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排序方式: 共有277条查询结果,搜索用时 15 毫秒
91.
Anastase Dzudie Simeon-Pierre Choukem Félicité Kamdem Solange Doualla Henry A Joko Marielle EE Lobe Yves M Mbouende Henry Luma Abdoul K Adam Andre P Kengne Patricia Gouking Mesmin Dehayem Jean-Claude Mbanya Samuel Kingue 《Cardiovascular journal of Africa》2012,23(10):533-537
Aim
This study assessed the prevalence and determinants of electrocardiographic abnormalities in a group of type 2 diabetes patients recruited from two referral centres in Cameroon.Methods
A total of 420 patients (49% men) receiving chronic diabetes care at the Douala General and Yaoundé Central hospitals were included. Electrocardiographic abnormalities were investigated, identified and related to potential determinants, with logistic regressions.Results
The mean age and median duration of diagnosis were 56.7 years and four years, respectively. The main electrocardiographic aberrations (prevalence %) were: T-wave abnormalities (20.9%), Cornell product left ventricular hypertrophy (16.4%), arrhythmia (16.2%), ischaemic heart disease (13.6%), conduction defects (11.9%), QTc prolongation (10.2%) and ectopic beats (4.8%). Blood pressure variables were consistently associated with all electrocardiographic abnormalities. Diabetes-specific factors were associated with some abnormalities only.Conclusions
Electrocardiographic aberrations in this population were dominated by repolarisation, conduction defects and left ventricular hypertrophy, and were more related to blood pressure than diabetes-specific factors. 相似文献92.
Acute pulmonary embolism: ancillary findings at spiral CT 总被引:28,自引:1,他引:27
93.
94.
A. Radouane F. Péhourcq G. Tramu EE Creppy and B. Bannwarth 《Fundamental & clinical pharmacology》1996,10(3):309-313
Summary— The aim of this quantitative structure-activity relationship (QSAR) study was to investigate the influence of lipophilicity on the diffusion of cephalosporins into the cerebrospinal fluid (CSF). The lipophilicity was expressed as the chromatographic capacity factor (log k'w ) determined by high-performance liquid chromatography in a reversed-phase system. The penetration of eight cephalosporins into CSF was studied in male Wistar rats receiving the drugs intramuscularly (1.5 mg/kg). One hour after administration, CSF and blood samples were collected, and concentrations of free drug were measured in CSF (CCSF ) and in plasma (CP ). A significant parabolic relationship was sought between lipophilicity (log k'w ) and the capacity of diffusion across the blood-brain barrier expressed as log (CCSF /CP ). The cephalosporins exhibiting a moderate lipophilicity diffused well into CSF. A pharmacokinetic study was performed at 1, 2 and 4 h after administration of three cephalosporins: cefazolin, ceftriaxone and cefsulodin. These compounds were choosen according to their lipophilicities (low, moderate and high values, respectively). The AUC0–4h for both free plasma (AUCP ) and cerebrospinal fluid (AUCCSF ) concentrations were determined. The AUCCSF /AUCP ratio presented a maximum value for a strongly albumin bound cephalosporin, ceftriaxone. In our experimental conditions, the ideal lipophilicity (log k'w ) range for diffusion of cephalosporins from plasma into CSF was between 1.6 and 1.8. 相似文献
95.
Helicobacter pylori gastritis: radiographic findings 总被引:2,自引:0,他引:2
Sohn J; Levine MS; Furth EE; Laufer I; Rubesin SE; Herlinger H; Lichtenstein GR 《Radiology》1995,195(3):763
96.
New bone formation in the peripheral skeleton was detected radiographically in 67% (22/33) of patients studied for new periarticular pain among 72 patients with osteoporosis being treated with fluoride, 66-88 mg/d, for 6 or more months. Changes included periosteal and endosteal new bone formation as well as trabecular thickening and were localized in areas of high mechanical stress. Sufficient mineral deposition for radiographic detection required 6 or more months of fluoride treatment. Radiologists must differentiate fluoride-induced new bone formation from other-processes, such as fractures and tumor, and elicit information on fluoride intake in suspicious cases. 相似文献
97.
