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51.
女性常见的妇科疾病如子宫内膜异位症、子宫内膜癌、乳腺癌、Sheehan综合征等,其病程中体内雌激素水平变化,直接或间接地影响骨转换水平,导致骨量变化。本文研究不同疾病状态下,疾病本身因素或手术及药物治疗对女性卵巢功能和雌激素水平的影响,从而影响骨转换率,导致继发性骨质疏松。有助于预防和治疗女性激素相关性骨量下降和骨质疏松,提高女性患者的生活质量。 相似文献
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LN Barlow-Mosha DS Bagenda PK Mudiope MC Mubiru LM Butler MG Fowler PM Musoke 《African health sciences》2012,12(3):249-258
Background
Access to pediatric antiretroviral formulations is increasing in resource-limited countries, however adult FDCs are still commonly used by antiretroviral therapy (ART) programs.Objective
To describe long-term effectiveness of using adult FDC of d4T+3TC+NVP (Triomune) in children for HIV treatment.Methods
Clinical, immunologic, and virologic outcomes of HIV-infected ART-naïve children aged six months to 12 years, were evaluated up to 96 weeks post-ART initiation.Results
From March 2004 to June 2006, 104 children were followed with a median age of 5.4 years, median CD4 cell percent and HIV-1 RNA were 11.0% (IQR 6.7–13.9) and 348,846copies/mL (IQR 160,941–681,313) respectively at baseline. Using Kaplan-Meir estimates, 75% of children had undetectable viral loads (<400copies/mL) at 96weeks of ART. Children with a baseline CD4 cell percent >15% were 3 times more likely to achieve viral load <400copies/mL than those with baseline CD4 cell percent <5% after adjusting for baseline age {aHR = 3.03 (1.10–8.32), p=0.03}; no difference was found among those with CD4 cell percent >5–14.9% and <5%.Conclusion
Treatment with generic adult FDC for HIV-infected Ugandan children led to sustained clinical, immunologic and virologic response during 96 weeks of ART. Early initiation of ART is key to achieving virological success. 相似文献54.
目的探讨退行性腰椎侧凸(degenerativelumbarscoliosis,DIS)与骨质疏松症(osteoporosis,OP)两者之间的关系。方法选取2006年6月-2010年6月来我院就诊的DIS患者58例及对照组(非腰椎侧凸的腰痛患者)58例,对DIS组Cobb’s角进行测量,并采用双能x线吸收法检测两组患者腰椎(k~L4)、股骨颈、股骨粗隆和Ward’s三角区骨密度T值,分析患者年龄、Cobb’s角与骨密度T值的相关性。结果DIS组平均骨密度T值为-2.7±1.8,合并OP45例,发病率为77.59%;对照组平均骨密度T值为-1.3±1.0,合并OP8例,发病率为13.79%,两组比较有显著性差异(P〈0.05)。相关分析显示,DIS患者T值与年龄呈正相关(r=-0.318,P〈0.01),与侧凸Cobb’s角无关。结论OP是DLS发病的危险因素,同时年龄越大OP程度越重,但与DLS进展程度无关。临床DLS治疗时要考虑到OP的影响。 相似文献
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Associations between unprocessed red and processed meat,poultry, seafood and egg intake and the risk of prostate cancer: A pooled analysis of 15 prospective cohort studies
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Kana Wu Donna Spiegelman Tao Hou Demetrius Albanes Naomi E. Allen Sonja I. Berndt Piet A. van den Brandt Graham G. Giles Edward Giovannucci R. Alexandra Goldbohm Gary G. Goodman Phyllis J. Goodman Niclas Håkansson Manami Inoue Timothy J. Key Laurence N. Kolonel Satu Männistö Marjorie L. McCullough Marian L. Neuhouser Yikyung Park Elizabeth A. Platz Jeannette M. Schenk Rashmi Sinha Meir J. Stampfer Victoria L. Stevens Shoichiro Tsugane Kala Visvanathan Lynne R. Wilkens Alicja Wolk Regina G. Ziegler Stephanie A. Smith‐Warner 《International journal of cancer. Journal international du cancer》2016,138(10):2368-2382
Reports relating meat intake to prostate cancer risk are inconsistent. Associations between these dietary factors and prostate cancer were examined in a consortium of 15 cohort studies. During follow‐up, 52,683 incident prostate cancer cases, including 4,924 advanced cases, were identified among 842,149 men. Cox proportional hazard models were used to calculate study‐specific relative risks (RR) and then pooled using random effects models. Results do not support a substantial effect of total red, unprocessed red and processed meat for all prostate cancer outcomes, except for a modest positive association for tumors identified as advanced stage at diagnosis (advanced(r)). For seafood, no substantial effect was observed for prostate cancer regardless of stage or grade. Poultry intake was inversely associated with risk of advanced and fatal cancers (pooled multivariable RR [MVRR], 95% confidence interval, comparing ≥45 vs. <5 g/day: advanced 0.83, 0.70–0.99; trend test p value 0.29), fatal, 0.69, 0.59–0.82, trend test p value 0.16). Participants who ate ≥25 versus <5 g/day of eggs (1 egg ~ 50 g) had a significant 14% increased risk of advanced and fatal cancers (advanced 1.14, 1.01–1.28, trend test p value 0.01; fatal 1.14, 1.00–1.30, trend test p value 0.01). When associations were analyzed separately by geographical region (North America vs. other continents), positive associations between unprocessed red meat and egg intake, and inverse associations between poultry intake and advanced, advanced(r) and fatal cancers were limited to North American studies. However, differences were only statistically significant for eggs. Observed differences in associations by geographical region warrant further investigation. 相似文献
57.
Campa D Kaaks R Le Marchand L Haiman CA Travis RC Berg CD Buring JE Chanock SJ Diver WR Dostal L Fournier A Hankinson SE Henderson BE Hoover RN Isaacs C Johansson M Kolonel LN Kraft P Lee IM McCarty CA Overvad K Panico S Peeters PH Riboli E Sanchez MJ Schumacher FR Skeie G Stram DO Thun MJ Trichopoulos D Zhang S Ziegler RG Hunter DJ Lindström S Canzian F 《Journal of the National Cancer Institute》2011,103(16):1252-1263
58.
Chen F Stram DO Le Marchand L Monroe KR Kolonel LN Henderson BE Haiman CA 《European journal of human genetics : EJHG》2011,19(2):243-245
Genome-wide association studies (GWAS) have identified common variants associated with breast cancer risk among women of European and Asian ancestries. To assess the generalizability across ethnic/racial populations of a risk score derived from genotyping 12 highly replicated breast cancer GWAS hits, we performed a case-control study (2224 cases and 2827 controls) nested in the Multiethnic Cohort (MEC) study, which was initiated in 1993-1996 and consists of subjects mainly from European-American, African-American, Native Hawaiian, Japanese and Latino populations. When viewed as a summary risk score, the total number of risk alleles carried by women was significantly associated with breast cancer risk overall (OR per allele, 1.09; 95% CI, 1.06-1.12; P=2.0 × 10(-10)) and in all populations except African-Americans, in which no significant association was observed (OR, 1.03; 95% CI, 0.98-1.08). In aggregate, the number of risk alleles is strongly associated with breast cancer risk in all populations studied except African-Americans. These results emphasize the need for large-scale association studies of multiple racial/ethnic groups for discovery and characterization of risk alleles relevant to all populations in the United States. 相似文献
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