全文获取类型
收费全文 | 45496篇 |
免费 | 3036篇 |
国内免费 | 117篇 |
专业分类
耳鼻咽喉 | 578篇 |
儿科学 | 1207篇 |
妇产科学 | 914篇 |
基础医学 | 5463篇 |
口腔科学 | 752篇 |
临床医学 | 4928篇 |
内科学 | 9765篇 |
皮肤病学 | 715篇 |
神经病学 | 3831篇 |
特种医学 | 1712篇 |
外国民族医学 | 3篇 |
外科学 | 7301篇 |
综合类 | 558篇 |
一般理论 | 47篇 |
预防医学 | 3978篇 |
眼科学 | 917篇 |
药学 | 3137篇 |
中国医学 | 36篇 |
肿瘤学 | 2807篇 |
出版年
2023年 | 276篇 |
2022年 | 522篇 |
2021年 | 1202篇 |
2020年 | 705篇 |
2019年 | 1097篇 |
2018年 | 1339篇 |
2017年 | 954篇 |
2016年 | 943篇 |
2015年 | 1133篇 |
2014年 | 1688篇 |
2013年 | 2267篇 |
2012年 | 3241篇 |
2011年 | 3340篇 |
2010年 | 1794篇 |
2009年 | 1645篇 |
2008年 | 2829篇 |
2007年 | 2755篇 |
2006年 | 2594篇 |
2005年 | 2647篇 |
2004年 | 2478篇 |
2003年 | 2235篇 |
2002年 | 2091篇 |
2001年 | 607篇 |
2000年 | 543篇 |
1999年 | 532篇 |
1998年 | 413篇 |
1997年 | 332篇 |
1996年 | 327篇 |
1995年 | 249篇 |
1994年 | 254篇 |
1993年 | 233篇 |
1992年 | 421篇 |
1991年 | 394篇 |
1990年 | 350篇 |
1989年 | 357篇 |
1988年 | 319篇 |
1987年 | 319篇 |
1986年 | 270篇 |
1985年 | 252篇 |
1984年 | 221篇 |
1983年 | 212篇 |
1982年 | 163篇 |
1981年 | 143篇 |
1980年 | 135篇 |
1979年 | 191篇 |
1978年 | 155篇 |
1977年 | 134篇 |
1975年 | 106篇 |
1974年 | 124篇 |
1973年 | 121篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
Daniel J. Snyder Thomas R. Kroshus Aakash Keswani Evan B. Garden Karl M. Koenig Kevin J. Bozic David S. Jevsevar Jashvant Poeran Calin S. Moucha 《The Journal of arthroplasty》2019,34(4):613-618
Background
Nursing Home Compare (NHC) ratings, created and maintained by Medicare, are used by both hospitals and consumers to aid in the skilled nursing facility (SNF) selection process. To date, no studies have linked NHC ratings to actual episode-based outcomes. The purpose of this study was to evaluate whether NHC ratings are valid predictors of 90-day complications, readmission, and bundle costs for patients discharged to an SNF after primary total joint arthroplasty (TJA).Methods
All SNF-discharged primary TJA cases in 2017 at a multihospital academic health system were queried. Demographic, psychosocial, and clinical variables were manually extracted from the health record. Medicare NHC ratings were then collected for each SNF. For patients in the Medicare bundle, postacute and total bundle cost was extracted from claims.Results
Four hundred eighty-eight patients were discharged to a total of 105 unique SNFs. In multivariate analysis, overall NHC rating was not predictive of 90-day readmission/major complications, >75th percentile postacute cost, or 90-day bundle cost exceeding the target price. SNF health inspection and quality measure ratings were also not predictive of 90-day readmission/major complications or bundle performance. A higher SNF staffing rating was independently associated with a decreased odds for >75th percentile 90-day postacute spend (odds ratio, 0.58; P = .01) and a 90-day bundle cost exceeding the target price (odds ratio = 0.69; P = .02) but was similarly not predictive of 90-day readmission/complications.Conclusion
Results of our study suggest that Medicare's NHC tool is not a useful predictor of 90-day costs, complications, or readmissions for SNFs within our health system. 相似文献3.
4.