Summary The course and determinants of insulin action were investigated in 8 newly diagnosed Type 1 (insulin-dependent) diabetic patients, who were studied every 3 months for one year, and in three groups of 8 patients each with 5, 10 and 20 years diabetes, studied once. Fifteen healthy subjects matched for age, sex and body weight served as control subjects. Dose-response curves were constructed using sequential euglycaemic (5.0 mmol/l) clamps (insulin infusion rates: 0.5, 1.0, 2.0 and 5.0 mU·kg–1·min–1 in periods of 2h). After 1/2 month of insulin treatment, insulin responsiveness was normal, but sensitivity was decreased (ED50 70±7 mU/l (SEM) vs 54±4mU/l in control subjects, p<0.05). After 6 months, insulin sensitivity was improved (ED50 57±4 mU/l, p<0.01 vs 1/2 month and not significant (NS) vs control subjects); but after 9 and 12 months, it was reduced again, similarly to 0.5 month. Insulin responsiveness remained normal at all time-points. In the three groups of patients with longstanding diabetes, impaired insulin sensitivity with normal responsiveness was noted also (ED50 73±9 mU/l, p<0.02 vs control subjects). At 6, 9 and 12 months, glycaemic control (HbA1) and insulin dose were inverse correlates for insulin action; in patients with longstanding disease, this was noted for HbA1 and body weight, in control subjects for body weight. In conclusion, decreased insulin sensitivity re-develops in Type 1 diabetes within the first year following an initial improvement. Presumably, hyperglycaemia plays a role in the pathogenesis of this recurrence. 相似文献
98.
Vitamin D: metabolism, and effects on growth and development 总被引:1,自引:0,他引:1
EE Delvin 《Acta paediatrica (Oslo, Norway : 1992)》1994,83(S405):105-110
99.
DK Lewis RPH Peters MJ Schijffelen GRF Joaki AL Walsh JG Kublin J Kumwenda S Kampondeni ME Molyneux EE Zijlstra 《Malawi medical journal : the journal of Medical Association of Malawi》2003,15(2):56-60
The aims of the study were to measure the prevalence and outcome of mycobacteraemia in febrile hospitalised adults; to determine what proportion could be identified using routine methods; to assess clinical indicators of mycobacteraemia and the usefulness of a diagnostic trial of anti-TB treatment. We prospectively examined adults with fever or a history of fever admitted to adult medical wards of QECH, Blantyre. All had blood cultured for bacteria and mycobacteria, chest x-ray and sputum smears. M. tuberculosis was the commonest blood isolate, affecting 57 of 344 patients (17%). In 44 (77%) patients with mycobacteraemia, TB was identified using routine investigations; in only 6 (11%) it was not suspected. Strong clinical indicators of mycobacteraemia were anaemia, HIV seropositivity, cough, chronic fever, and a clinical diagnosis of AIDS on the day of admission. Of nine patients selected for a therapeutic trial of TB treatment, six had mycobacteraemia, of whom five died during the trial. Mortality on short course chemotherapy on the TB ward after one month, was similar whether patients had mycobacteramia (21%) or not (32%). TB can be identified with routine methods in most patients with mycobacteraemia. If treated, mycobacteraemia has as good an early outcome as TB without mycobacteraemia. Strengthening of basic facilities is likely to improve detection and treatment of mycobacterial disease. 相似文献
100.
Vertebral bone density in children: effect of puberty 总被引:12,自引:0,他引:12
Gilsanz V; Gibbens DT; Roe TF; Carlson M; Senac MO; Boechat MI; Huang HK; Schulz EE; Libanati CR; Cann CC 《Radiology》1988,166(3):847-850
To determine changes in bone density during growth, trabecular vertebral density and an index of spinal cortical bone were measured with quantitative computed tomography in 101 children. The children were divided by age into three groups: prepubertal, indeterminate, and pubertal. Compared with prepubertal children, pubertal adolescents had significantly higher trabecular bone density and more compact bone in the spine (P less than .001). After controlling for puberty, vertebral bone density failed to correlate significantly with age, sex, weight, height, surface area, and body mass index. The results indicate that bone density increases markedly during puberty. 相似文献