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151.
A Hellström C Jansson M Boguszewski R Olegård L Laegreid K Albertsson-Wikland 《Acta paediatrica (Oslo, Norway : 1992)》1996,85(12):1456-1462
Objective: Prenatal alcohol exposure may cause fetal alcohol syndrome (FAS), which is associated with pre- and postnatal growth retardation. Materials and methods: Spontaneous 24-h growth hormone (GH) secretion was measured in six prepubertal short children with FAS (two boys and four girls) aged 4-14 years. The response to a GH stimulation test, and levels of insulin-like growth factor-I (IGF-1) and IGF-binding protein-3 (IGFBP-3) were also measured. Comparisons were made between the children with FAS and healthy children of both normal and short stature, as well as children born small for gestational age (SGA). Results: There were no differences in the mean area under the curve above the baseline or the maximum level of GH during a 24-h period (GHmax ) between the children with FAS and the reference groups. However, the estimated rate of spontaneous 24-h GH secretion in children with FAS was similar to that of children born SGA, but lower than in children of normal stature ( p = 0.02). The plasma concentrations of IGF-1 and IGFBP-3 were in the lower parts of the normal range. Conclusion: We conclude that GH secretion in short children with FAS is similar to that in short children born SGA; that is, in the lower range of normal children. 相似文献
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A. E. Medvedev A. Laegreid A. Sundan & T. Espevik 《Scandinavian journal of immunology》1996,43(4):439-448
In the present study the authors elucidated the involvement of the two TNF receptors (TNFR) in discriminating TNF and lymphotoxin-α (LT-α) effects in human SW480-βGal and KYM-1 cell lines. A non-competitive p55 TNFR monoclonal antibody (MoAb) 44E strongly enhanced LT-α-mediated gene regulation and cytotoxicity up to the level of the responses caused by TNF. TNF-induced biological responses were only weakly influenced by 44E. 44E did not affect both binding and the rate of dissociation of the cytokines. The combination of the two p55 TNFR MoAb 44E and Htr5 elicited strong TNF responses, while none of them were agonistic alone. When the p75 TNFR was blocked with Utr1, LT-α was still less potent than TNF in mediating CMV promoter activation and cytotoxicity. However, the addition of 44E in the presence of Utr1 merged the LT-α dose-response curves with those obtained with TNF plus Utr1. Using antagonistic TNFR MoAb, the authors further showed that TNF functions through both TNFR types while LT-α mediates its effects largely via the p55 TNFR. These data suggest that LT-α is less potent than TNF due to its lower ability to properly trigger the p55 TNFR and because of its lack of signalling through the p75 TNFR. 相似文献
154.
An oral lesion of sickle cell disease resembling a rapidly growing vascular lesion filled with sickled red cells is presented. 相似文献
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联苯双酯制剂的物理分散状态及体外释放度 总被引:2,自引:1,他引:1
用X-射线衍射法,考察不同载体制备的固体分散体系中联笨双酯的物理分散状态,聚乙二醇6000(PEG 6000)固体分散系为有限互溶固体溶液,聚乙烯吡咯烷酮(PVP)共沉淀物为无定形粉末,脲共熔物为简单低共熔混合物,热分析研究亦证实PEG 6000固体分散物较其相应比例的物理混合物及片剂有更高的分散度。比较两种联苯双酯片剂与滴丸的体外释放度,两种片剂的释放度参数td值分别为37和178min,滴丸未包衣者为11min,包衣者为26.in。由此可知物理分散状态是影响释放速度的主要因素。 相似文献
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