全文获取类型
收费全文 | 6129篇 |
免费 | 313篇 |
国内免费 | 44篇 |
专业分类
耳鼻咽喉 | 68篇 |
儿科学 | 244篇 |
妇产科学 | 232篇 |
基础医学 | 597篇 |
口腔科学 | 249篇 |
临床医学 | 543篇 |
内科学 | 1313篇 |
皮肤病学 | 150篇 |
神经病学 | 383篇 |
特种医学 | 122篇 |
外国民族医学 | 2篇 |
外科学 | 834篇 |
综合类 | 269篇 |
一般理论 | 19篇 |
预防医学 | 408篇 |
眼科学 | 150篇 |
药学 | 494篇 |
中国医学 | 89篇 |
肿瘤学 | 320篇 |
出版年
2024年 | 5篇 |
2023年 | 57篇 |
2022年 | 187篇 |
2021年 | 284篇 |
2020年 | 144篇 |
2019年 | 200篇 |
2018年 | 238篇 |
2017年 | 128篇 |
2016年 | 162篇 |
2015年 | 223篇 |
2014年 | 251篇 |
2013年 | 307篇 |
2012年 | 452篇 |
2011年 | 538篇 |
2010年 | 279篇 |
2009年 | 255篇 |
2008年 | 383篇 |
2007年 | 351篇 |
2006年 | 369篇 |
2005年 | 304篇 |
2004年 | 299篇 |
2003年 | 247篇 |
2002年 | 257篇 |
2001年 | 57篇 |
2000年 | 35篇 |
1999年 | 51篇 |
1998年 | 40篇 |
1997年 | 30篇 |
1996年 | 34篇 |
1995年 | 20篇 |
1994年 | 26篇 |
1993年 | 21篇 |
1992年 | 20篇 |
1991年 | 23篇 |
1990年 | 19篇 |
1989年 | 24篇 |
1988年 | 12篇 |
1987年 | 10篇 |
1986年 | 17篇 |
1985年 | 9篇 |
1984年 | 10篇 |
1983年 | 16篇 |
1982年 | 16篇 |
1981年 | 12篇 |
1980年 | 9篇 |
1979年 | 11篇 |
1978年 | 11篇 |
1977年 | 6篇 |
1976年 | 15篇 |
1974年 | 4篇 |
排序方式: 共有6486条查询结果,搜索用时 0 毫秒
61.
Mara Koelker Khalid Alkhatib Logan Briggs Muhieddine Labban Christian P. Meyer Christina M. Dieli-Conwright Dong-Woo Kang Graeme Steele Mark A. Preston Timothy N. Clinton Steve L. Chang Adam S. Kibel Quoc-Dien Trinh Matthew Mossanen 《Canadian Urological Association journal》2023,17(1):E8
IntroductionThere is a scarcity of data on the impact of behavioral habits, such as exercise, on physical health in patients with bladder cancer. We investigated the association of exercise on self-reported physical health status and examined the prevalence of bladder cancer patients with sedentary lifestyle.MethodsWe examined cross-sectional data of participants diagnosed with bladder cancer within the Behavioral Risk Factor Surveillance System (BRFSS) from 2016–2020. Patient health status was surveyed using self-reported measures, such as the total days per month when their “physical health is not good.” The primary outcome was patient-reported poor physical health for more than 14 days within a one-month period.ResultsOut of 2 193 981 survey participants, we identified 936 with a history of bladder cancer. Nearly one in three bladder cancer patients reported being sedentary within the last month, as a total of 307 (32.8%) patients reported no exercise within the last 30 days. The remaining 628 (67.2%) reported exercising for at least one day within the last month. In multivariable logistic regression model analysis, we found that exercise is protective for self-reported poor physical health status (odds ratio 0.37, 95% confidence interval 0.25–0.56, p<0.001). Patients that exercised were less likely to report bad physical health.ConclusionsApproximately one in three bladder cancer patients report no exercise within 30 days, suggesting a sedentary lifestyle. Patients that are active are less likely to self-report poor physical health status. Implementation of exercise programs for bladder cancer patients could be promising in improving health status.KEY MESSAGES
- Approximately 1 in 3 bladder cancer patients report a sedentary lifestyle.
- Patients that are active are less likely to self-report poor physical health status.
- Implementation of exercise programs might improve health status.
- Clinicians of bladder cancer patients should engage in increasing activity levels.
62.
63.
