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Hans Kromhout Melissa Friesen M Mathilde Marques Consolato Maria Sergi Mohamed Abdallah Geza Benke Mark Cesta Dori Germolec Keith Houck Gaku Ichihara Charles William Jameson Jun Kanno Igor Pogribny Camilla Svendsen Lamia Benbrahim-Tallaa Kathryn Z Guyton Yann Grosse Fatiha El Ghissassi Kurt Straif 《The lancet oncology》2018,19(8):1020-1022
104.
Yasmin Mounir Tohamey Asmaa Mahmoud Abdel Magied Lamia Adel Salah El Din Reham Ashraf Mohamed 《The Egyptian Journal of Radiology and Nuclear Medicine》2018,49(2):571-578
Aim of work
To assess the added value of MRI compared to US in diagnosis of Mullerian duct anomalies and its subtypes thus guiding proper management plans.Patients and methods
From October 2014 to March 2015 we prospectively evaluated 50 female patients, ranging in age from 15 to 40?years. They were referred for US and MRI assessment of clinically suspected Mullerian duct anomalies.Results
Final diagnosis of patients includes: 8/50 (16%) cases were classified as class I, 10/50 (20%) cases were classified as class II, 22/50 (44%) cases were classified as class III, 5/50 (10%) cases were classified as class IV and 5/50 (10%) cases were not MDA. MRI was superior to US, with reported diagnostic accuracy of 100%.Conclusion
The use of diverse imaging modalities, in conjunction with clinical information, provided important clues to the diagnosis of MDAs. The imaging work-up for MDAs usually begins with ultrasound. Although it might have been suffice to detect the presence of a uterine abnormality, MRI was generally needed to classify the abnormality into a specific MDA category. 相似文献105.
Ahmad Mohamed Wafaie Lamia Medhat Afifi Kareem Mohsen Moussa Ayman Mahmoud Mansour Hoda Magdy Abbas 《The Egyptian Journal of Radiology and Nuclear Medicine》2018,49(4):1068-1075
Purpose
To study the efficacy of diffusion tensor imaging (DTI) in the diagnosis of carpal tunnel syndrome (CTS).Materials and Methods
Twenty-three wrists of healthy subjects (age between 29 and 71 with mean of 44?years) and 47 wrists of CTS patients (age between 19 and 84 with mean of 46?years) were evaluated with DTI and electrophysiological studies (EPS). The DTI was performed on a 1.5T scanner. Fraction anisotropy (FA) and apparent diffusion coefficient (ADC) of the median nerve were calculated. Electrophysiological tests were also performed. Paired student’s t-test, ANOVA, Mann-Whitney, Wilcoxon, Post Hoc, Kruskal-Wallis, Chi-Square, Spearman’s Rho and Pearson statistical tests were used.Results
There was a significant difference between healthy individuals and patients with CTS (P?<?0.01) for both FA and ADC. An FA value of less than 0.54 and an ADC value of more than 1.19?×?10?3?mm2/sec can be used in the diagnosis of CTS. Regarding the results of DTI, the sensitivity, the specificity, the negative predictive value, the positive predictive value and the accuracy were 97.8%, 95.6%, 95.6%, 97.8% and 97.1% respectively.Conclusion
DTI can contribute to CTS diagnosis on the basis of FA and ADC measurements. 相似文献106.
107.
Abdelkefi A Ladeb S Torjman L Othman TB Lakhal A Romdhane NB Omri HE Elloumi M Belaaj H Jeddi R Aissaouï L Ksouri H Hassen AB Msadek F Saad A Hsaïri M Boukef K Amouri A Louzir H Dellagi K Abdeladhim AB;Tunisian Multiple Myeloma Study Group 《Blood》2008,111(4):1805-1810
From April 2003 to December 2006, 195 patients with de novo symptomatic myeloma and younger than 60 years of age were randomly assigned to receive either tandem transplantation up front (arm A, n = 97) or one autologous stem-cell transplantation followed by a maintenance therapy with thalidomide (day + 90, 100 mg per day during 6 months) (arm B, n = 98). Patients included in arm B received a second transplant at disease progression. In both arms, autologous stem-cell transplantation was preceded by first-line therapy with thalidomide-dexamethasone and subsequent collection of peripheral blood stem cells with high-dose cyclophosphamide (4 g/m(2)) and granulocyte colony stimulating factor. Data were analyzed on an intent-to-treat basis. With a median follow-up of 33 months (range, 6-46 months), the 3-year overall survival was 65% in arm A and 85% in arm B (P = .04). The 3-year progression-free survival was 57% in arm A and 85% in arm B (P = .02). Up-front single autologous transplantation followed by 6 months of maintenance therapy with thalidomide (with second transplant in reserve for relapse or progression) is an effective therapeutic strategy to treat multiple myeloma patients and appears superior to tandem transplant in this setting. This study was registered at www.ClinicalTrials.gov as (NCT 00207805). 相似文献
108.
