatment significantly decreased RAGEs expression in ECs from diabetic patients and determined a slight increase in PPAR-γ expression but the latter failed to reach statistical significance. Interference in the function of these two crucial pathways might be at the root of the statin antinflammatory and antithrombotic effect in the context of AGEs-associated damage.Conclusions
Despite the recently raised warning on the use of statins in the diabetic population, this study elucidates their cornerstone position in endothelial homeostasis of saphenous grafts in patients with controlled diabetes. 相似文献995.
996.
Previous studies have provided evidence that D-Asp plays a role in steroid-mediated reproductive biology in amphibians, reptiles, birds and mammals. To examine the molecular involvement of D-Asp on steroidogenic pathway regulation, we analysed the expression of StAR, P450 aromatase and 5αRed2 mRNAs in Pelophylax esculentus testis, either in relation to the reproductive cycle or D-Asp treatment. Basal StAR mRNA levels, as well as D-Asp and testosterone concentrations, were higher in reproductive than in post-reproductive frogs. D-Asp treatment increased StAR mRNA expression and immunolocalisation in both the reproductive and post-reproductive periods. In control testis, aromatase mRNA levels were higher in the post-reproductive period, but following D-Asp administration, they increased only in the reproductive period. The level of 5αRed2 mRNA was higher in reproductive frogs than in post-reproductive frogs, and it increased after D-Asp treatment only in the post-reproductive phase. Our results suggest that, in P. esculentus testis, D-Asp increases StAR mRNA in both periods, and P450 aromatase and 5αRed2 mRNAs at different points during the reproductive cycle. 相似文献
997.
998.
999.