Mashael Binhasan Abdulilah H. Solimanie Khalid S. Almuammar Ahmed R. Alnajres Mai M. Alhamdan Khold Al Ahdal Yasser F. Alfaawaz Khalid Ali Fahim Vohra Tariq Abduljabbar 《Materials》2022,15(12)
The aim of the present study was to evaluate the effect of brushing with two whitening dentifrices (Colgate Optic White (COW) and Colgate Optic White Charcoal (COC)) on surface gloss, micro-roughness, and micro-hardness of nanostructured hybrid conventional (Z350) and bulk-fill (Tetric N Ceram bulk-fill) polymer composite. In total, 96 disk samples using two nano-hybrid composite polymers (Z350 and Tetric N Ceram Bulk-fill) were prepared. All specimens were exposed to two different dentifrices (COW and COC), resulting in four main subgroups in the study. Specimens were assessed for surface gloss, micro-roughness (Ra), and micro-hardness using standardized methodology. Means and standard deviations of properties compared using paired t-test, one-way and two-way ANOVA, and post hoc test. The presence of dentifrices did not show any significant difference in micro-hardness values of Z350 (p > 0.05), whereas micro-hardness of bulk-fill composite significantly reduced on dentifrices exposure (p ≤ 0.05). Bulk-fill polymer composite showed significant reduction in gloss after dentifrice exposure (p < 0.05), however, Z350 showed no significant loss of gloss due to dentifrices (p > 0.05). A significant increase in Ra was observed for both resin materials after exposure to dentifrices (COC and COW). Conventional resin composite (Z350) showed comparable surface hardness and gloss before and after dentifrice exposure, however, micro-roughness increased significantly due to dentifrice exposure. Bulk-fill resin (Tetric N Ceram) showed significant loss of micro-hardness and gloss and increase in micro-roughness on dentifrice exposure. Conventional nano-hybrid composite polymer showed better durability in resisting loss of surface properties compared to bulk-fill resin polymer in the present experiment. 相似文献
64.
Azza R. Maarouf Abdelbasset A. Farahat Khalid B. Selim Hassan M. Eisa 《Medicinal chemistry research》2012,21(6):703-710
A novel series of 1,3,5-triazine analogs was successfully synthesized through conjugation with benzimidazole or 1,2,4-triazole
derivatives via a methylenethio linker. The new analogs were in vitro evaluated against HSV-1 in Vero cells; among these analogs,
two compounds exhibited good effect in inhibiting HSV-1 replication (for compound 5p: EC50 = 3.5 μg/ml, SI = 358; for compound 5r: EC50 = 5.0 μg/ml, SI = 300) in comparison to acyclovir. 相似文献
65.
66.
Atlantis Russ Anh B. Hua William R. Montfort Bushra Rahman Irbaz Bin Riaz Muhammad Umar Khalid Jennifer S. Carew Steffan T. Nawrocki Daniel Persky Faiz Anwer 《Blood reviews》2018,32(6):480-489
Hematological malignancies express high levels of CD47 as a mechanism of immune evasion. CD47-SIRPα triggers a cascade of events that inhibit phagocytosis. Preclinical research supports several models of antibody-mediated blockade of CD47-SIRPα resulting in cell death signaling, phagocytosis of cells bearing stress signals, and priming of tumor-specific T cell responses. Four different antibody molecules designed to target the CD47-SIRPα interaction in malignancy are currently being studied in clinical trials: Hu5F9-G4, CC-90002, TTI-621, and ALX-148. Hu5F9-G4, a humanized anti-CD47 blocking antibody is currently being studied in four different Phase I trials. These studies may lay the groundwork for therapeutic bispecific antibodies. Bispecific antibody (CD20-CD47SL) fusion of anti-CD20 (Rituximab) and anti-CD47 also demonstrated a synergistic effect against lymphoma in preclinical models. This review summarizes the large body of preclinical evidence and emerging clinical data supporting the use of antibodies designed to target the CD47-SIRPα interaction in leukemia, lymphoma and multiple myeloma. 相似文献
67.
68.
Transcranial Doppler: Does Addition of Blood to Agitated Saline Affect Sensitivity for Detecting Cardiac Right‐to‐Left Shunt? 下载免费PDF全文
Mohammad Khalid Mojadidi M.D. Lili Zhang M.D. Yashasvi Chugh M.D. Parham Eshtehardi M.D. F.A.H.A. Ninel Hovnanians M.D. Rubine Gevorgyan M.D. Sanaullah Mojaddedi B.S. Nariman Nezami M.D. Muhammad Omer Zaman M.D. Asim Rafique M.D. Pedro A. Villablanca M.D. M.Sc. Jonathan M. Tobis M.D. F.A.C.C. 《Echocardiography (Mount Kisco, N.Y.)》2016,33(8):1219-1227
69.
Purpose
To report the initial misdiagnosis of patients with Vogt–Koyanagi–Harada (VKH) disease.Methods
The medical records of 76 consecutive patients diagnosed with VKH disease were reviewed retrospectively at The Eye Center, Riyadh, Saudi Arabia. Patients were referred to The Eye Center from Saudi Arabia and other Middle Eastern countries. The initial diagnosis was made by an ophthalmologist or neurologist. The main outcome measure was to evaluate cases with VKH disease who were initially misdiagnosed.Results
In 7 (9.2%) out of the 76 patients the initial diagnosis was incorrect. Patients were initially misdiagnosed as optic neuritis (1.3%), intracranial hypertension (1.3%), brain tumor (1.3%), Susac disease (1.3%), migraine (1.3%), rhegmatogenous retinal detachment (1.3%) or anterior granulomatous uveitis of unknown etiology (1.3%). Patients underwent unnecessary tests including MRI and invasive procedures including CSF analysis and anterior chamber paracentesis.Conclusion
The initial diagnosis of patients with VKH disease was incorrect in 9 % of the cases. Delay in the diagnosis of VKH disease may lead to delay in management and may cause irreversible damage to the photoreceptors with poor visual outcome. 相似文献70.
