Unusual computed tomography appearances of acute cholangitis

This case describes some unusual computed tomography findings in a patient with an acute ascending cholangitis and pancreatitis due to a calculus impacted in the distal common bile duct.     

The midaortic syndrome: diagnosis and treatment

The midaortic syndrome is an unusual entity seen in children and adolescents. It is characterized by severe narrowing of the abdominal aorta with progressive involvement of the renal and visceral branches. Eleven patients (aged 5 months to 15 years) suspected of having midaortic syndrome were examined preoperatively and postoperatively. All patients had hypertension and were examined with midstream aortography. All aortograms showed a smooth, segmental stenosis of the abdominal aorta and severe bilateral proximal renal artery stenosis. In three patients, percutaneous transluminal angioplasty of the renal artery was attempted, two preoperatively and one for a postoperative stricture. None showed long-term success, presumably due to the progressive nature of the disease. Grafts were surgically placed in ten patients and produced successful results in nine.     

Photochemotherapy of vascular cells with 8-methoxypsoralen and visible light: differential effects on endothelial and smooth muscle cells

BACKGROUND: The long-term efficacy of percutaneous transluminal coronary angioplasty is limited by the restenosis which occurs in approximately 40% of patients, usually within 6 months of the procedure. PURPOSE: The present study was designed to evaluate the effects of 8-methoxypsoralen (8-MOP) activated with visible light on the properties of bovine aortic smooth muscle cells (SMC) and endothelial cells (EC) in vitro. METHODS: Cells were seeded in polystyrene wells, allowed to attach over a 24-h period, incubated with 1, 20, or 50 microg/ml 8-MOP and then exposed to 12 J/cm2 visible light (447 nm). Cell counts were performed for up 14 days (n = 4-6 wells per time point), and each experiment was performed in triplicate. Cellular migration, morphology, and size were also analyzed. RESULTS: The lowest 8-MOP dose (1 microg/ml) had no significant effect on SMC proliferation, while the highest dose (50 microg/ml) induced cytostasis. An intermediate dose of 8-MOP (20 microg/ml) produced a transient and reversible inhibition of proliferation. There was no significant effect on proliferation of EC at lowest dose of 8-MOP (1 microg/ml). However, in contrast to the SMC experiments, a transient and reversible inhibition of EC proliferation was seen at both 20 and 50 microg/ml 8-MOP. CONCLUSIONS: These experiments demonstrate that while 8-MOP photoactivated with 447 nm visible light can reversibly inhibit the proliferation of both SMC and EC in a dose-dependent fashion, SMC are more sensitive to the treatment than EC.     

Getting out of Procrustes' bed: The needs and benefits of qualitative research in stuttering

Qualitative research has a vast potential for understanding complex issues such as stuttering, and is becoming more common in that research field. The purpose of this article is to highlight the potential benefits of qualitative research in stuttering through exploration of four different research paradigms and their knowledge claims. Through this explanation, a case is built for the benefits of applying qualitative methods to stuttering research. Questions such as “how” a certain behavior or process take places, rather than just “if” a certain behavior or process takes place, are possible within the qualitative paradigm. It is concluded that future knowledge about stuttering and its treatment will be well served by applying the most appropriate investigative methods to it rather than by attempting to establish information with a restricted set of quantitative approaches.