Sexual behaviour of adult rats after a single neonatal injection of reserpine

To investigate whether reserpine given in the critical period of sexual differentiation of the rat brain affects adult sexual behaviour, female and male rats were given a single injection of reserpine on the fourth day after birth, and their sexual behaviour was tested at maturity. In the 11 consecutive daily tests for spontaneous sexual behaviour the reserpine treated female animals showed fewer regular behavioural and vaginal oestrous cycles than the control animals. 19 % of the reserpinized and none of the control animals had prolonged oestrous behaviour without a coincident prolonged vaginal cycle. The reseptivity quotients of the reserpine treated animals were reduced. In the tests for hormone induced sexual behaviour after ovariectomy no statistically significant differences between the number of animals responding or between the receptivity quotients occurred. The tests for spontaneous sexual behaviour in males showed that the reserpinized animals needed fewer intromissions to ejaculate than the controls. The significance of these findings is discussed.     

Methamphetamine use among marginalized youth in British Columbia

BACKGROUND: Crystal methamphetamine (MA) is a powerful, highly addictive central nervous stimulant that can cause serious health consequences including neurotoxicity, paranoia, psychosis, depression, violence, and death. The objective of this study is to assess the prevalence and characteristics of MA use among two marginalized populations of youth (less than 30 years of age) in British Columbia. METHODS: A self-administered questionnaire was administered to a convenience sample of Vancouver street-involved youth (SY) and Lesbian/Gay/Bisexual/Transgender/Questioning (LGBTQ) centre youth in Vancouver and Victoria. Items measured include: participants' demographic characteristics; illicit substance use, including details of MA use; attempts at recovery and treatment; and potential consequences of MA use. RESULTS: One hundred and eighty of the 200 questionnaires distributed were completed. Sixty-seven percent of the SY and 24% of the LGBTQ youth reported ever having used MA. Of these: 43% had used within the last week; 46-57% used multiple times per day in their lifetime; they spent a maximum of 7-9 consecutive days awake; they began use in their middle to late teens; and half had sought help for a substance use disorder. SY who used MA within the last week were more likely to also use marijuana, cigarettes, heroin, ecstasy, and ketamine. Previous use of MA was associated with reports of auditory hallucinations. CONCLUSION: The current study demonstrates a high prevalence of MA use in two marginalized populations of youth. Use in sexual minorities, resulting psychopathology, and concurrent substance use all have important implications in delivery of service, prevention, and subsequent research.     

抗CD20单抗（Rituximab）作为B细胞淋巴瘤老龄患者初始治疗的新标准

背景侵袭性B细胞淋巴瘤是目前最常见的非霍奇金淋巴瘤类型,主要包括弥漫大B细胞淋巴瘤(DLBCL)和套细胞淋巴瘤(MCL)。超过60%的患者被诊断出B细胞淋巴瘤时年龄都在60岁以上。在过去的30年间,CHOP方案(环磷酰胺、多柔比星、长春新碱、泼尼松)是治疗DLBCL的金标准。年龄较轻的患者