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111.
Maria Grazia Ruo Redda Chiara De Colle Lavinia Bianco Andrea Ruggieri Daniela Nassisi Annalisa Rossi Eva Gino Claudia Airaldi 《La Radiologia medica》2018,123(6):463-468
Background
Heterotopic ossification (HO) is abnormal formation of lamellar bone in soft tissue; the most frequent causes are total hip arthroplasty and trauma. Severe cases can lead to ankilosis with important impact on quality of life. Surgery is the elective treatment, but, especially in high-risk patients, it is important to prevent the re-formation of HO and, in these cases, radiotherapy (RT) can play an important role.Materials and methods
we retrospectively analyzed a mono-institutional casistic of 30 patients (31 sites) at high risk for HO development, treated with surgery and pre- or postoperative RT. The majority of patients received a single RT fraction of 7 Gy, median age was 62, with a prevalence of male and hip as most frequently involved site. Radiological studies and clinical examination were performed in all patients during the follow-up period to evaluate both treatment efficacy and acute or late toxicity.Results
With a median follow up of 67 months, 23 patients had a complete response (CR) with excellent results in term of joint mobility. Two patients with CR showed a relapse of HO in the same site 19 and 12 months after treatment, respectively. Seven patients (22,6%) had a partial response (PR) to RT. One patient who reached CR had a history of previous irradiation in the same site 16 years before. No acute or late reactions have been reported.Conclusion
Our data confirm safety and efficacy of RT in preventing HO, especially in high-risk patients, preferring a single fraction of 7 Gy.112.
The role of Seprafilm bioresorbable membrane in the prevention and therapy of endometrial synechiae. 总被引:6,自引:0,他引:6
Vassilios S Tsapanos Lavinia P Stathopoulou Vassiliki S Papathanassopoulou Vassilios A Tzingounis 《Journal of biomedical materials research》2002,63(1):10-14
This randomized controlled blind prospective study is undertaken to evaluate the safety and efficacy of Seprafilm--a novel bioresorbable membrane of chemically modified hyaluronic acid and carboxymethylcellulose--in prevention and reduction of postoperative endometrial and endocervical synechiae formation after general suction evacuation or curettage for incomplete, missed, and recurrent abortion. In total, 150 patients with incomplete or missed abortion participated in the clinical study. The study population was divided into two main groups. In the treatment (Seprafilm) group (n=50), application of Seprafilm membrane in the endometrial cavity and the cervical canal was used after the suction evacuation and/or the curettage. In the control group (n=100), nothing was inserted in the uterus. Both groups were divided into two subgroups: patients who had no previous suction or curettage, (with no previous D&C) (n=88), and patients who had at least one previous suction or curettage (with one or more previous D&C) (n=62). In the treatment (Seprafilm) group, 32 patients had no previous D&C and 18 patients had one or more previous D&C. In the control group, 56 patients had no previous D&C and 44 patients had one or more previous D&C. Further fertility was estimated by pregnancy success in all groups. Endometrial synechiae formation was evaluated with the use of hysterosalpingography (HSG) in patients of all groups without pregnancy success 8 months after the intervention. Registering any adverse reaction and performing ultrasound controls assessed the safety of Seprafilm use. From the subgroup with no previous D&C, all 32 patients (100%) who received Seprafilm had a pregnancy in the following 8 months; in the controls, pregnancy occurred only in 54%. It was also demonstrated with hysterosalpingography (HSG) that patients with one or more previous interventions and no pregnancy 8 months later were adhesion free in 90% of the patients where Seprafilm was used, and only 50% in the untreated group. The membrane was tested on the endometrial area of the uterus and did not produce any adverse reaction. Ultrasound controls did not show any abnormal echoes. Intrauterine insertion of Seprafilm is safe, prevents the appearance of endocervical adhesions or endometrial synechiae after curettage, and reduces the area of the endometrial cavity occupied by them in a large percent of cases. It also seems that its use improves the possibility of a new pregnancy and fertility. 相似文献
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Federico Coccolini Fabio Acocella Lavinia Morosi Stefano Brizzola Matteo Ghiringhelli Marco Ceresoli Enrico Davoli Luca Ansaloni Maurizio D’Incalci Massimo Zucchetti 《Pharmaceutical research》2017,34(6):1180-1186
Purpose
Paclitaxel (PTX) is currently used in combination with cisplatin for Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for the treatment of peritoneal carcinomatosis. Albumin-bound PTX is a promising new drug for HIPEC because of its easy solubility in aqueous perfusion medium and possibly because of the tendency of albumin to cross physiological barriers and accumulate in tumor tissue.Methods
We tested the feasibility of using nab-paclitaxel in rabbits treated by HIPEC for 60 min compared with the classical formulation at an equivalent PTX dose. Samples of perfusate and blood were collected at different time points and peritoneal tissues were collected at the end of perfusion. PTX concentrations were determined by HPLC. The depth of paclitaxel penetration through the peritoneal barrier was assessed by mass spectrometry imaging.Results
PTX after nab-paclitaxel treatment penetrated up to 0.63 mm in the peritoneal wall, but after CRE-paclitaxel, it was not detectable in the peritoneum. Moreover, the peritoneal concentration after nab-paclitaxel was five times that after paclitaxel classical formulation. Despite the high levels reached in the peritoneum, systemic exposure of PTX was low.Conclusions
Our results show that nab-paclitaxel penetrates into the abdominal wall better than CRE-paclitaxel, in terms of effective penetration and peritoneal tissue concentration.115.
