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931.
Liu Ying-qi刘英奇 Yang Ji-fang杨济芳崇 Zhang Zhen-yu张振宇Zhang Xi-lan张希兰Qi Cui-e祁翠娥 Song Xiu-jun宋秀君Yang Jing-xia杨景霞and Wei Su-zhen魏素珍The Third Teaching Hospital Hebei Medical College Shijiazhuang 《中华医学杂志(英文版)》1988,101(4):280-283
Lactic dehydrogenase (LDH) activity in aqueoushumour and serum was measured of 24 patients withretinoblastoma, senile cataract, glaucoma, and cho-roid melanoma in addition to LDH isoenzyme fractions. The results were compared with those of the20 normal children. The ratio of aqueous humourLDH to serum LDH was 4.32+2.80, and that ofisoenzymes LDH4 to LDHl was greater than l. Theresults of our study suggested that the total LDHactivity and isoenzyme fractions in the aqueoushumour is of value in the diagnosis of retinobla&toma. 相似文献
932.
影响妇女生育率的直接因素,如妇女已婚比、避孕及人工流产等的定量分析是卫生人口统计分析中的重要内容。本文应用美国人口学者Bongaarts提出的中介生育率变量模型就重庆城乡妇女生育率直接影响因素作一定量研究 相似文献
933.
本文采用经Sephadex G-200层析后的旋毛虫幼虫抗原对实验感染旋毛虫大鼠和旋毛虫病人血清作间接血凝试验(IHA)。结果表明,20只大鼠感染后第16天全部出现阳性反应。9例旋毛虫病患者为阳性。本试验用于囊虫病、华枝睾吸虫病和健康人及正常大鼠均为阴性。检查本地区31只狗,阳性符合率为66.7%。 相似文献
934.
The glucuronide conjugates of oroxylin A and two other flavones, baicalein, and wogonin, were isolated from the methanol extract of the herb scutellariae radix (Huang Qin) and were found to be inhibitors of rat liver NAD(P)H:quinone acceptor oxidoreductase (EC 1.6.99.2). Baicalin (baicalein 7-O-glucuronide) and oroxylin-A 7-O-glucuronide are approximately 50-fold more potent than wogonin 7-O-glucuronide. The enzyme kinetic analysis revealed that oroxylin-A 7-O-glucuronide is a competitive inhibitor with respect to NADH (the electron donor), with a Ki value of 63 nM. Considering the similarities of their structures and inhibition kinetics to those of dicoumarol, it is thought that oroxylin-A 7-O-glucuronide and the other two flavonoids bind to an identical site and inhibit this quinone reductase in the same fashion as dicoumarol. The results also suggest that the inhibition of NAD(P)H:quinone acceptor oxidoreductase or another vitamin K reductase by oroxylin-A 7-O-glucuronide and the related flavonoids may be one of the steps associated with the anticoagulation action of the herb. These compounds are potentially useful anticoagulant drugs. 相似文献
935.
研究了10例正常人和29例急性淋巴细胞性白血病(急淋)患者外周血糖皮质激素受体高、低亲和力结合位,或(GCRH、GCRL),利用Ru38486对GCRL进行封闭,对部分患者GCRH、GCRL在激素联合化疗前后水平的变化进行了动态观察。结果表明,正常对照组GCRH、GCRL分别为4608±1889位点/细胞和135238±88509位点/细胞,两者相关良好。急淋患者GCRH、GCRL分别为6052±3888位点/细胞和126405±102133位点/细胞,经过糖皮质激素药物联合化疗后,其水平分别为3616±1962位点/细胞和143597±112289位点/细胞,GCRH下降明显(P<0.01),下降率为40.3%;而GCRL化疗前后差异不显著(P>0.05)。提示GCRL在介导糖皮质激素联合化疗疗效的维持中起重要的作用。 相似文献
936.
To study the phenotypic specificity of S-100 beta and insulin-like growth factor II (IGF-II) for developing monoamine neurons, serotonin (5-HT) neurons from the embryonic day 14 (E14) rostral raphe or dopamine (TH) neurons from the substantia nigra/ventral tegmental area were cultured for 3 days in vitro (3 DIV) in the presence of these factors. Neuronotrophic effects were analyzed by computer-assisted morphometry of 5-HT and TH-immunoreactive neurons. S-100 beta and IGF-II differentially regulated the growth of 5-HT and TH neurons but did not affect their survival. S-100 beta significantly increased several parameters of neurite outgrowth by 5-HT neurons but inhibited the spatial extent (field area) of TH neurites. IGF-II promoted growth of cell bodies of both phenotype, but only stimulated neurite outgrowth by TH neurons. S-100 beta and IGF-II differentially affected the number of GFAP immunoreactive cells from raphe and substantia nigra, but these effects did not correlate with the specificity of neuronotrophic effects. S-100 beta and IGF-II immunoreactivities were expressed in glial cultures derived from the same brain regions, raising the possibility that these factors have autocrine effects on glia as well as paracrine actions on neurons. The results of this study suggest that specificity of neurotrophic factors for particular embryonic neurons may be correlated with their neurotransmitter phenotype. 相似文献
937.
雷公藤氯内酯醇对大鼠异位心脏移植免疫抑制作用的实验研究 总被引:2,自引:0,他引:2
本研究应用纯系大鼠(Lou→F344)心脏移植模型,比较分析了CsA和不同剂量T4治疗组的移植心脏存活时间、病理损害计分以及移植受体大鼠脾单个核细胞IL-2生成活性和血清sIL-2R水平,证实T4可明显延长移植心脏存活时间和减少移植排异反应程度。此研究结果表明T4具有较强的抗移植排异作用。 相似文献
938.
低剂量电离辐射对小鼠免疫器官cAMP和儿茶酚胺含量的影响 总被引:2,自引:0,他引:2
本文报道,75mGy/(12.5mGy/min)单次全身X射线照射后9小时用SRBC免疫C57BL/6小鼠,在免疫后4天和7天脾脏、胸腺和下丘脑cAMP含量均降低;而在免疫后4天脾脏去甲肾上腺素、肾上腺素和酪氨酸含量均增高,免疫后7天肾上腺素含量仍持续增高;当连接γ射线65mGy(0.015mGy/min,6h/d)全身照射小鼠后即刻或29小时后免疫,脾脏和下丘脑cAMP含量也均降低。提示,低剂量 相似文献
939.
Traditional Chinese Medicine was adopted in the treatment of 216 cases (219 eyes) of retinal vein occlusion. The period of treatment averaged 3 months; the total rate of efficacy was 80.4%. During an average follow-up of 3 years, 84.1% of the patients maintained a stable or slightly improved vision. The authors believed that treatment of the disease with TCM promoted the absorption of blood and formation of collateral circulation, and suppressed neovascularization, thus preventing repeated bleeding that would lead to serious complications. 相似文献
940.