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141.
Recruitment and screening policies and procedures used to establish a paid donor oocyte registry 总被引:3,自引:2,他引:1
We have reviewed the demographic characteristics of, and report
abnormalities noted in, the de-novo growth and development of a paid oocyte
donation programme. The personal profiles of all prospective oocyte donors
were reviewed. Acceptance or rejection of candidates was based upon
screening the results of medical, genetic and psychological testing. A
total of 603 candidates initially responded to our advertisement. From this
pool, 313 individuals were considered suitable and contacted by telephone.
Following further conversation, 176 women were scheduled an entry
interview. On completion of the formal screening process, 17.6% (n = 31) of
those actually interviewed were denied entry. Thus, from the initial
interested parties, only 23% of women wishing to participate in oocyte
donation were considered suitable candidates. Given the high attrition
rate, we concluded that the need for rigorous and thorough medical,
psychological and genetic testing is mandatory for the establishment of a
donor registry. Furthermore, professional counselling of prospective donors
with respect to the results of tests and the implications of test results
with respect to their future medical and reproductive health, are important
parts of providing comprehensive care.
相似文献
142.
143.
d,l-15(R)-15-Methyl-PGF2α methyl ester 11-trimethylsilyl ether(II)wasprepared from selective monosilylation of d,l-15(R)-15-methyl-PGF2αmethyl ester(I) withtrimethylsilyldiethylamine in acetone. Oxidation of(II ) with Collin's reagent gave d,l-15(R)-15-methyl-PGE2 methyl ester 11-trimethylsilyl ether(III)which,without purification,was converted to d,l-15(R)-15-methyl-PGE2 methyl ester(IV)under mild acidic conditions. 相似文献
144.
145.
Prevention in practice: results of a 2-year follow-up of routine health promotion interventions in general practice 总被引:2,自引:0,他引:2
BACKGROUND.: The effectiveness of health promotion activity in general practiceon risk factor reduction for coronary heart disease remainsthe subject of active debate. OBJECTIVE.: The study aimed to assess the impact of practice-based healthcheck-ups on health behaviours over a 2-year period. METHOD.: A general practice cohort of 7123 patients from 18 practiceswas surveyed. Eight hundred and forty (12%) patients had beenoffered a heafth check within a 12-month period from September1992 and 621 (9%) received one. Two hundred and fifty patients(40%) were asked back for follow-up after their health check. RESULTS.: Over a 2-year period there was no difference in smoking cessation,alcohol consumption, weight loss nor the amount of exercisetaken between those who attended for a health check and thosewho did not. The food score chosen to assess dietary change(Oxcheck) showed a statistically significant 1.16-point risefor the whole sample over the survey period. There was a significantdifference in mean food score change between heafth check attendersand non-attenders (Mann-Whitney U test: P << 0.002). Maintenanceof dietary improvement over a 2-year period was not affectedby health check attendance. CONCLUSIONS.: This study confirms the low impact of health checks on the selfreported modification of cardiovascular risk factors and showsthat maintenance of appropriate health behaviour change is nomore likely in those who have received a health check. Keywords. Health promotion, general practice. 相似文献
146.
Quantitative liver function in patients with rheumatoid arthritis treated with low-dose methotrexate: a longitudinal study 总被引:4,自引:0,他引:4
Beyeler C; Reichen J; Thomann SR; Lauterburg BH; Gerber NJ 《Rheumatology (Oxford, England)》1997,36(3):338-344
The objectives were to determine quantitative liver function prospectively
in patients with rheumatoid arthritis (RA) treated with low-dose
methotrexate (MTX), to search for risk factors for a loss of quantitative
liver function and to assess the relationship between quantitative liver
function and histological staging. A total of 117 patients with RA (ACR
criteria, 85 women, mean age 59 yr) had measurements of galactose
elimination capacity (GEC), aminopyrine breath test (ABT) and liver enzymes
[aspartate amino transferase (AST), alanine amino transferase (ALT),
alkaline phosphatase (AP), 7-glutamyl transferase (GGT), bile acids,
bilirubin, albumin] before treatment with weekly i.m. MTX injections and
every year thereafter. In 16 patients, liver biopsies were performed.
