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排序方式: 共有394条查询结果,搜索用时 15 毫秒
211.
Scrotal calculi: sonographic detection 总被引:2,自引:0,他引:2
212.
213.
Background
To investigate the effects of intravenous lignocaine infusions (IV lignocaine) in fibromyalgia.Methods
Prospective study of the adverse effects of IV lignocaine in 106 patients with fibromyalgia; retrospective questionnaire study of the efficacy of IV lignocaine in 50 patients with fibromyalgia.Results
Prospective study: Two major (pulmonary oedema and supraventricular tachycardia) and 42 minor side-effects were reported. None had long-term sequelae. The commonest was hypotension (17 cases). Retrospective study: Pain and a range of psychosocial measures (on single 11-point scales) improved significantly after treatment. There was no effect of the treatment on work status. The average duration of pain relief after the 6-day course of treatment was 11.5 ± 6.5 weeks.Conclusions
Intravenous lignocaine appears to be both safe and of benefit in improving pain and quality of life for patients with fibromyalgia. This needs to be confirmed in prospective randomised controlled trials.214.
Altered gap junctional intercellular communication in neoplastic rat esophageal epithelial cells 总被引:2,自引:1,他引:2
Gap junctional intercellular communication (GJIC) is reduced in many
neoplastic cells, but few data exist for esophageal neoplasms. GJIC was
examined by fluorescent dye microinjection in two nontumorigenic and two
highly tumorigenic rat esophageal epithelial cell lines. All lines
expressed high levels of dye coupling in homologous cell culture. In
cocultures of nontumorigenic and tumorigenic cells, however, only one of
six cell combinations displayed significant heterologous GJIC. Northern,
Western, and immunohistochemical analyses indicated that all four cell
lines expressed comparable levels of connexin43 (Cx43), but not connexin32
or connexin26, and formed Cx43-containing gap junction plaques at cell-cell
interfaces. Immunostaining of rat esophageal frozen sections demonstrated
that esophageal epithelial cells expressed Cx43 in vivo. In normal
epithelium, the highest expression was seen in the basal cells and little
suprabasal staining was evident. In preneoplastic and neoplastic lesions of
the esophageal epithelium which were induced by treating rats with
N-nitrosomethylbenzylamine, Cx43 staining of the basal layer was also seen
but appeared to be more diffuse compared to normal epithelium. In addition,
suprabasal Cx43 staining was apparent in dysplastic and papillomatous
lesions. These results indicate that Cx43 is expressed in normal and
neoplastic rat esophageal cells and that the cells exhibit extensive
homologous GJIC, but little heterologous GJIC. This lack of heterologous
GJIC may be due to differences in cell adhesion proteins or other factors.
相似文献
215.
JH Cross GD Jackson BG Neville A Connelly FJ Kirkham SG Boyd MC Pitt DG Gadian 《Archives of disease in childhood》1993,69(1):104-109
The incidence of brain abnormalities determined by magnetic resonance in 30 consecutive children presenting with intractable complex partial seizures is reported. Images were optimised to visualise the hippocampus and cortical grey matter. Abnormalities of the hippocampus or temporal lobe were seen in all 19 children with clinical features of temporal lobe epilepsy and in six of the seven children with clinically unlocalised epilepsy. By contrast, in the four children with a clinical diagnosis of extratemporal epilepsy, no temporal or hippocampal abnormalities were seen. Generalised cortical abnormalities of uncertain significance were found in a total of 14 children from all groups. The identification of focal brain abnormalities using optimised magnetic resonance imaging enables early non-invasive assessment of children with intractable seizure disorders and the identification of patients for whom epilepsy surgery may be appropriate. It may also lead to a better understanding of the structural basis of intractable epilepsy, and thereby contribute to early treatment decisions. 相似文献
216.
Antimalarial activity of Tanzanian medicinal plants 总被引:2,自引:0,他引:2
Tanzanian medicinal plants were extracted and tested for in vitro antimalarial activity, using the multidrug resistant K1 strain of Plasmodium falciparum. Of 49 plants investigated, extracts of three plants were found to have an IC50 between 5-10 micrograms/ml, extracts of 18 other plants showed an IC50 between 10 and 50 micrograms/ml, all others were less active. The three most active extracts were obtained from the tubers of Cyperus rotundus L. (Cyperaceae), the rootbark of Hoslundia opposita Vahl. (Labiatae), and the rootbark of Lantana camara L. (Verbenaceae). 相似文献
217.
I-compounds are endogenous bulky DNA modifications which are detected by
nuclease P1-enhanced 32P-post-labeling in tissue DNA of animals not
knowingly exposed to carcinogens. Their profiles and levels depend inter
alia on animal age, species, strain, tissue, gender, diet and exposure to
chemicals such as cytochrome P450 inducers and carcinogens. Due to lack of
sufficient material obtainable from in vivo sources, chemical structures of
I-compounds and their parent normal bases have not yet been identified. In
this report we provide 32P-post-labeling and chromatographic evidence that
two prominent I-compounds, herein called C1 and C2, which occur at
relatively high levels in pig liver DNA are guanine derivatives. This
result was obtained by showing that both compounds, isolated from
32P-post-labeling thin-layer maps, were chemically unstable, i.e. they
could be readily hydrolyzed to 32P-post- labeled deoxyguanosine
3',5'-bisphosphate by heating in water. C1 appeared particularly labile,
undergoing hydrolysis during thin-layer chromatography at pH 3.3 without
heating. Several other I-compounds and adducts, as well as the four normal
DNA nucleotides, were, however, highly resistant to hydrolysis under the
conditions used here. The possible significance of these findings will be
briefly discussed.
相似文献
218.
219.
220.
Computed tomography in lead encephalopathy: a case report 总被引:2,自引:0,他引:2