某市青霉素及头孢类抗菌药物皮肤过敏试验现状调查研究

目的调查某市部分医疗机构青霉素类和头孢类抗菌药物皮肤过敏试验(简称皮试)的执行现状,为规范皮试的执行提供参考。方法分层随机抽取10家某市二级以上医疗机构医院,发放调查问卷180份,了解各医疗机构青霉素类和头孢类抗菌药物皮试的执行情况。结果口服剂型是否需皮试、皮试液的配制流程等方面在不同医院、科室和护士间均存在较大差异。结论为了保证患者用药安全,青霉素类和头孢类的皮试相关问题亟待规范。     

银杏叶提取物改善反复脑缺血再灌注小鼠血液流变学的作用

目的：研究银杏叶提取物（ＥＧＢ）改善反复脑缺血再灌注小鼠血液流这的作用。方法：采用反复脑缺血再注模型鼠,应用毛细管微量热沉法和毛细管微量法分别检测血纤维蛋白原含量和红细胞压积数值,并将结果输入全自动血液流变仪得出血浆粘度、血液粘度、血细胞聚集系数,血栓形成系数及微循环滞留时间（ＭＳＴ）。结果：ＥＢＧ２５￣１００ｍｇ／ｋｇ均可不同程度地降低Ｆｉｂ、ＨＣＴ、降低ηｂ、ηｐ、ηｈ,缩小ＶＡＬ及ＴＷＥＬ,     

牛奶蛋白过敏致婴儿食物诱导性小肠结肠炎综合征1例报告

目的探讨牛奶蛋白过敏及牛奶蛋白过敏导致的食物诱导性小肠结肠炎综合征的临床诊断和治疗。方法回顾性分析1例牛奶蛋白过敏导致婴儿食物诱导性小肠结肠炎综合征的临床资料。结果出生67 d女性患儿,出生起即混合喂养,出生后2周起反复腹泻、腹胀、呕吐、黏液血便、喂养困难、贫血和生长发育迟缓。实验室检查见贫血、白细胞总数和C反应蛋白升高、嗜酸性粒细胞比例增高,牛奶特异性Ig E阴性。4次住院及入院时均诊断为"坏死性小肠结肠炎"。经回避牛奶蛋白4周后,症状消失,牛奶蛋白激发试验阳性,符合牛奶蛋白过敏以及牛奶蛋白过敏导致婴儿食物诱导性小肠结肠炎特征。结论牛奶蛋白过敏及牛奶蛋白过敏导致婴儿食物诱导性小肠结肠炎的临床表现非特异性,症状体征多样,临床需注意辨别。     

Evaluation of the Effect of Inactivated Transmissible Gastroenteritis Virus Vaccine with Nano Silicon on the Phenotype and Function of Porcine Dendritic Cells

A transmissible gastroenteritis virus (TGEV) is a porcine enteropathogenic coronavirus, causing acute swine enteric disease especially in suckling piglets. Mesoporous silica nanoparticles (MSNs) are safe vaccine adjuvant, which could enhance immune responses. Our previous research confirmed that nano silicon had immune-enhancing effects with inactivated TGEV vaccine. In this study, we further clarified the immune-enhancing mechanism of the inactivated TGEV vaccine with MSNs on porcine dendritic cells (DCs). Our results indicated that the inactivated TGEV vaccine with MSNs strongly enhanced the activation of the DCs. Expressions of TLR3, TLR5, TLR7, TLR9, and TLR10, cytokines IFN-α, IL-1β, IL-6, IL-12, and TNF-α, cytokine receptor CCR-7 of immature DCs were characterized and showed themselves to be significantly higher in the inactivated TGEV vaccine with the MSN group. In summary, the inactivated TGEV vaccine with MSNs has effects on the phenotype and function of porcine DCs, which helps to better understand the immune-enhancing mechanism.     

