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以氯铂酸钾为原料,经硫酸氨铂(Ⅱ)中间体制得抗肿瘤药物顺糖氨铂(Ⅱ),操作简便,总收率46.1%。 相似文献
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K R Brinker R M Dickerman T A Gonwa A R Hull J W Langley D L Long D A Nesser G Trevino R L Velez P J Vergne-Marini 《Transplantation》1990,50(1):43-49
A controlled trial was carried out in 209 primary cadaveric renal transplants to compare the effects of cyclosporine and steroids (double therapy) with those of cyclosporine in lower initial dose, azathioprine, and steroids (triple therapy). Patients have been followed 1-36 months since transplantation. Actuarial two-year graft survival (double 74%, triple 76%) and two-year patient survival (double 90%, triple 93%) were similar for both groups. Further analysis of particular risk factors including age, diabetes, HLA matching, acute renal failure, and use of sequential Minnesota antilymphocyte globulin in patients with delayed graft function also showed similar outcomes with both immunosuppressive regimens. Initial hospitalization time, rate of rejection, incidence of serious infection, and rate of rehospitalization were not different. Mean CsA doses and mean trough whole-blood levels were higher in double-therapy patients at hospital discharge but not by three months posttransplant. There were no differences between the two groups in iothalamate clearance at any time. Hypertension was more frequent six months posttransplant in the triple-therapy group (p less than 0.05). Thus, similar results were obtained with both regimens, and except for hypertension no regimen appeared to have increased side effects up to three years posttransplant. 相似文献
66.
颞颌关节继发性滑膜炎的临床诊断 总被引:5,自引:0,他引:5
颞颌关节滑膜炎分为原发性和继发性两种,颞颌关节紊乱综合症的滑膜炎为继发性滑膜炎。本文通过对106例颞颌关节紊乱综合症患者的临床检查、关节许氏位以及关节上腔造影的X线检查,同时对42例进行了关节内窥镜检查,在此基础上探讨了继发性滑膜炎的临床诊断标准.作者认为急性滑膜炎主要是以关节疼痛和滑膜血管的改变为主,慢性滑膜炎的临床症状与滑膜组织改变以及关节骨组织的改变均有关系。 相似文献
67.
Energy requirements for cancer patients and the effect of total parenteral nutrition 总被引:1,自引:0,他引:1
H W Merrick C L Long G P Grecos R S Dennis W S Blakemore 《JPEN. Journal of parenteral and enteral nutrition》1988,12(1):8-14
Limited data are available concerning resting metabolic expenditure (RME) in cancer patients and the effect of RME by varying glucose intake. This study describes the measurements on 21 patients with colorectal cancer while fasting and with incremental levels of standard TPN-glucose system by central vein. Following an overnight fast, the measured mean +/- SEM percent difference from the predicted RME for the male group was 4.13 +/- 1.67% and the female group, 2.09 +/- 2.09%. The overall mean percent difference of 2.95 +/- 1.45 suggests that colorectal cancer does not cause an increase in energy expenditure. Hepatic metastases in 11 of the patients did not influence RME. The data from the 21 patients indicate a statistically significant increase in RME with TPN compared to postabsorptive states in females of 37%, in males 21.88%, and combined of 29.88%. Progressively greater increases in RME were seen when calories provided incrementally exceeded the basal RME. Carbohydrate loading in excess of the patient's calorie need, as indicated by the respiratory quotient (RQ) greater than 1.0, results in fat synthesis and other energy-costing processes. The basal RME demonstrates that these cancer patients are not hypercatabolic, but do respond to high-level force-feeding with markedly increased metabolic expenditures. 相似文献
68.
Two patients with ureteric fistulae who were unfit for reconstructive surgery were treated by renal ablation using intra-arterial ethanol, gelfoam fragments and in one case coils. In both cases the fistulae dried-up on the same day and both patients are well and normotensive a year later. Our conclusion is that renal ablation by arterial embolization with ethanol can be a valuable alternative to surgery to treat ureteric fistulae in patients who are poor surgical risks. 相似文献
69.
基础医学教师课堂教学质量评价 总被引:5,自引:0,他引:5
为了了解本科教师的教学质量和教学效果 ,教学专家和学生评价了 14 7位基础医学教师。结果显示 ,讲师以上职称教师的教学质量明显好于初级职称教师 (P<0 .0 5 ) ,高级职称教师教学的科学性、艺术性和思想性明显好于讲师和助教 (P<0 .0 5 )。文章还对教学中存在的问题和对策进行了讨论。 相似文献
70.
低剂量甲基汞在小鼠体内分布及其对细胞周期进程的影响 总被引:3,自引:0,他引:3
连续90天饮用含甲基汞浓度为1/1000LD50、1/100LD50、1/50LD50和1/10LD50的自来水的雄性昆明小鼠,各脏器中总汞含量均高于对照组(P<0.05~0.005),并且随着染毒剂量增加,脏器中总汞含量也随之增高。同时采用FACScan流式细胞仪和“CellFIT”软件分析脾细胞周期进程,发现除1/1000LD50剂量组外,其余各剂量组从Go/G1时相进入S时相的脾细胞百分数均明显高于对照组(P<0.05),与染毒剂量呈明显正相关。表明连续经口摄入低剂量甲基汞小鼠脾细胞周期进程加快,细胞DNA复制增强。 相似文献