The molecular and clinical impact of hepatocyte growth factor, its receptor, activators, and inhibitors in wound healing 总被引:1,自引:0,他引:1
Kevin Conway MRCS ; Patricia Price PhD ; Keith G. Harding FRCS ; Wen G. Jiang MD 《Wound repair and regeneration》2006,14(1):2-10
Wound healing involves a number of cellular and molecular events, many of which are controlled by soluble growth factors. In the process of healing, hepatocyte growth factor, a cytokine known to act as mitogen, motogen, and morphogen, has been postulated to play multiple roles during several stages of this complex biological process. Produced primarily by stromal fibroblasts, hepatocyte growth factor regulates angiogenesis, vascular permeability, cell migration, matrix deposition and degradation, and other biological processes. The current article discusses recent progress in understanding the multiple roles played by this growth factor in tissue repair. 相似文献
5.
Kevin L Taylor Rhonda K Oates Ron Grane Douglas W Leaman Ernest C Borden Daniel J Lindner 《Journal of interferon & cytokine research》2006,26(5):353-361
Interferon-alpha (IFN-alpha) has proved effective in the treatment of hemangiomas, hemangioblastomas, and Kaposi's sarcoma. To investigate the ability of IFNs to inhibit angiosarcoma, we used two transformed murine endothelial cell lines that form angiosarcomas in vivo. SVR and MS1-VEGF cell lines express oncogenic H-ras or vascular endothelial growth factor (VEGF), respectively. IFN-alpha1,8, which is active against murine and human cells, inhibited SVR and MS1-VEGF proliferation in vitro by 40% at 10(3) U/mL (p = 0.028). In vivo, IFN-alpha1,8 inhibited SVR tumor volume by 71% (p = 0.047) and MS1-VEGF volume by 79% (p = 0.003). Tumor-induced angiogenesis was decreased in SVR tumors by 52% (p = 0.005) and in MS1-VEGF tumors by 58% (p = 0.001). Sera from IFN-alpha1,8-treated mice bearing either SVR or MS1-VEGF tumors demonstrated a 5-fold increase in IP-10/CXCL10 (p = 0.001), an IFN-induced antiangiogenic protein. Both recombinant IP-10 and IFN-alpha1,8 inhibited human umbilical vein endothelial cell (HUVEC) vessel formation in the fibrin gel assay, a three-dimensional culture model of angiogenesis, by 56% at 25 ng/mL and 50% at 1.2 ng/mL, respectively (p < 0.001). An IP-10 blocking antibody restored vessel formation to 80% of untreated controls (p = 0.001). Given the magnitude of the in vivo response, these data suggested that the antitumor effects of IFN-alpha1,8 were likely mediated through angiogenesis inhibition rather than solely by direct inhibition of tumor cell proliferation. 相似文献
6.
7.
Meir Steiner Richard J. Katz Giulio Baldrighi Bernard J. Carroll 《Psychoneuroendocrinology》1981,6(1):81-90
(1) The estrous cycle in the rat may be used to study recurrent changes in motor behaviors and motivation which are strongly related to cyclic hormonal and CNS changes. (2) The peak in motivated behaviors occurs during a sharply defined period on the night between proestrus and estrus and is evident in facilitated wheel-running, lordosis, and intracranial self-stimulation. (3) Behaviors without a clearly motivated character do not show an estrous cyclicity. (4) The estrous cyclic variation in intracranial self-stimulation was observed at a specific locus — the pars campacta of the substantia nigra. (5) A neurochemical link between sexually motivated behavior, wheel running and intracranial self-stimulation is suggested. This link is in part dopaminergic but is probably also activated by many other systems. 相似文献
8.
R J Katz 《Neuroscience and biobehavioral reviews》1991,15(3):375-381
Intrusive thoughts and images, often of a violent, horrific, or blasphemous nature are the hallmark of Obsessive Compulsive Disorder (OCD). OCD patients frequently also often have reductions in normal serotonergic (5-HT) function. This paper proposes a model of 5-HT function involving the routine filtering and suppression of violent or libidinal impulses. This model accounts for OCD as an instance of failed inhibition. The model also appears to resemble Freud's model of ego-id interactions at least in part, suggesting that it may be possible to psychobiologically substantiate a Freudian metaphor. 相似文献
9.
10.