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G Murialdo S Fonzi P Costelli GP Solinas C Parodi S Marabini M Fanciullacci A Polleri 《Cephalalgia : an international journal of headache》1994,14(3):205-209
Nocturnal urinary melatonin excretion was significantly decreased throughout an ovarian cycle in 12 migraine without aura patients compared to 8 healthy controls. Normal increases in urinary melatonin excretion during the luteal phase was less pronounced in the migraine patients. Melatonin excretion was further decreased during headache. The data indicate impaired pineal function in migraine. 相似文献
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Based on the cost computations for automatic and manual processes of the film development the conditions for useful operations of automatic developing machines are derived. The analysis is given to the problem of an adequate supply of X-ray photolaboratories with necessary equipment and staff. 相似文献
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Dea Grip Riboe MBBS Tilde Steen Dogan MBBS John Brodersen MD GP PhD 《Journal of evaluation in clinical practice》2013,19(2):311-316
Background Colorectal cancer (CRC) is one of the most common types of cancer in European countries and associated with a high mortality rate. A 16% relative risk reduction (RRR) of mortality was found in a meta‐analysis based on four randomized controlled trials (RCT) on CRC screening. The aim of this paper was to scrutinize these trials for potential biases and assess their influence on the screening trials. Methods The four RCTs were reviewed based on the principles of ‘Critical Appraisal of the Medical Literature’. Principal investigators of the four RCTs were contacted to clarify uncertainties in their study. Data were collected from The Danish Data Archives. Authors of the Cochrane review were contacted. Results Six biases were identified, of which five favour screening. Three of the biases identified were specific to CRC screening: type of diagnostic method, place of surgery and diagnostic delay. Conclusion The 16% RRR in CRC mortality found in the updated Cochrane review's meta‐analysis is overestimated. 相似文献
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Viktorova TV Kochetova OV Safina KF Gaĭnullina MK Akhmadishina LZ Korytina GF 《Gigiena i sanitariia》2011,(6):54-57
The paper gives the basic results of studying the polymorphic loci of the genes of xenobiotic transformation enzymes, antioxidative defense, and DNA repair in petrochemical workers. Polymerase chain reaction-restriction fragment length polymorphism assay was used to identify markers of the predisposition to the development of toxic hepatitis in men and impaired reproduction in women. 相似文献