全文获取类型
收费全文 | 284篇 |
免费 | 18篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 17篇 |
妇产科学 | 4篇 |
基础医学 | 29篇 |
口腔科学 | 9篇 |
临床医学 | 20篇 |
内科学 | 60篇 |
皮肤病学 | 13篇 |
神经病学 | 3篇 |
特种医学 | 64篇 |
外科学 | 21篇 |
综合类 | 24篇 |
预防医学 | 14篇 |
眼科学 | 1篇 |
药学 | 8篇 |
肿瘤学 | 16篇 |
出版年
2022年 | 1篇 |
2019年 | 2篇 |
2018年 | 5篇 |
2017年 | 3篇 |
2016年 | 4篇 |
2015年 | 1篇 |
2014年 | 6篇 |
2013年 | 8篇 |
2012年 | 3篇 |
2011年 | 8篇 |
2010年 | 9篇 |
2009年 | 10篇 |
2008年 | 11篇 |
2007年 | 8篇 |
2006年 | 8篇 |
2005年 | 10篇 |
2004年 | 6篇 |
2003年 | 3篇 |
2002年 | 7篇 |
2001年 | 7篇 |
2000年 | 2篇 |
1999年 | 4篇 |
1998年 | 17篇 |
1997年 | 24篇 |
1996年 | 14篇 |
1995年 | 11篇 |
1994年 | 5篇 |
1993年 | 8篇 |
1992年 | 3篇 |
1991年 | 3篇 |
1990年 | 2篇 |
1989年 | 8篇 |
1988年 | 7篇 |
1987年 | 6篇 |
1986年 | 6篇 |
1985年 | 20篇 |
1984年 | 8篇 |
1983年 | 3篇 |
1982年 | 6篇 |
1981年 | 7篇 |
1980年 | 5篇 |
1979年 | 2篇 |
1978年 | 3篇 |
1977年 | 3篇 |
1976年 | 2篇 |
1975年 | 2篇 |
1972年 | 1篇 |
1969年 | 1篇 |
1949年 | 1篇 |
排序方式: 共有304条查询结果,搜索用时 0 毫秒
51.
52.
Ultrasonography in testicular torsion 总被引:1,自引:0,他引:1
53.
54.
Scrotal masses with a uniformly hyperechoic pattern 总被引:3,自引:0,他引:3
55.
A patient with documented hereditary angioneurotic edema was admitted for elective surgical extraction of 3 impacted 3rd molars under local anesthesia. In order to increase his C'1-INH level, he was prepared for operation with 2 units of fresh-frozen plasma 24 hours preoperatively. Postoperatively, he was observed in the ICU for 24 hours and on the ward for 2 days, and was discharged without any complications from the surgical trauma. 相似文献
56.
57.
58.
Antoon H van Lierop Neveen AT Hamdy Herman Hamersma Rutger L van Bezooijen Jon Power Nigel Loveridge Socrates E Papapoulos 《Journal of bone and mineral research》2011,26(12):2804-2811
Sclerosteosis is a rare bone sclerosing dysplasia, caused by loss‐of‐function mutations in the SOST gene, encoding sclerostin, a negative regulator of bone formation. The purpose of this study was to determine how the lack of sclerostin affects bone turnover in patients with sclerosteosis and to assess whether sclerostin synthesis is decreased in carriers of the SOST mutation and, if so, to what extent this would affect their phenotype and bone formation. We measured sclerostin, procollagen type 1 amino‐terminal propeptide (P1NP), and cross‐linked C‐telopeptide (CTX) in serum of 19 patients with sclerosteosis, 26 heterozygous carriers of the C69T SOST mutation, and 77 healthy controls. Chips of compact bone discarded during routine surgery were also examined from 6 patients and 4 controls. Sclerostin was undetectable in serum of patients but was measurable in all carriers (mean 15.5 pg/mL; 95% confidence interval [CI] 13.7 to 17.2 pg/mL), in whom it was significantly lower than in healthy controls (mean 40.0 pg/mL; 95% CI 36.9 to 42.7 pg/mL; p < 0.001). P1NP levels were highest in patients (mean 153.7 ng/mL; 95% CI 100.5 to 206.9 ng/mL; p = 0.01 versus carriers, p = 0.002 versus controls), but carriers also had significantly higher P1NP levels (mean 58.3 ng/mL; 95% CI 47.0 to 69.6 ng/mL) than controls (mean 37.8 ng/mL; 95% CI 34.9 to 42.0 ng/mL; p = 0.006). In patients and carriers, P1NP levels declined with age, reaching a plateau after the age of 20 years. Serum sclerostin and P1NP were negatively correlated in carriers and age‐ and gender‐matched controls (r = 0.40, p = 0.008). Mean CTX levels were well within the normal range and did not differ between patients and disease carriers after adjusting for age (p = 0.22). Our results provide in vivo evidence of increased bone formation caused by the absence or decreased synthesis of sclerostin in humans. They also suggest that inhibition of sclerostin can be titrated because the decreased sclerostin levels in disease carriers did not lead to any of the symptoms or complications of the disease but had a positive effect on bone mass. Further studies are needed to clarify the role of sclerostin on bone resorption. © 2011 American Society for Bone and Mineral Research 相似文献
59.
5 风险评估对病人的复发风险进行评估以确保只有高危病例才被施予极强治疗.研究表明采用成人方案治疗的青少年病人,其效果要显著差于使用儿童方案治疗的同年龄组. 相似文献