中国人与白种人鼻咽癌的发病和治疗

对1971—1990年间加拿大不列颠哥伦比亚癌症中心收治的428例鼻咽癌病人的发病和治疗情况进行分析。其中,中国人占303例(71％),白种人116例(27％)。中国人在该省鼻咽癌的年发病率是白种人的64倍,其中又以在中国出生的发病率最高,分别为白种人的104倍和北美出生的中国人的16倍。本组总的5年和10年生存率分别为51％和39％,颈淋巴结阴性的病人5年生存率达64％;而阳性的病人只有44％。鼻咽癌的预后与它的临床分期、病理类型、治疗前有无做颈淋巴结活检,以及性别有关,而与病人的人种和出生地无关。     

中医药抗消化性溃疡复发的研究

总结了运用中医药疗法对68例消化性溃疡愈合后的患者追踪观察2～4年的临床疗效,显示其具有复发率低的优势;又根据消化性溃疡发生及复发的机制分析了所采用的预防性治疗措施的作用机理;还对溃疡病复发的一些相关问题作了简单论述。     

雷公藤氯内酯醇对大鼠异位心脏移植免疫抑制作用的实验研究

本研究应用纯系大鼠（Ｌｏｕ→Ｆ３４４）心脏移植模型，比较分析了ＣｓＡ和不同剂量Ｔ４治疗组的移植心脏存活时间、病理损害计分以及移植受体大鼠脾单个核细胞ＩＬ－２生成活性和血清ｓＩＬ－２Ｒ水平，证实Ｔ４可明显延长移植心脏存活时间和减少移植排异反应程度。此研究结果表明Ｔ４具有较强的抗移植排异作用。     

产后4个月内未能坚持纯母乳喂养的因素分析

通过239对母婴产后4个月的跟踪随访发现,在130位母亲未能自始至终坚持纯母乳喂养的因素中,最主要的是自觉奶量不够或者因孩子哭吵、怕孩子吃不饱而添加辅助液体或食品,其次是按旧习惯从出生后3个月起添加米糊类食品,以及医务人员的错误指导和母亲上班等。纯母乳喂养的关键在于必须排除一切干扰,增强母亲的信心。因此,尽快转变旧观念,大力宣传出生后4～6个月纯母乳喂养的重要性,普及泌乳生理知识和哺乳中常见问题的处理方法,加强随访工作,是提高4个月内纯母乳喂养率的重要措施。     

TCM treatment of retinal vein occlusion in 216 cases

Traditional Chinese Medicine was adopted in the treatment of 216 cases (219 eyes) of retinal vein occlusion. The period of treatment averaged 3 months; the total rate of efficacy was 80.4%. During an average follow-up of 3 years, 84.1% of the patients maintained a stable or slightly improved vision. The authors believed that treatment of the disease with TCM promoted the absorption of blood and formation of collateral circulation, and suppressed neovascularization, thus preventing repeated bleeding that would lead to serious complications.     

杂多阴离子对SiO_2细胞毒性的拮抗作用

本文采用离体细胞培养法,以细胞存活率、乳酸脱氢酶活性和酸性磷酸酶活性为指标,研究了几种α-Keggin结构的杂多阴离子对石英粉尘细胞毒性的影响。结果表明,与对照组比较,所用杂多阴离子无细胞毒性(P>0.05),石英尘经杂多阴离子作用后,细胞毒性显著降低,与石英尘组比较,上述三项指标差异均有显著意义(P<0.01),由此表明杂多阴离子对石英的细胞毒性有明显的拮抗作用。     

Effect of a single dose of the selectin inhibitor TBC1269 on early and late asthmatic responses

BACKGROUND : Selectins participate in the initial phase of leucocyte migration from circulation to inflamed tissues and may play a role in inflammatory cellular influx into airways in asthma. In the sheep asthma model, TBC1269, a pan-selectin antagonist, reduced late allergen response by 74%. OBJECTIVE : To determine whether a single dose of TBC1269 inhibits early (EAR) and late (LAR) asthmatic responses, and whether it inhibits sputum leucocyte influx after inhalation allergen challenge in atopic asthmatic subjects treated with bronchodilators only. METHODS : Twenty-one asthmatic subjects (mean+/-SD, age=32.5+/-6.7 years, 8 males, FEV1 percent predicted=84+/-15%) with known late asthmatic response based on a screening inhalation allergen challenge were randomly assigned to receive intravenous treatment with either placebo (n=11) or TBC1269 (n=10, 30 mg/kg) infused over 15 min immediately prior to a second (post-treatment) allergen challenge at least 4 weeks after the screening challenge. After each challenge, EAR and LAR were monitored for 7 h. In addition, sputum was induced 1 day before and 1 day after each allergen challenge. RESULTS : TBC1269 did not attenuate the EAR compared with placebo (largest fall in FEV1 within 1 h of 34.1+/-13.9% vs. 31.8+/-12.2% for TBC1269 and placebo groups respectively, P=0.61) or the LAR (largest fall in FEV1 between 3 and 7 h of 39.3+/-15.3% vs. 32.6+/-13.8%, P=0.24). TBC1269 had only minor effects on allergen-induced sputum eosinophilia. CONCLUSION : We conclude that TBC1269 administered before allergen challenge as a single intravenous dose does not attenuate early or late asthmatic responses to allergen in asthmatic subjects.     

脑心通对颈动脉粥样硬化症患者临床症状及IMT的影响

目的：观察脑心通胶囊对颈动脉粥样硬化症患者临床症状及颈动脉内膜中层厚度（IMT）的影响。方法：对照组102例单用尼莫地平20mg，每日3次；治疗组102例在对照组基础上加脑心通胶囊2粒（0．8g），每日3次。总疗程3个月，比较两组治疗前后临床症状及IMT情况。结果：治疗组临床症状缓解总有效率93．14％，IMT明显改善，均优于对照组。结论：脑心通治疗颈动脉粥样硬化症有效。