视盘地形测量基线与原发性开角型青光眼进展相关高眼压治疗研究中关于共焦扫描激光眼底镜的辅助研究

目的：在高眼压的患者中研究共焦扫描激光眼底镜（CSLO）关于视盘地形的基线测量是否与原发性开角型青光眼（POAG）的发展有关。     

Case-control study of factors that trigger inflammatory bowel disease flares

AIM:To explore the association between inflammatory bowel diseases(IBD)flares and potential triggers.METHODS:Patients evaluated for an acute flare of IBD by a gastroenterologist at the Dallas VA Medical Center were invited to participate,as were a control group of patients with IBD in remission.Patients were systematically queried about nonsteroidal anti-inflammatory drug use,antibiotic use,stressful life events,cigarette smoking,medication adherence,infections,and travel in the preceding 3 mo.Disease activity scores were calculated for each patient at the time of enrollment and each patient’s chart was reviewed.Multivariate regression analysis was performed.RESULTS:A total of 134 patients with IBD(63 with Crohn’s disease,70 with ulcerative colitis,and 1 with indeterminate colitis)were enrolled;66 patients had flares of their IBD and 68 were controls with IBD in remission(for Crohn’s patients,average Crohn’s disease activity index was 350 for flares vs 69 in the controls;for UC patients,Mayo score was 7.6 for flares vs 1 for controls in those with full Mayo available and 5.4p for flares vs 0.1p for controls in those with partial Mayo score).Only medication non-adherence was significantly more frequent in the flare group than in the control group(48.5%vs 29.4%,P=0.03)and remained significant on multivariate analysis(OR=2.86,95%CI:1.33-6.18).On multivariate regression analysis,immunomodulator use was found to be associated with significantly lower rates of flare(OR=0.40,95%CI:0.19-0.86).CONCLUSION:In a study of potential triggers for IBD flares,medication non-adherence was significantly associated with flares.These findings are incentive to improve medication adherence.     

13个让你变老的习惯

正你比你的实际年龄看上去要老?如果你不喜欢看到镜子中的你,那可能是时候来评估你的一些日常行为、饮食习惯甚至你睡觉的方式了。这些事情会让你加速老化,也许还会缩短你的寿命。现在,我们将讨论最常见的一些坏习惯及其改善的方法。     

涂鸦的反叛魅力

在时刻都有无数新鲜诞生的时尚圈里，如果只能用两个字概括近年以至今后时尚流转的大主题，那就是“反叛”，那天马行空的想象力，无拘无束的涂抹勾勒，其所洋溢着的危险，诱惑，破坏规则的放纵快感，构成了涂雅艺术的无穷魅力。     

辣妈教子手记（4）

学习成绩VS素质教育 前面有些朋友“指责”我不应该过于关注孩子的成绩,而应该关注他身心健康发展,注重其素质教育。在此俺想“自辩”一下,我承认我确实比较在乎孩子的成绩,但并没有“只”在乎孩子的成绩,我认为孩子成绩优秀与品格优良、身心健康是并行不悖的,它们之间并没有非此即彼的绝对排斥关系。     

Assessment of breast cancer response to neoadjuvant chemotherapy: is volumetric MRI a reliable tool?

The purpose of this study was to evaluate the reliability of volumetric magnetic resonance imaging (MRI) in breast cancer size assessment before, during and after neoadjuvant chemotherapy (NAC).Volumetric MRI measures performed on 15 patients with breast cancer were compared with volumes reckoned upon mean lesional diameters, using the same MRI data. Concordance correlation coefficient (CCC), Bland & Altman plots, RECIST evaluation and Cohen's Kappa were assessed, to evaluate the agreement between the two methods.CCC was computed before (0.9357), during (0.8053) and after (0.7499) NAC, in all examinations pooled together (0.8617), and on final tumor volume as a percentage of baseline volume (0.9224). In 2/15 (13.3%) cases RECIST assessment was different. Cohen's Kappa was 0.787 (CI_95% = 0.513-1.062).In summary, volumetric MRI is a reliable tool to assess breast cancer size before, during and after NAC. Further investigations are needed to understand whether improvements in surgical planning are feasible.     

BACTEC MGIT 960培养结合INNO-LIPA~(TM) RIF.TBDNA探针新技术快速诊断结核病

目的通过MGIT960培养系统结合国外最新的INNO -LIPATM RIF.TB(LIPA)DNA探针技术的应用 ,探讨其快速诊断结核病的可行性。方法应用BACTECMGIT960系统进行临床疑似结核病例标本的培养 ,筛选了70例结核分枝杆菌 ,35例非结核分枝杆菌 ,用LIPA探针技术诊断是否为结核分枝杆菌。结果用LIPADNA方法在70例结核分枝杆菌中获得阳性69例 ,占98.6 % ;35例非结核分枝杆菌均为阴性。与单纯消化纯化后涂片的82.9 % (58/70)的阳性率相比增加了15.7个百分点 ,两者在统计学上差异有显著性(P<0.05)。BactecMGIT960培养结合LIPADNA探针与传统诊断方法4～8周相比 ,整个过程只需6～37天 ,平均15天 (2周 )。结论LIPADNA探针是一种具有高度敏感性和特异性、能够简便、快速、准确地诊断结核病的新技术。同时还能鉴定rpoβ 基因位点的突变 ,诊断耐利福平 (RMP)性结核 ,有望适用于结核分枝杆菌耐RMP性结核的快速检测 ,进一步为结核病快速准确的治疗提供理论依据。     

60天,培养宝宝好习惯

还有1天小时44分10秒,一一宝贝儿就满60天了。回想起刚面对这个才出．生的小家伙时,一一妈手足无措。接下来亲自带宝宝的切身一体会,更让一一妈明白：要带好一个小宝宝,对于新妈妈来说,筒直就是一质铁人全能训练瓿。目——你要时刻关注宝宝的饮食起居;：还要仔细观察宝宝的喜怒哀乐;     

2岁半宝宝的入园准备

<正>离格格上幼儿园只有2个月时间了,入园准备正在紧张地进行着。我认为,进入幼儿园对于格格来说非常重要,这将是她人生的第一个转折点。因此,我在6月份就给格格设立了一个奖惩表,分吃饭、睡觉、大小便、洗脸刷牙、哭闹5项,每项达到要求,可以得到一颗五角星,一周达到25颗以上,可以外出参加活动。     

做一对上床睡觉的好夫妻

晚上孩子睡着了,照例两人一人一个房间,一人一台电脑。这不知道是多久前形成的习惯了,似乎从来就没有想过有什么不对劲。MSN上跳出一个久不联系的好友。跟我说她结婚了。朋友来自单亲家庭,离异源于父亲的背叛。所以她对男人有种天生的恐惧与不信任。