Before the introduction of MTX, mean GEC was 6.6 mg/min/kg [5th to 95th
percentile (5-95 PC) 5.1- 8.5; reference range 6.0-9.1] and mean ABT was
0.80% kg/mmol (5-95 PC 0.42-1.30: reference range 0.6-1.0). During
treatment with MTX [mean weekly dose 11.8 mg (5-95 PC 5.4-20.2), mean
observation period 3.8 yr (5-95 PC 0.4-6.9)], significant declines of GEC
(-0.12 mg/min/kg per year. t = 3.30, P < 0.002) and ABT (-0.06% kg/mmol
per year, t = 4.81, P < 0.001) were observed. Negative correlations were
found between the annual change in GEC and GEC at baseline (Rs = -0.40, P
< 0.0001), and the annual change in ABT and ABT at baseline (Rs = -0.43,
P < 0.0001). No correlations were found between the annual change in GEC
or ABT and weekly MTX dose, age or percentage of increased liver enzymes,
and no effect of a history of alcohol consumption > 30 g/week became
evident. Two patients with Roenigk grade III had impaired quantitative
liver function, while 14 patients with Roenigk grades I and II exhibited a
high variability of GEC and ABT from normal to abnormal values. The
continuous declines in GEC and ABT observed deserve attention in patients
with prolonged treatment. Patients with a low GEC or ABT at baseline seem
not to be at increased risk for a further loss of quantitative liver
function. An impaired GEC or ABT does not necessarily concur with hepatic
fibrosis on histological examination.
相似文献
147.
Hospital Discharge Rates and Deaths from Asthma in the Hunter Health Region (NSW) 1971–72 to 1975–76
Summary: During the five years 1971–72 to 1975–76 annual total discharges of patients with a primary diagnosis of asthma from public hospitals in the Hunter Health Region (NSW) fluctuated only slightly. The number of discharges did not reflect consistently the underlying population distribution. Significantly more discharges than expected occurred among people living in the drier inland areas of the Region.
Over the same period 65 residents of the Hunter Health Region were certified dead with asthma as the primary cause. In 29, death occurred at one of the Region's public hospitals but only eight were admitted as hospital inpatients primarily with asthma. Of the 65 asthma deaths, 36 (55.4%) occurred outside the Region's public hospitals. 相似文献
Over the same period 65 residents of the Hunter Health Region were certified dead with asthma as the primary cause. In 29, death occurred at one of the Region's public hospitals but only eight were admitted as hospital inpatients primarily with asthma. Of the 65 asthma deaths, 36 (55.4%) occurred outside the Region's public hospitals. 相似文献
148.
The enthusiasm for performing coronary artery bypass graft (CABG) surgery in Australia is increasing. The results of a number of careful trials which have compared surgical with medical treatment have now appeared. While there is agreement on both the increased survival provided by CABG surgery in those with left main coronary artery stenosis and the relief of symptoms in patients in whom medical therapy has failed to control severe angina, there is debate about the value of surgery in other types of disease. With improvements in medical therapy, the most recent trials have failed to show a significant overall survival benefit from surgery, although it is generally considered that surgery can relieve angina and that, in at least some groups of persons with stenosis of all three main coronary vessels (triple-vessel disease), surgery may prolong life. Alternative methods of prolonging survival among people with ischaemic heart disease include the reduction of risk factors (such as hypertension, raised blood cholesterol levels and cigarette smoking), as well as treating patients with beta-blocking agents after a myocardial infarction. We suggest it is likely that a combination of these approaches could be more effective in terms of lives saved than is CABG and may be less expensive. The current expansion of CABG surgery in Australia should be viewed in this light. 相似文献
149.
150.
Influence of personal and family factors on ventilatory function of children. 总被引:5,自引:1,他引:4
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S R Leeder R T Corkhill M J Wysocki W W Holland 《Journal of epidemiology and community health》1976,30(4):219-224
We wanted to assess the relative influence of various personal and family factors upon the development of ventilatory function in young children. The relationship of several such factors to peak expiratory flow rates measured at the age of five years was studied in 454 children. These children were members of a birth cohort born between 1963 and 1965 in Harrow, north-west London, who were examined regularly from birth through the first five years of life. Beside its expected association with height, peak expiratory flow rate at the age of five years was also related to a lesser extent with peak expiratory flow rate in parents. Children with a history of lower respiratory illness had mean peak flow rates which were lower than those of children who escaped these illnesses. The earlier the onset of the illness and the more frequent its recurrence, the more marked its effect on ventilatory function. The group of children with a history of asthma and bronchitis had the lowest mean peak expiratory flow rate, but a history of bronchitis or pneumonia alone (that is, without asthma) was also associated with reduced ventilatory function. Respiratory illness beginning in the first year of life was the most potentially modifiable determinant of peak expiratory flow rate in children in this study. 相似文献