Efficacy of novel hypoxic cell sensitiser doranidazole in the treatment of locally advanced pancreatic cancer: long-term results of a placebo-controlled randomised study.

Novel hypoxic cell radiosensitiser doranidazole was tested for unresectable pancreatic cancer administered at intraoperative radiotherapy. Short-term survival was not different. However, difference has been observed concerning 3-year survival (doranidazole group vs. placebo; 23% vs. 0%, p=0.0192). This sensitiser might be effective in improving long-term survival for pancreatic cancer.     

Vertebrobasilar insufficiency: stable xenon computed tomography-cerebral blood flow study in posterior circulation revascularization

Preoperative and postoperative local cerebral blood flow were measured by the stable xenon computed tomography-cerebral blood flow technique in 15 patients with vertebrobasilar insufficiency. The surgery included end-arterectomy or angioplasty of the vertebral artery (five cases), superficial temporal artery-superior cerebellar artery anastomosis (eight cases), and superficial temporal artery-posterior cerebral artery anastomosis (two cases). Fourteen (93.3%) of the 15 patients improved in the post-operative period. Low local cerebral blood flow in the ischemic area without infarction manifested a constant and significant increase postoperatively. In summary, the stable xenon computed tomography-cerebral blood flow technique is thought to be a simple and useful method for assessing local cerebral blood flow in posterior circulation perioperatively.     

Intracerebral arteriovenous malformation fed by the anterior ethmoidal artery: case report

The authors report a case of intracerebral arteriovenous malformation fed by the anterior ethmoidal artery. The nidus was located in the brain parenchyma, although its feeder was a dural artery. The etiology of this rare condition is discussed.     

Cervical Infarction Associated with Vertebral Artery Occlusion due to Spondylotic Degeneration: Case Report

Summary  Cases of cervical infarction with clearly documented evidence of the underlying aetiology and associated neuroradiological abnormalities have not been frequently reported. A rare case of cervical infarction caused by midvertebral artery occlusion due to spondylotic degeneration of the spine is described. The most probable aetiological factor affecting this disease entity, and the usefulness of magnetic resonance imaging in the detection of this rare lesion, are briefly discussed.     

Multiple Subpial Transection (MST) for the Control of Seizures That Originated in Unresectable Cortical Foci

Abstract: Multiple subpial transection (MST) was applied to 12 cases with intractable epilepsy, the foci of which were located in unresectable essential areas. The result proved that MST is effective in controlling seizures, and no explicit neurological deficits have incurred postoperatively.     

Localized hepatic necrosis related to cytomegalovirus and Toxoplasma gondii

An unusual hepatic lesion due to both cytomegalovirus and Toxoplasma gondii was described in a patient with angio-immunoblastic lymphadenopathy treated by predonin. The lesion was a single well-defined area measuring 1.5 x 1.0 x 0.5 cm of confluent severe hepatic necrosis with multiple cytomegalic inclusion cells and numerous tokoplasmas. The remaining liver had no liver cell necrosis, inflammatory cell infiltration, or evidence of either cytomegalovirus infection or toxoplasmosis. These findings suggested us the possibility of symbiosis and synergism of cytomegalovirus and toxoplasma gondii in the liver. Additionally, this was the first demonstration of cytomegalovirus in liver cells by electron microscopy.