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排序方式: 共有132条查询结果,搜索用时 31 毫秒
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目的:通过植入一种新型的可调节折叠人工晶状体1CU,观察患者术后远近视力,观察改型人工晶状体的拟调节力。方法:对10眼单纯老年性白内障患者实施超声乳化联合囊袋内可调节折叠人工晶状体植入术,同期随机抽取10眼单纯老年性白内障行超声乳化及单焦点折叠晶状体植入术作为对照,于术前、及术后1wk;1,3mo查裸眼远近视力、矫正视力,并进行主客观验光。结果:1CU组裸眼近视力优于对照组(0.01〈P〈0.02),裸眼远视力及矫正远近视力无显著差异(P,0.2),两组手术前后散光无显著差异(P〉0.05)。结论:植入可调节折叠人工晶状体后,术眼具有一定的假晶状体调节。 相似文献
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Activation of the mTOR signalling pathway is required for pancreatic growth in protease-inhibitor-fed mice 总被引:1,自引:0,他引:1
Stephen J. Crozier M. Dolors Sans LiLi Guo Louis G. D'Alecy John A. Williams 《The Journal of physiology》2006,573(3):775-786
Cholecystokinin (CCK)-induced pancreatic growth in mice involves parallel increases in DNA and protein. The mammalian target of rapamycin (mTOR) signalling pathway regulates mRNA translation and its activation is implicated in growth of various tissues. The aim of this study was to elucidate whether mTOR activation is required for pancreatic growth in a mouse model of increased endogenous CCK release. In mice fed chow containing the synthetic protease inhibitor camostat, protein synthetic rates and phosphorylation of two downstream targets of mTOR, eukaryotic initiation factor 4E binding protein 1 (4E-BP1) and the ribosomal protein S6 (S6), increased in comparison with fasted controls. The camostat-induced increases in protein synthesis and 4E-BP1 and S6 phosphorylation were almost totally abolished by administration of the mTOR inhibitor rapamycin 1 h prior to camostat feeding. In contrast, the phosphorylation of ERK1/2 and JNK and the expression of the early response genes c-jun , c-fos , ATF3 and e gr-1 induced by camostat feeding were not affected by rapamycin. In mice fed camostat for 7 days, the ratio of pancreatic to body weight increased by 143%, but when rapamycin was administered daily this was reduced to a 22% increase. Changes in pancreatic mass were paralleled by protein and DNA content following camostat feeding and rapamycin administration. Moreover, while BrdU incorporation, an indicator of DNA synthesis, was increased to 448% of control values after 2 days of camostat feeding, rapamycin administration completely inhibited this increase. We conclude that the mTOR signalling pathway is required for CCK-induced cell division and pancreatic growth. 相似文献
34.
目的探讨Prader5型女性假两性畸形的畸形特征与矫治方法。方法对1994年5月至2004年8月阜阳市人民医院收治的18例Prader5型女性假两性畸形患者进行研究,在观察畸形特征的基础上,设计并实施矫治手术,进而对手术效果进行前瞻性研究。结果Prader5型女性假两性畸形有4大畸形特征;针对畸形特征,对18例患者实施了手术矫治,效果满意;首次提出对女性假两性畸形的手术分度诊断。结论根据畸形特征设计的Prader5型女性假两性畸形矫治手术新颖、科学、操作简单、对患者损伤小,效果好,值得推广;手术分度诊断对女性假两性畸形的畸形程度和手术难易的判断及术后康复指导有一定意义。 相似文献
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目的探讨电解质饮料并双歧杆菌活菌对重度脑损伤术后抗生素相关性腹泻(AAD)的治疗作用。方法将66例重度脑损伤术后AAD患者随机分成2组:研究组予电解质饮料+双歧杆菌活菌治疗,对照组予常规补液+口服相应抗生素;在治疗前后观察抗生素使用情况,治疗期间观察患者体温、腹泻、血白细胞、电解质指标恢复时间及粪便细菌涂片。结果在2组抗生素使用率相同情况下,研究组疗效优于对照组(P0.05)。结论应用电解质饮料+双歧杆菌活菌治疗AAD经济、疗效显著、患者恢复快、无毒副作用。 相似文献
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Thymic development proceeds through several defined stages that generate not only alpha beta and gamma delta T cells but can produce dendritic cells and B cells. The earliest thymocytes exist in the CD4(-)CD8(-) double negative compartment within a heterogeneous fraction termed DN1. Recent progress has identified several candidate populations that may be the bone fide T-cell progenitor population. The potential roles of these populations, which include hematopoietic stem cells, early lymphocyte precursors, common lymphoid progenitors, and early T lineage progenitors are being elucidated. The alpha beta T-cell lineage consists of distinct subsets, one of which is NKT cells. The developmental relationship of NKT cells to conventional T cells has been controversial. Recent work has shown that these cells are probably derived from CD4(+)CD8(+) thymocytes. The discovery and application of CD1d tetramers has made it possible to more fully describe NKT-cell development. 相似文献
38.
目的:通过对胃肠外营养(TPN)采用三升袋榆注全营养混和液(TNA)能有效的降低静脉炎发生率。方法:将100例病人随机分两组,A组50人采用TNA三升袋混和后输注;B组50人采用单瓶输注或多瓶串联输注,对两组发生静脉炎情况进行比较.结果:A组静脉炎发生率为30%;B组静脉炎发生率为50%,两组比较有显著差异(P〈0.05)。结论:采取相应有效措施和护理,达到预防和减少静脉炎的发生。 相似文献
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Dawson M. Gerhardt Kostandin V. Pajcini Teresa D’altri LiLi Tu Rajan Jain Lanwei Xu Michael J. Chen Stacey Rentschler Olga Shestova Gerald B. Wertheim John W. Tobias Michael Kluk Antony W. Wood Jon C. Aster Phyllis A. Gimotty Jonathan A. Epstein Nancy Speck Anna Bigas Warren S. Pear 《Genes & development》2014,28(6):576-593