Areful Islam Md. Saddam Hussain Niloy Sen Fokhrul Abedin Md. Shalahuddin Millat Mohammad Safiqul Islam Abhijit Das Auditi Kar Md. Monir Hossain 《Sustainable Chemistry and Pharmacy》2017
Leucas lavandulifolia, locally called ‘Halkusha or Donkolos’ is a well-known medicinal plant in Bangladesh. The crude methanolic extract of L. lavandulifolia was designed to investigate for its possible chemical groups, thrombolytic, anthelmintic, anxiolytic and antidepressant effects. Thrombolytic and anthelmintic activities were elucidated by taking human erythrocytes and earthworms as test models. The plant extract was divided into two different doses (200 and 400 mg/kg body weight) for evaluating anxiolytic and CNS depressant property on swiss-albino mice by using different test models such as elevated plus maze, hole board, open field and forced Swim tests. The phytochemical analysis of the crude extract revealed the presence of alkaloids, carbohydrates, glycosides, tannins, flavonoids, phytosterols and phenols. In the thrombolytic test, the plant extract had produced dose dependent clot lysis potential in human erythrocytes at five different doses (2, 4, 6, 8, 10 mg/ml), while standard streptokinase and water were used as positive and negative controls. Five different concentrations (10, 20, 30, 40 & 50 mg/ml) of crude extract of L. lavandulifolia also showed marked anthelmintic property in earthworms in a dose dependent manner. Significant (p <0.01; p < 0.05) CNS depressant and anxiolytic activity were observed in case of both extract doses (200 and 400 mg/kg body weight) which were comparable to the standard drug diazepam. Thus, the present study asserted the potentiality of L. lavandulifolia as thrombolytic, anthelmintic, anxiolytic and CNS depressant agents and therefore supports the traditional uses of this medicinal plant. 相似文献
116.
Lavinia Lin Katherine B. Brown Brian J. Hall Fan Yu Jingqi Yang Jason Wang 《Global public health》2016,11(9):1135-1147
Guangzhou is China's third most populous city, and the region's burgeoning manufacturing economy has attracted many young African businessmen and entrepreneurs to the city. The aims of this study were to examine strategies that African migrants in Guangzhou have adopted in response to health-care barriers, and explore their perceptions of how to address their needs. Twenty-five semi-structured interviews and two focus groups were conducted among African migrants residing in Guangzhou, China. Facing multiple barriers to care, African migrants have adopted a number of suboptimal and unsustainable approaches to access health care. These included: using their Chinese friends or partners as interpreters, self-medicating, using personal connections to medical doctors, and travelling to home countries or countries that offer English-speaking doctors for health care. Health-care providers and health organisations in Guangzhou have not yet acquired sufficient cultural competence to address the needs of African migrants residing in the city. Introducing linguistically and culturally competent health-care services in communities concentrated with African migrants may better serve the population. With the growing international migration to China, it is essential to develop sustainable approaches to improving health-care access for international migrants, particularly those who are marginalised. 相似文献
117.
Manuel A.R. Ferreira Judith M. Vonk Hansjörg Baurecht Ingo Marenholz Chao Tian Joshua D. Hoffman Quinta Helmer Annika Tillander Vilhelmina Ullemar Yi Lu Franz Rüschendorf David A. Hinds Norbert Hübner Stephan Weidinger Patrik K.E. Magnusson Eric Jorgenson Lavinia Paternoster 《The Journal of allergy and clinical immunology》2019,143(2):691-699
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