全文获取类型
收费全文 | 34444篇 |
免费 | 2310篇 |
国内免费 | 99篇 |
专业分类
耳鼻咽喉 | 497篇 |
儿科学 | 911篇 |
妇产科学 | 482篇 |
基础医学 | 4160篇 |
口腔科学 | 453篇 |
临床医学 | 3740篇 |
内科学 | 7057篇 |
皮肤病学 | 426篇 |
神经病学 | 3024篇 |
特种医学 | 1373篇 |
外科学 | 5752篇 |
综合类 | 405篇 |
一般理论 | 41篇 |
预防医学 | 3090篇 |
眼科学 | 522篇 |
药学 | 2568篇 |
中国医学 | 31篇 |
肿瘤学 | 2321篇 |
出版年
2024年 | 19篇 |
2023年 | 225篇 |
2022年 | 464篇 |
2021年 | 1090篇 |
2020年 | 640篇 |
2019年 | 982篇 |
2018年 | 1175篇 |
2017年 | 816篇 |
2016年 | 826篇 |
2015年 | 988篇 |
2014年 | 1484篇 |
2013年 | 1951篇 |
2012年 | 2817篇 |
2011年 | 2879篇 |
2010年 | 1508篇 |
2009年 | 1401篇 |
2008年 | 2409篇 |
2007年 | 2352篇 |
2006年 | 2166篇 |
2005年 | 2191篇 |
2004年 | 2060篇 |
2003年 | 1837篇 |
2002年 | 1701篇 |
2001年 | 199篇 |
2000年 | 182篇 |
1999年 | 232篇 |
1998年 | 326篇 |
1997年 | 249篇 |
1996年 | 241篇 |
1995年 | 173篇 |
1994年 | 171篇 |
1993年 | 145篇 |
1992年 | 96篇 |
1991年 | 82篇 |
1990年 | 73篇 |
1989年 | 67篇 |
1988年 | 64篇 |
1987年 | 47篇 |
1986年 | 40篇 |
1985年 | 45篇 |
1984年 | 55篇 |
1983年 | 59篇 |
1982年 | 69篇 |
1981年 | 48篇 |
1980年 | 33篇 |
1979年 | 25篇 |
1978年 | 20篇 |
1977年 | 23篇 |
1976年 | 15篇 |
1975年 | 13篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
61.
62.
Kevin G Becker Insong J Lee James W Nagle Rachel D Canning Ameer M Gado Rosarelis Torres Mihael H Polymeropoulos Paul T Massa WilliamE Biddison Paul D Drew 《International journal of developmental neuroscience》1997,15(7):73
We describe a novel human zinc finger cNDA, C2H2-171. This cDNA represents an mRNA which encodes a protein of 484 amino acids and a calculated molecular weight of 54 kD. Four zinc finger-like domains are found in the C-terminal end of the protein. At the N-terminus, C2H2-171 contains a POZ/tramtrack-like domain similar to that found in the tumor associated zinc finger proteins LAZ-3/BCL-6 and PLZ-F, as well as in non-zinc finger proteins. C2H2-171 RNA is preferentially expressed in the brain, and increases during the course of murine development, with maximal expression in the adult. C2H2-171 RNA is differentially expressed in brain regions, with the highest level of expression in the cerebellum. C2H2-171 RNA was expressed at high levels in primary cerebellar granule cell neurons compared to astrocytes. The gene encoding C2H2-171 is highly conserved in vertebrates, and maps to the terminus of human chromosome 1 (1q44-ter). This chromosomal location is associated with a number of cytogenetic aberrations including those involving brain developmental anomalies and tumorigenesis. These data suggest that C2H2-171 may play an important role in vertebrate brain development and function. 相似文献
63.