Morphological and mechanical properties of biodegradable poly(glycolic acid)/poly(butylene adipate-co-terephthalate) blends with in situ compatibilization

In the present work, the biodegradable blends of poly(glycolic acid) (PGA) and poly(butylene adipate-co-terephthalate) (PBAT) with in situ compatibilization using 4,4′-methylenebis(phenyl isocyanate) (MDI) were prepared. The combined results of FTIR, DSC, SEM, DSC, POM, TGA and rheology demonstrated that the MDI was successfully reacted with PGA/PBAT, the complex viscosity and storage moduli (G′) of the blends were increased. Melt elasticity and viscosity of the blends were also increased on increasing the concentration of PBAT. SEM results indicated that the compatibility was improved by in situ compatibilization. Due to the apparent differences in melting temperature (T_m) between PGA and PBAT, the morphology of the dispersed phase evolved from a spherical structure to in situ microfiber when the content of PBAT was up to 60% during injection molding. The interfacial adhesion between PGA and PBAT was strengthened, consequently, the impact strength of the blend was sharply increased from 9.0 kJ m⁻² to 22.2 kJ m⁻². On account of the chain extension effect, the crystallinity, crystallization temperature and crystallization size were decreased, which was also of benefit for the improvement of toughness. Meanwhile, the thermal stability of the PGA was improved through blending with PBAT. A novel biodegradable blending material with enhanced toughness and thermal stability was prepared.

A novel biodegradable poly(glycolic acid)/poly(butylene adipate-co-terephthalate) (PGA/PBAT) material with enhanced toughness through in situ compatibilization was prepared.     

Structures and impact strength variation of chemically crosslinked high-density polyethylene: effect of crosslinking density

Impact strength of high-density polyethylene (HDPE), especially at low temperature, is crucial for its applications outdoors because of its poor impact strength. In order to improve the impact strength of HDPE, crosslinked HDPE was prepared by the addition of a peroxide crosslink agent, bis(tert-butyldioxyisopropyl)benzenehexane, and the effect of the crosslinking density on the microstructures and mechanical properties, especially impact strength between −60 °C and 23 °C, were investigated. The results show that the crosslinking density is controlled by varying the content of the crosslinking agent. It is found that, at room temperature, with increase in the content of crosslink agent from 0% to 0.5–0.7%, the impact strength increases from 4 kJ m⁻² to about 80 kJ m⁻² and the elongation at break increases from 20% to about 550%. With further increase in the content of crosslink agent to 1.5%, the impact strength and the elongation at break reduce to 64 kJ m⁻² and 360% respectively. With increase in crosslink agent, the flexural modulus, yield strength, crystallinity, mean lamellar thickness, crystal size and spherulitic size and the brittle–ductile transition temperature (BDTT) decrease, and the gel content, impact strength of the HDPE at low temperature, intensity of β transition increase significantly. In considering both the room temperature mechanical properties and low temperature impact strength, the optimized content of the crosslink agent is about 0.7%. Overall, crosslinking significantly improves the toughness and impact strength of HDPE and extends its application, especially at low temperature.

Crosslinking significantly improves the toughness and impact strength of HDPE and extends its application, especially at low temperature.     

内镜下开窗治疗儿童十二指肠重复畸形1例并文献复习

目的探讨儿童十二指肠重复畸形的临床表现及内镜下治疗方案。方法回顾分析1例十二指肠重复畸形患儿的临床资料。结果 13岁男性患儿,反复腹痛4年。血淀粉酶、脂肪酶均升高;腹部CT可见囊性包块。确诊为十二指肠重复畸形。经过内镜下开窗治疗,患儿腹痛消失,随访半年切口愈合良好。结论十二指肠重复畸形是罕见的消化道畸形,在一定条件下,内镜下开窗治疗可作为首选治疗方案。     

葛根芩连丸中多糖类溶出度的测定方法

目的：建立测定葛根芩连丸中多糖类溶出度的方法。方法：溶出度的测定用蒽酮硫酸法显色,紫外可见分光光度法在622nm处测定吸光度。结论：多糖的溶出度在45min内达到了70%的标准。结果：测定葛根芩连丸中多糖溶出度的方法简单,可为葛根芩连丸质量评价的研究提供新的参考指标,也为复方制剂中多糖类的含量测定提供参考。