G-protein-coupled receptors (GPCRs) are dynamically regulated by various mechanisms that tune their response to external stimuli. Modulation of their plasma membrane density, via trafficking between subcellular compartments, constitutes an important process in this context. Substantial information has been accumulated on cellular pathways that remove GPCRs from the cell surface for subsequent degradation or recycling. In comparison, much less is known about the mechanisms controlling trafficking of neo-synthesized GPCRs from intracellular compartments to the cell surface. Although GPCR export to the plasma membrane is commonly considered to mostly implicate the default, unregulated secretory pathway, an increasing number of observations indicate that trafficking to the plasma membrane from the endoplasmic reticulum might be tightly regulated and involve specific protein partners. Moreover, a new paradigm is emerging in some cellular contexts, in which stocks of functional receptors retained within intracellular compartments can be rapidly mobilized to the plasma membrane to maintain sustained physiological responsiveness. 相似文献
109.
Lamia?Trabelsi Amira?Mnari Mohamed?M.?Abdel-Daim Salwa?Abid-Essafi Lotfi?AleyaEmail author 《BMC complementary and alternative medicine》2016,16(1):515
Background
In Tunisia, the use of hot spring waters for both health and recreation is a tradition dating back to Roman times. In fact, thermal baths, usually called “Hammam” are recommended as a therapeutic and prophylactic measure against many types of illness and toxicity. While the chemical concentration of thermal water is admittedly associated with its therapeutic effects, the inclusion in spa waters of efficient bioproduct additives produced by photosynthetic microorganisms and that act against oxidative stress may comprise a significant supplementary value for thermal centers. The aim of this study was to investigate the antioxidant potential of the Tunisian thermophilic cyanobacterium Leptolyngbya sp. and to determine its phytochemical constituents and phenolic profile.Methods
BME (Biomass Methanolic Extract), CME (Capsular polysaccharides Methanolic Extract) and RME (Releasing polysaccharides Methanolic Extract) of Leptolyngbya sp. were examined for their antioxidant activities by means of DPPH, hydroxyl radical scavenging and ferrous ion chelating assays. Their total phenols, flavonoids, carotenoids, Mycosporine-like amino acids (MAAs) and vitamin C contents, as well as their phenolic profiles were also determined.Results
BME has the highest content of phenols (139?±?1.2 mg/g), flavonoids (34.9?±?0.32 mg CEQ/g), carotenoids (2.03?±?0.56 mg/g) and vitamin C (15.7?±?1.55 mg/g), while the highest MAAs content (0.42?±?0.03 mg/g) was observed in CME. BME presented both the highest DPPH and hydroxyl radical scavenging ability with an IC50 of 0.07 and 0.38 mg/ml, respectively. The highest ferrous chelating capacity was detected in CME with an IC50?=?0.59 mg/ml. Phenolic profiles revealed the presence of 25 phenolic compounds with the existence of hydroxytyrosol, oleuropein, resveratrol and pinoresinol.Conclusion
The study demonstrated that the cyanobacterium Leptolyngbya sp. possesses abundant natural antioxidant products which may have prophylactic and therapeutic effects on many types of illness and toxicity. The present findings not only explain and reinforce the rationale behind traditional therapeutic practices in Tunisia in the exploitation of the country’s hot springs, but support the addition of Leptolyngbya to thermal waters as a means to enhance the value and reputation of the curative nature of Tunisian thermal waters.110.
Cendrine Cabou Paula Honorato Luis Briceo Lamia Ghezali Thibaut Duparc Marcelo Len Guillaume Combes Laure Frayssinhes Audren Fournel Anne Abot Bernard Masri Nicol Parada Valeria Aguilera Claudio Aguayo Claude Knauf Marcelo Gonzlez Claudia Radojkovic Laurent O. Martinez 《Acta physiologica (Oxford, England)》2019,226(3)