探索灰色文献

在概述了灰色文献的起源、内涵、外延及其他特征的基础上,对各国学者对灰色文献的研究进行了比较分析,对灰色文献的自身价值和社会作用进行了分析评价.     

阿昔洛韦片剂和胶囊在人体的生物利用度

10名男性受试者按交叉实验设计口服阿昔洛韦片剂和胶囊各400 mg 后,用改良的 HPLC 测定血药浓度,计算表明阿昔洛韦胶囊口服后吸收快于片剂,峰浓度也较高,但吸收程度(AUC_(0-12h))相似。     

流式细胞光度术在鼻咽癌上皮样细胞株细胞周期动力学研究中的应用

本实验应用流式细胞光度术研究鼻咽癌上皮样细胞株（ＣＮＥ）的细胞周期动力学。结果发现ＣＮＥ细胞仍保持原代细胞的ＤＮＡ含量水平（超三倍体和亚四倍体），随着细胞接种时间的延长细胞周期中Ｇ０／Ｇ１时相细胞的百分数逐渐升高，而Ｓ％和Ｇ２＋Ｍ％则逐渐降低。该项研究还发现随着孵育时间的延长，细胞周期中各时相细胞的运动均逐渐延缓，其中以Ｇ０／Ｇ１和Ｇ２＋Ｍ时相细胞的运动减慢较为明显。     

腹部外科感染主要病原菌及药物敏感性的变化趋势

尽管越来越多强有力的新型抗生素应用于临床,感染依然是外科面临的重大难题之一.由于宿主、微生物和抗菌药物三方面各自力量的消长和相互间关系的变动,腹部外科感染性疾病常见细菌的构成比和药物敏感性均处于不断变化的过程中,只有及时掌握这种变化趋势,才能针对性地选用最有效的抗菌药物进行治疗,从而降低术后感染并发症、减少住院时间、减轻病人的经济负担和提高治愈率.     

Clinical and demographic factors associated with DSM-IV melancholic depression.

BACKGROUND: The purpose of this paper is to use demographic and clinical data from a large diverse group of outpatients diagnosed with non-psychotic major depression to investigate the validity of the DSM-IV concept of melancholic depression. METHODS: Baseline clinical and demographic data were collected on 1500 outpatients (1456 of whom melancholia could be determined) with non-psychotic major depressive disorder (MDD) participating in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study. Depressive symptom severity was assessed by clinical telephone interview using the 17-item Hamilton Rating Scale for Depression (HRS-D17) and the 30-item Inventory of Depressive Symptomatology (IDS-C30). The types and degrees of concurrent psychiatric symptoms were measured using a self report, the Psychiatric Diagnostic Screening Questionnaire (PDSQ), by recording the number of items relevant to each diagnostic category endorsed by study participants. RESULTS: Adjusting for severity of depression (as measured by the total HRS-D17 scores), no differences were found in the rate of melancholic depression by race, marital status, education, employment status, family history of depression, primary care versus specialty care, monthly income, and degree of psychiatric and medical co-morbidity. Melancholic depression was significantly more likely in men than women. Melancholic depression after adjustment for severity was associated with a slightly younger age at study entry, as well as with greater illness severity, and slightly shorter duration of current episode. Hispanic ethnicity was associated with lower melancholic depression rates at the .06 level of significance. CONCLUSIONS: Among outpatients with MDD, melancholic features were less likely in Hispanic patients, but more likely in slightly younger patients and in men. Melancholic features were also related to a slightly shorter current episode. These findings are consistent with the notion that external socio-demographic factors do not play an important role in the pathophysiology of melancholic depression.     

Bilateral Duane syndrome and bilateral aniridia.

Duane retraction syndrome has been reported in association with structural abnormalities of the eye, including epibulbar dermoid, keratoconus, iris dysplasia, heterochromia iridis, persistent fetal vasculature, cataract, choroidal coloboma, microphthalmia, and optic nerve dysplasia. A novel association, that of bilateral Duane syndrome with bilateral aniridia, is the subject of this report.     

伽玛刀治疗听神经瘤(附98例分析)

目的 评价伽玛刀治疗听神经的效果。方法 应用OUR旋转式伽玛刀治疗听神经98例。肿瘤直径512～29．7min．平均18.8mm。采用多个放射中心联合照射，周边等剂量曲线为45％-70％，边缘剂量10-13Gy。结果 81例获14。84个月随访，平均39个月。MRI示41例（50．6％）肿瘤缩小，38例（46.9％）无变化，2例（2．5％）增大；25例（30.9％）肿瘤中心失增强。无面瘫和面部麻木，听力保留率59.2％。结论 伽玛刀对听神经瘤有较高的肿瘤控制率，并能保留有用听力，对面神经、三又神经损伤小，是小至中等大小听神经瘤可供选择的治疗方法，及术后残余和复发肿瘤的重要辅助治疗手段。     

背根神经节内P物质、降钙素基因相关肽免疫阳性神经元与阴茎包皮系带感觉信息的传递

目的：探讨背根神经节（DRG）内P物质（SP）、降钙素基因相关肽（CGRP）免疫阳性神经元与阴茎包皮系带感觉信息传递之问的关系。方法：通过荧光金（FG）逆行标记对大鼠阴茎包皮系带内神经末梢的来源作追踪定位，并结合SP、CGRP免疫荧光标记法，研究大鼠DRG内FG标记阳性神经元中SP、CGRP免疫阳性神经元的形态和分布。结果：FG逆行标记结果发现，大鼠阴茎包皮系带内的神经末梢起源于第6腰髓对应的背根神经节（L6-DRG）和第1骶髓对应的背根神经节（S1-DRG）的神经元。对这些神经元分别作SP、CGRP免疫荧光标记后发现，标记细胞大小不等，分别呈深红色和深绿色，沿神经束成行排列或散在分布。FG／SP、FG／CGRP双标记阳性细胞均为中小型，其数量分别占FG逆行标记阳性细胞总数的1／3和1／2，FG／SP／CGRP三标记阳性细胞占FG逆行标记阳性细胞总数的1／5。结论：大鼠L6-DRG和S1-DRG内的SP、CGRP免疫阳性神经元可能参与阴茎包皮系带感觉信息的传递。