Chronic GVHD with nail involvement as predominant presentation

报告1例以甲损害为主要表现的慢性移植物抗宿主病.患者男,43岁.因指(趾)甲改变伴左足疼痛半年就诊.患者1年半前行姊供弟6/6相合异基因造血干细胞移植,血型A-A.半年前出现口腔白斑,视力下降及指(趾)甲改变.皮肤科检查:双侧颊黏膜可见环形白斑,口角溃疡.双手指甲可见纵向隆起及出血,双足趾甲变厚、表面粗糙、易断,部分远端缺失,左足大拇趾有触痛.     

H1-antihistamine use and head and neck cancer risk in type 2 diabetes mellitus

This study aimed to examine the association between the use of H1-antihistamines (AHs) and head and neck cancer (HNC) risk in patients with type 2 diabetes mellitus (T2DM). Data from the National Health Insurance Research Database of Taiwan were analyzed for the period from 2008 to 2018. A propensity-score-matched cohort of 54,384 patients each in the AH user and nonuser groups was created and analyzed using Kaplan-Meier method and Cox proportional hazards regression. The results showed that the risk of HNC was significantly lower in AH users (adjusted hazard ratio: 0.55, 95% CI: 0.48 to 0.64) and the incidence rate was also lower (5.16 vs. 8.10 per 100,000 person-years). The lower HNC incidence rate in AH users (95% CI: 0.63; 0.55 to 0.73) suggests that AH use may reduce the risk of HNC in T2DM patients.