Benign intracranial hypertension and recombinant growth hormone therapy in Australia and New Zealand
PA Crock JD McKenzie AM Nicoll NJ Howard W Cutfield LK Shield G Byrne 《Acta paediatrica (Oslo, Norway : 1992)》1998,87(4):381-386
Benign intracranial hypertension (BIH) is reported in three children from Australia and one from New Zealand, who were being treated with recombinant human growth hormone (rhGH). Three males and one female, aged between 10.5 and 14.2 y, developed intracranial hypertension within 2 weeks to 3 months of starting treatment. A national database, OZGROW, has been prospectively collecting data on all 3332 children treated with rhGH in Australia and New Zealand from January 1986 to 1996. The incidence of BIH in children treated with growth hormone (GH) is small, 1.2 per 1000 cases overall, but appears to be greater with biochemical GHD (<10IUml -1 ), i.e. 6.5/1000 (3 in 465 cases), relative risk 18.4, 95% confidence interval 1.9-176.1, than in all other children on the database. The incidence in patients with Turner's syndrome was 2.3/1000 (1 in 428 cases). No cases in patients with partial GHD (10–20 IUml -1 ) or chronic renal failure were identified. Possible causative mechanisms are discussed. The authors'practice is now to start GH replacement at less than the usual recommended dose of 14IUm-2 week-1 in those children considered to be at high risk of developing BIH. Ophthalmological evaluation is recommended for children before and during the first few months following commencement of rhGH therapy and is mandatory in the event of peripheral or facial oedema, persistent headaches, vomiting or visual symptoms. The absence of papilledema does not exclude the diagnosis. 相似文献
64.
Canadian Journal of Anesthesia/Journal canadien d'anesthésie - 相似文献
65.
Christina M Marra Clare L Maxwell Ann C Collier Kevin R Robertson Allison Imrie 《BMC infectious diseases》2007,7(1):37
Background
Cerebrospinal fluid (CSF) pleocytosis may be seen in asymptomatic HIV-infected individuals. This finding complicates interpretation of CSF abnormalities when such individuals are evaluated for other central nervous system infections. The goal of this study was to determine the relationship between CSF pleocytosis, central nervous system (CNS) antiretroviral penetration, adherence to antiretroviral medication regimens, neurological symptoms and performance on neuropsychological tests. 相似文献66.
67.
Robert C Susil Kevin Camphausen Peter Choyke Elliot R McVeigh Gary S Gustafson Holly Ning Robert W Miller Ergin Atalar C Norman Coleman Cynthia Ménard 《Magnetic resonance in medicine》2004,52(3):683-687
A technique for transperineal high-dose-rate (HDR) prostate brachytherapy and needle biopsy in a standard 1.5 T MRI scanner is demonstrated. In each of eight procedures (in four patients with intermediate to high risk localized prostate cancer), four MRI-guided transperineal prostate biopsies were obtained followed by placement of 14-15 hollow transperineal catheters for HDR brachytherapy. Mean needle-placement accuracy was 2.1 mm, 95% of needle-placement errors were less than 4.0 mm, and the maximum needle-placement error was 4.4 mm. In addition to guiding the placement of biopsy needles and brachytherapy catheters, MR images were also used for brachytherapy treatment planning and optimization. Because 1.5 T MR images are directly acquired during the interventional procedure, dependence on deformable registration is reduced and online image quality is maximized. 相似文献
68.
69.
Kevin Montgomery Michael Stephanides Stephen Schendel Muriel Ross 《Computerized medical imaging and graphics》2005,29(2-3):203-222
This paper covers work in virtual reality-based, patient-specific surgical planning over the past decade. It aims to comprehensively examine the user interface paradigms and system designs during that period of time and to objectively analyze their effectiveness for the task. The goal is to provide useful feedback on these interface and implementation paradigms to aid other researchers in this field. First, specialized systems for specific clinical use were produced with a limited set of visualization tools. Later, through collaboration with NASA, an immersive virtual environment was created to produce high-fidelity images for surgical simulation, but it underestimated the importance of collaboration. The next system, a networked, distributed virtual environment, provided immersion and collaboration, but the immersive paradigm was found to be of a disadvantage and the uniqueness of the framework unwieldy. A virtual model, workbench-style display was then created using a commercial package, but limitations of each were soon apparent. Finally, a specialized display, with an integrated visualization and simulation system is described and evaluated. Lessons learned include: surgical planning is an abstract process unlike surgical simulation; collaboration is important, as is stereo visualization; and that high-resolution preoperative images from standard viewpoints are desirable, but interaction is truly the key to planning. 相似文献
70.