全文获取类型
收费全文 | 18741篇 |
免费 | 864篇 |
国内免费 | 100篇 |
专业分类
耳鼻咽喉 | 133篇 |
儿科学 | 329篇 |
妇产科学 | 260篇 |
基础医学 | 2563篇 |
口腔科学 | 741篇 |
临床医学 | 1212篇 |
内科学 | 4417篇 |
皮肤病学 | 355篇 |
神经病学 | 1366篇 |
特种医学 | 985篇 |
外科学 | 3170篇 |
综合类 | 79篇 |
一般理论 | 1篇 |
预防医学 | 577篇 |
眼科学 | 304篇 |
药学 | 1160篇 |
中国医学 | 21篇 |
肿瘤学 | 2032篇 |
出版年
2023年 | 86篇 |
2022年 | 165篇 |
2021年 | 319篇 |
2020年 | 152篇 |
2019年 | 182篇 |
2018年 | 311篇 |
2017年 | 233篇 |
2016年 | 320篇 |
2015年 | 314篇 |
2014年 | 402篇 |
2013年 | 488篇 |
2012年 | 861篇 |
2011年 | 939篇 |
2010年 | 486篇 |
2009年 | 456篇 |
2008年 | 864篇 |
2007年 | 924篇 |
2006年 | 955篇 |
2005年 | 1023篇 |
2004年 | 1003篇 |
2003年 | 1018篇 |
2002年 | 1021篇 |
2001年 | 495篇 |
2000年 | 510篇 |
1999年 | 539篇 |
1998年 | 303篇 |
1997年 | 262篇 |
1996年 | 232篇 |
1995年 | 187篇 |
1994年 | 218篇 |
1993年 | 195篇 |
1992年 | 399篇 |
1991年 | 381篇 |
1990年 | 347篇 |
1989年 | 324篇 |
1988年 | 356篇 |
1987年 | 303篇 |
1986年 | 265篇 |
1985年 | 252篇 |
1984年 | 197篇 |
1983年 | 124篇 |
1982年 | 87篇 |
1981年 | 90篇 |
1980年 | 88篇 |
1979年 | 142篇 |
1978年 | 95篇 |
1977年 | 79篇 |
1976年 | 84篇 |
1975年 | 75篇 |
1973年 | 65篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
991.
Yasunori Natsuda Hiroyuki Kuwano Takahiro Ezaki Keizo Sugimachi Kiyoshi Inokuchi 《Surgery today》1983,13(4):354-357
A forty year-old Japanese woman complained of slight hematemesis and severe pain on swallowing. Fluoroscopical examination showed typical esophagograms of “double barreled esophagus” or “mucosal stripe”. An esophageal ulceration, probably where the dissection reentered the usual lumen, was endoscopically evident at the lower end of the mucosal bulging. A large, shallow ulcer of unknown cause was also identified in the just anal area from the esophago-gastric junction. She recovered with conservative treatment of fasting, cimetidine and sodium alginate. 相似文献
992.
993.
994.
Mitsutoshi Yamamoto M.D. Shigeru Takahashi M.D. Saburo Otsuki M.D. Toshiaki Kugoh M.D. Kiyoshi Hosokawa M.D. Norio Ogawa M.D. 《Psychiatry and clinical neurosciences》1985,39(4):515-519
Abstract: The lumbar cerebrospinal fluid (CSF) γ-aminobutyric acid (GABA) levels were measured in 27 patients with epilepsy, another three epileptic patients with status epilepticus and three epileptic patients with chronic cerebellar ataxia. The mean lumbar CSF GABA levels of the 27 patients with epilepsy were not significantly different from those of normal controls. Six of these 27 patients who had daily partial complex and partial motor seizures showed significantly low CSF GABA levels as did the six other patients, three each with status epilepticus and chronic cerebellar ataxia. These findings suggest that some epileptic patients have impaired brain GABAergic neurons. 相似文献
995.
Hisamatsu K Inoue H Makiyama K Homma M 《The Annals of otology, rhinology, and laryngology》2005,114(10):804-808
OBJECTIVES: Our purpose was to investigate mucosal cell injury due to the nitric oxide (NO)-superoxide system in otitis media with effusion. METHODS: We determined the levels of nitrotyrosine (NT) and NO and the activities of superoxide dismutase (SOD) and lactic dehydrogenase (LDH) in 90 middle ear fluid samples. RESULTS: The NT concentration was significantly higher in group A (<16 years old) than in group C (>50 years old; p < .05), and significantly higher in the acute group than in the chronic group (p < .05). The NO concentration did not show a significant difference among the groups. The activity of SOD showed significant correlations with the concentrations of NT and NO and with LDH activity (p < .05). The LDH activity was significantly greater in group A than in group C (p < .05). CONCLUSIONS: Our results indicate involvement of the NO-superoxide system in the pathogenesis of otitis media with effusion, showing evidence of protein and/or cell injury in the middle ear. 相似文献
996.