Majed S. Alamri Intsar S. Waked Fatma M. Amin Khalid W. Al-quliti Mohammad D. Manzar 《Neurosciences (Riyadh, Saudi Arabia)》2019,24(2):81
Objectives:To evaluate the effectiveness of an early mobility protocol for stroke patients in the intensive care unit.Methods:Participants were patients with first or recurrent stroke (n=60, age=49.02±6.36 years, body mass index=32.95±5.67 kg/m2) admitted to the intensive care stroke unit in general hospitals, Riyadh during October and December 2016. Single group pretest-posttest design involving an early mobility protocol was started within first 24 hours admission. Pre and post measurements of muscle strength, pulmonary function and quality of life were carried out.Results:There were significant improvements in muscle strength of upper and lower extremities´ muscles after treatment (p<0.05), pulmonary functions including Forced Vital Capacity, Forced Expiratory Volume 1 (p<0.05) and quality of life, namely, Barthel Index and modified Rankin Scale (p<0.01).Conclusion:This study demonstrates that initiating an early mobility protocol is safe and effective for intensive care unit stroke patients and supports introducing the current protocol as a standard protocol in neurogenic Intensive Care Units.Stroke is a life-threatening condition caused by interruption of the blood supply to any part of the brain. Stroke causes acute neurological disorders and long-term disabilities and imposes economic, social and health impacts on individuals and their families.1 Survivors of stroke are left with mental and physical disabilities that cause social and economic burdens and impair quality of life (QOL). In Saudi Arabia stroke is becoming a rapidly increasing problem and a primary cause of morbidity and mortality.2 Worldwide the incidence of first-time stroke was 17 million during 1990-2000.3 Cerebrovascular diseases including stroke is a leading cause of mortality,4 and stroke is the fifth leading cause of death, but it remains the first cause of disability in the USA.5 By 2030 there will be almost 12 million stroke deaths and 70 million stroke survivors globally.6 Stroke has an adverse influence on the QOL of patients. The onset of stroke is sudden, and unlike other disabling conditions, it leaves patients and their family’s ill prepared for its sequelae.7 Stroke may create unique conditions that affect the patients’ QOL, involving dysfunctions in physical, emotional, memory, thinking, and social interactions.8Stroke is an urgent health care issue. It is a common cause of the hospital admissions. Immediate admission to the neuro-intensive care unit can facilitate early stroke treatment strategies.9 Stroke patients in the intensive care unit (ICU) experience a decrease in physical activity that represents a significant stress on the body and leads to a considerable decrease in functional status, increases morbidity, mortality rate, and duration of hospital stay and cost of care.10 In addition to comorbid diseases, patients on mechanical ventilation have many barriers to mobility because they are surrounded by tubes, catheters, life support and monitoring equipment. Additionally, other factors besides weakness, such as sleep loss, lack of social communication, nutritional status, sedation, and an ICU culture that encourages bed rest further contribute to functional deterioration.11 There is considerable loss of the muscle mass during the initial weeks of immobility in the ICU, therefore its management is inherently related to QOL after discharge.12 Considerable published evidence indicates that patients in ICUs have high morbidity and mortality, high costs of care and a marked decline in functional status.13,14Early and progressive mobilization program has been described as a key component for patients in the ICU. It may decrease post stroke complications such as infections, deep venous thrombosis, pneumonia, pressure ulcers, falls and de-conditioning with bed rest.15 It has been recognized that mobilization of post stroke patients is essential to prevent hospital-associated complications, functional decline and facilitate recovery.16 Moreover, the benefits of early mobilization include decreased ICU-acquired weakness, improved functional recovery within hospital,17 Effective stroke intervention begins the day the patient has a stroke.18 It has a positive effect on patient functional ability, promotes positive psychological effects and improves walking at hospital discharge and reduces hospital length of stay.19 While on the other hand, long term inactivity may affect the patients’ physical, social, emotional, behavioral, and psychological pattern.20 In addition, secondary changes associated with stroke-related inactivity include muscle atrophy, a shift in muscle fiber type to a greater predominance of fast-fatigable, insulin-resistant fibers, loss of cardiovascular fitness, and increased intramuscular fat.21 Therefore, early mobilization program which is a complex intervention that needs crucial patient assessment and management, as well as interdisciplinary team collaboration and training.22,23 The early mobilization may improve patient outcomes and recovery.24 Few studies have investigated the role of increased mobility in ICU patients. Therefore, this prospective intervention trial evaluated the effectiveness of an early mobility program administered by physical therapists and nursing personnel for stroke patients admitted in ICU. 相似文献