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51.
Lamia Mhadhebi Afef Dellai Audrey Clary‐Laroche Rafik Ben Said Jacques Robert Abderrahman Bouraoui 《Drug development research》2012,73(2):82-89
Strategy, Management and Health Policy | ||||
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Enabling Technology, Genomics, Proteomics | Preclinical Research | Preclinical Development Toxicology, Formulation Drug Delivery, Pharmacokinetics | Clinical Development Phases I‐III Regulatory, Quality, Manufacturing | Postmarketing Phase IV |
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Hans Kromhout Melissa Friesen M Mathilde Marques Consolato Maria Sergi Mohamed Abdallah Geza Benke Mark Cesta Dori Germolec Keith Houck Gaku Ichihara Charles William Jameson Jun Kanno Igor Pogribny Camilla Svendsen Lamia Benbrahim-Tallaa Kathryn Z Guyton Yann Grosse Fatiha El Ghissassi Kurt Straif 《The lancet oncology》2018,19(8):1020-1022
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Abdelkefi A Ladeb S Torjman L Othman TB Lakhal A Romdhane NB Omri HE Elloumi M Belaaj H Jeddi R Aissaouï L Ksouri H Hassen AB Msadek F Saad A Hsaïri M Boukef K Amouri A Louzir H Dellagi K Abdeladhim AB;Tunisian Multiple Myeloma Study Group 《Blood》2008,111(4):1805-1810
From April 2003 to December 2006, 195 patients with de novo symptomatic myeloma and younger than 60 years of age were randomly assigned to receive either tandem transplantation up front (arm A, n = 97) or one autologous stem-cell transplantation followed by a maintenance therapy with thalidomide (day + 90, 100 mg per day during 6 months) (arm B, n = 98). Patients included in arm B received a second transplant at disease progression. In both arms, autologous stem-cell transplantation was preceded by first-line therapy with thalidomide-dexamethasone and subsequent collection of peripheral blood stem cells with high-dose cyclophosphamide (4 g/m(2)) and granulocyte colony stimulating factor. Data were analyzed on an intent-to-treat basis. With a median follow-up of 33 months (range, 6-46 months), the 3-year overall survival was 65% in arm A and 85% in arm B (P = .04). The 3-year progression-free survival was 57% in arm A and 85% in arm B (P = .02). Up-front single autologous transplantation followed by 6 months of maintenance therapy with thalidomide (with second transplant in reserve for relapse or progression) is an effective therapeutic strategy to treat multiple myeloma patients and appears superior to tandem transplant in this setting. This study was registered at www.ClinicalTrials.gov as (NCT 00207805). 相似文献
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Ben Yaghlène L Hammel P Palazzo L Belmatoug N Pauwels A Troalen K O'Toole D Lévy P Ruszniewski P 《Gastroentérologie clinique et biologique》2005,29(3):294-296
We report here a case of acute pancreatitis revealing Behcet's disease in an 18-year-old woman. Pancreatitis was due to ischemia secondary to severe abnormalities of the celiac trunk arteries with pseudo-aneurysms. The outcome was favourable after the administration of corticosteroids and cyclophosphamide. The patient did not experience relapse of pancreatitis 2 years after diagnosis. 相似文献
60.
Kharrat M Tardy V M'Rad R Maazoul F Jemaa LB Refaï M Morel Y Chaabouni H 《The Journal of clinical endocrinology and metabolism》2004,89(1):368-374
Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders mainly due to defects in the steroid 21-hydroxylase (CYP21) gene. To determine the mutational spectrum in the Tunisian CAH population, the CYP21 active gene was analyzed in 51 unrelated patients using our cascade strategy (digestion by restriction enzyme, sequencing). All patients had a classical form of 21-hydroxylase deficiency. Mutations were detected in over 94% of the chromosomes examined. The most frequent mutation in the Tunisian CAH population was found to be Q318X, with large prevalence (35.3%), in contrast to 0.5-13.8% described in other series. Incidence of other mutations does not differ, as previously described: large deletions (19.6%), mutation in intron 2 (17.6%), and I172N (10.8%). Four novel mutations were found in four patients with the salt-wasting form. These four novel mutations include three point mutations that have not been reported to occur in the CYP21P pseudogene: R483W, W19X, 2669insC, and one small conversion of DNA sequence from exon 5 to exon 8. Our results have shown a good genotype/phenotype correlation in the case of most mutations. This is the first report of screening for mutations of 21-hydroxylase gene in the Tunisian population and even in the Arab population. 相似文献