This report describes a vasculitis and subsequently developing angiodestructive lymphoma in an 11-year-old Japanese-Filipino girl exhibiting mosquito allergy with the background of chronic active Epstein-Barr virus (EBV) infection. She developed necrotic skin ulcer at the site of mosquito bite, and histopathological examination revealed EBV-positive mononuclear cell infiltration throughout the wall of small-sized muscular artery. These EBV-positive lymphoid cells were oligoclonal in Southern blot analysis for EBV terminal repeats. Effectiveness of steroid therapy also supports the nonneoplastic nature. Approximately 1 year later, she developed progressive large skin ulcer without mosquito bites. Microscopically, the angiocentric or angiodestructive pattern of EBV-positive atypical cells supported the diagnosis of extranodal natural killer/T-cell lymphoma. Southern blot analysis revealed the monoclonal neoplastic nature of EBV-positive cells. In contrast to the primary mosquito bite lesion, natural killer/T-cell lymphoma cells exhibited the higher expression of EBV latent membrane protein 1 mRNA and the apparent protein expression detected by immunohistochemistry. 相似文献
997.
Ghrelin is a gut-brain peptide and its endocrine activities are mediated by GH secretagogue receptor (GHSR)-1a. Des-acyl ghrelin does not activate GHSR-1a and is devoid of endocrine activities. While the microinjection of ghrelin into rat nucleus tractus solitarii (NTS) elicited hypotensive effects, this was not the case upon injection into GHSR-expressing rostral ventrolateral medulla or caudal ventrolateral medulla. To make clear the reason of the discrepancy between receptor distribution and neuronal responses, we examined the cardiovascular response of rats microinjected with des-acyl ghrelin into NTS. Intra-NTS injection of des-acyl ghrelin significantly reduced mean arterial pressure and heart rate. The hypotensive and bradycardic activity evoked by des-acyl ghrelin was not significantly different from that of native ghrelin. These results suggest that des-acyl ghrelin contribute to the regulation of cardiovascular control and that a receptor other than GHSR-1a exists in NTS. 相似文献
998.
Projections to the alimentary canal from the dopaminergic neurons in the dorsal motor nucleus of the vagus of the rat 总被引:3,自引:0,他引:3
Tsukamoto K Hayakawa T Maeda S Tanaka K Seki M Yamamura T 《Autonomic neuroscience : basic & clinical》2005,123(1-2):12-18
The motility of the alimentary canal is regulated not only by neurons that contain acetylcholine or adrenaline, but also by nonadrenergic noncholinergic neurons. There are many neurons containing dopamine in the dorsal motor nucleus of the vagus (DMV). We examined the projections of these dopaminergic neurons to the alimentary canal with double-labeling immunohistochemistry for tyrosine hydroxylase (TH) and the retrograde tracer cholera toxin subunit b following its injection into the subdiaphragmatic esophagus, the cardia, the pylorus, the duodenum, the jejunum, and the ascending colon. Almost all double-labeled neurons were found in the half of the DMV caudal to the area postrema. In the caudal half of the DMV, about 58% of the TH-immunoreactive neurons projected to the cardia, about 36% projected to the pylorus, and about 28% projected to the subdiaphragmatic esophagus. Only a few TH-immunoreactive neurons projected to the duodenum, the jejunum, or the ascending colon. As a whole, less than 10% of the neurons in the DMV that projected to the alimentary canal showed TH-like immunoreactivity. These results suggest that some of the dopaminergic neurons in the DMV might regulate the activities of the stomach and the subdiaphragmatic esophagus. 相似文献
999.
Total correction was performed in a case of complete transposition of the great arteries (TGA) with severe pulmonary vascular obstructive disease (PVOD). Although severe pulmonary hypertension remained after surgery, oxygenation was continued for 15 months, which included a shift to at-home oxygen inhalation therapy (HOT). Cardiac catheterization 15 months after surgery demonstrated that pulmonary hypertension was greatly improved. For patients in whom the palliative Mustard operation is considered due to severe PVOD on the basis of lung biopsy diagnosis, total correction of TGA is possible by employing HOT after surgery. 相似文献
1000.
Abe J Hosokawa H Okazawa M Kandachi M Sawada Y Yamanaka K Matsumura K Kobayashi S 《Brain research. Molecular brain research》2005,136(1-2):91-98
TRPM8 is a TRP family cation channel which can be activated by cold stimuli or l-menthol. However, TRPM8 protein localization of nerve terminals in sensory organs remains unknown. Here we generated an antibody against TRPM8 and analyzed TRPM8 protein localization in trigeminal ganglia (TG) and in sensory nerve fibers in the tongue. TRPM8 immunoreactivity was detected in a subset of neurons with a small diameter in TG and in nerve fibers in the tongue. TRPM8-immunoreactive nerve fibers were rich in fungiform papillae, but sparse in foliate and circumvallate papillae. The TRPM8-immunoreactive nerve fibers reached the outer epithelial layer in each papilla, while no TRPM8-immunoreactive nerve fibers penetrated into taste buds. Double labeling analysis revealed that TRPM8 immunoreactivity was co-expressed with a part of TRPV1 or CGRP-immunoreactive neurons in TG. However, TRPM8 immunoreactivity was not observed in TRPV1- or CGRP-positive nerve fibers in fungiform, foliate, and circumvallate papillae. These results suggest that TRPM8 protein is present in sensory lingual nerve fibers mainly projected from TG and might work as cold and l-menthol receptors on tongue. 相似文献